FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989612982> ?p ?o ?g. }

• W2989612982 abstract "ERα, one of the classical receptors of estrogen, has been found to be abnormally up-regulated in patients with primary biliary cholangitis (PBC), which is an important factor leading to ductopenia. ERα-mediated signaling pathways are involved in proliferation of human intrahepatic biliary epithelial cells(HiBECs) and portal inflammation. Our previous studies have shown that the expression levels of ERα in the liver tissues of PBC patients are positively correlated with the levels of serum pro-inflammatory cytokines. The present study was designed to assess the relationship between abnormal ERα expression in small bile ducts and the progression of PBC. We examined the levels of multiple cytokines and analyzed their relationship with clinical parameters of livers functions in a cohort of 43 PBC patients and 45 healthy controls (HC). The levels of ERα expression and the relation with the levels of cytokines were further assessed. The localization of cytokines and ERα-mediated signaling pathways in liver were examined using immunohistochemistry. The possible underlying mechanisms of these alterations in PBC were explored in vitro. Our results demonstrated that the levels of IL-6, IL-8 and TNF-α were increased in PBC patients, and positively correlated with the serum AKP levels and ERα expression levels. Moreover, the expression of these cytokines were up-regulated in HiBECs that were stimulated with 17β-estradiol and PPT (an ERα agonist) and they also were positive in intrahepatic bile duct of PBC patients. The ERα-mediated expression of pro-inflammatory cytokines was induced by JNK, P38 and STAT3 phosphorylation in HiBECs. In addition, the CD54 expression was increased in HiBECs after ERα activation, which induced peripheral blood monouclear cells (PBMCs) recruitment. In conclusion, the present study highlighted a key role of abnormal ERα expression in inducing an inflammatory phenotype of HiBECs, which was critical in the development of inflammation and damage in small bile duct." @default.
• W2989612982 created "2019-12-05" @default.
• W2989612982 creator A5004755101 @default.
• W2989612982 creator A5007769713 @default.
• W2989612982 creator A5068883101 @default.
• W2989612982 creator A5076699095 @default.
• W2989612982 date "2019-12-05" @default.
• W2989612982 modified "2023-10-17" @default.
• W2989612982 title "Abnormal Expression of ERα in Cholangiocytes of Patients With Primary Biliary Cholangitis Mediated Intrahepatic Bile Duct Inflammation" @default.
• W2989612982 cites W1509635284 @default.
• W2989612982 cites W1601823889 @default.
• W2989612982 cites W1963778612 @default.
• W2989612982 cites W1964284255 @default.
• W2989612982 cites W1965332362 @default.
• W2989612982 cites W1969486048 @default.
• W2989612982 cites W1975425859 @default.
• W2989612982 cites W1979208563 @default.
• W2989612982 cites W1985445709 @default.
• W2989612982 cites W1989954597 @default.
• W2989612982 cites W1996080808 @default.
• W2989612982 cites W1996558377 @default.
• W2989612982 cites W2007868505 @default.
• W2989612982 cites W2011073567 @default.
• W2989612982 cites W2016929653 @default.
• W2989612982 cites W2018469741 @default.
• W2989612982 cites W2026750484 @default.
• W2989612982 cites W2030185339 @default.
• W2989612982 cites W2037746678 @default.
• W2989612982 cites W2045688706 @default.
• W2989612982 cites W2046796966 @default.
• W2989612982 cites W2065738196 @default.
• W2989612982 cites W2078763028 @default.
• W2989612982 cites W2083802827 @default.
• W2989612982 cites W2083811181 @default.
• W2989612982 cites W2088492313 @default.
• W2989612982 cites W2090442878 @default.
• W2989612982 cites W2091482013 @default.
• W2989612982 cites W2116977597 @default.
• W2989612982 cites W2118777938 @default.
• W2989612982 cites W2123884323 @default.
• W2989612982 cites W2124177504 @default.
• W2989612982 cites W2126220199 @default.
• W2989612982 cites W2131882991 @default.
• W2989612982 cites W2149495029 @default.
• W2989612982 cites W2163187036 @default.
• W2989612982 cites W2181964530 @default.
• W2989612982 cites W2196324096 @default.
• W2989612982 cites W2406168974 @default.
• W2989612982 cites W2463942975 @default.
• W2989612982 cites W2548154596 @default.
• W2989612982 cites W2549759233 @default.
• W2989612982 cites W2566224097 @default.
• W2989612982 cites W2576685898 @default.
• W2989612982 cites W2590579283 @default.
• W2989612982 cites W2602740512 @default.
• W2989612982 cites W2603558680 @default.
• W2989612982 cites W2605729742 @default.
• W2989612982 cites W2610202553 @default.
• W2989612982 cites W2744025711 @default.
• W2989612982 cites W2790991371 @default.
• W2989612982 cites W2794098640 @default.
• W2989612982 cites W2852463872 @default.
• W2989612982 cites W629976325 @default.
• W2989612982 doi "https://doi.org/10.3389/fimmu.2019.02815" @default.
• W2989612982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6907097" @default.
• W2989612982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31867004" @default.
• W2989612982 hasPublicationYear "2019" @default.
• W2989612982 type Work @default.
• W2989612982 sameAs 2989612982 @default.
• W2989612982 citedByCount "10" @default.
• W2989612982 countsByYear W29896129822020 @default.
• W2989612982 countsByYear W29896129822022 @default.
• W2989612982 countsByYear W29896129822023 @default.
• W2989612982 crossrefType "journal-article" @default.
• W2989612982 hasAuthorship W2989612982A5004755101 @default.
• W2989612982 hasAuthorship W2989612982A5007769713 @default.
• W2989612982 hasAuthorship W2989612982A5068883101 @default.
• W2989612982 hasAuthorship W2989612982A5076699095 @default.
• W2989612982 hasBestOaLocation W29896129821 @default.
• W2989612982 hasConcept C121608353 @default.
• W2989612982 hasConcept C126322002 @default.
• W2989612982 hasConcept C134018914 @default.
• W2989612982 hasConcept C164027704 @default.
• W2989612982 hasConcept C204232928 @default.
• W2989612982 hasConcept C2776914184 @default.
• W2989612982 hasConcept C2779777945 @default.
• W2989612982 hasConcept C2780186670 @default.
• W2989612982 hasConcept C2780788601 @default.
• W2989612982 hasConcept C530470458 @default.
• W2989612982 hasConcept C71924100 @default.
• W2989612982 hasConcept C84606932 @default.
• W2989612982 hasConceptScore W2989612982C121608353 @default.
• W2989612982 hasConceptScore W2989612982C126322002 @default.
• W2989612982 hasConceptScore W2989612982C134018914 @default.
• W2989612982 hasConceptScore W2989612982C164027704 @default.
• W2989612982 hasConceptScore W2989612982C204232928 @default.
• W2989612982 hasConceptScore W2989612982C2776914184 @default.
• W2989612982 hasConceptScore W2989612982C2779777945 @default.
• W2989612982 hasConceptScore W2989612982C2780186670 @default.
• W2989612982 hasConceptScore W2989612982C2780788601 @default.

• next