FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989614779> ?p ?o ?g. }

• W2989614779 endingPage "491" @default.
• W2989614779 startingPage "485" @default.
• W2989614779 abstract "Acute liver injury can be caused by oxidative stress within a short period and is a common pathway to many liver diseases. The liver is vulnerable to reactive oxygen species (ROS) and free radical-mediated disorders. β-arrestin2 was initially discovered to be a negative regulator of G protein-coupled receptor signaling. Recently, β-arrestin2 has been found to act as a multifunctional adaptor protein and play new roles in regulating intracellular signaling networks. However, the role of β-arrestin2 in the pathogenesis of acute liver injury is unclear. In this study, we hypothesize that β-arrestin2 regulates acute liver injury via modulation of oxidative stress. β-arrestin2 knockout mice were used to investigate the impacts of β-arrestin2 on carbon tetrachloride (CCl4)-induced acute liver injury and oxidative stress. Results here suggested that β-arrestin2 deficiency decreased serum activities of aminotransferase and alleviated liver injury induced by CCl4 injection as compared with wildtype mice. β-arrestin2 knockout mice exhibited stronger tolerance in oxidative stress compared with wild-type mice, which was demonstrated by decreased ROS level and increased superoxide dismutase (SOD) and glutathione (GSH) in the liver. Furthermore, β-arrestin2 deficiency significantly inhibited NOX4 (a major source of ROS) expression and the activation of the extracellular regulated kinase (ERK) and, c-Jun NH2-terminal kinase (JNK) pathways. These results suggest that β-arrestin2 deficiency protects against CCl4-induced acute liver injury through attenuating oxidative damage and decreased ERK and JNK phosphorylation." @default.
• W2989614779 created "2019-12-05" @default.
• W2989614779 creator A5003799076 @default.
• W2989614779 creator A5009933631 @default.
• W2989614779 creator A5015105154 @default.
• W2989614779 creator A5056337785 @default.
• W2989614779 creator A5066319171 @default.
• W2989614779 creator A5066429211 @default.
• W2989614779 date "2020-02-01" @default.
• W2989614779 modified "2023-10-05" @default.
• W2989614779 title "Depletion of β-arrestin 2 protects against CCl4-induced liver injury in mice" @default.
• W2989614779 cites W1973508839 @default.
• W2989614779 cites W2003398628 @default.
• W2989614779 cites W2007792203 @default.
• W2989614779 cites W2027328852 @default.
• W2989614779 cites W2031575950 @default.
• W2989614779 cites W2034435394 @default.
• W2989614779 cites W2070364726 @default.
• W2989614779 cites W2085128107 @default.
• W2989614779 cites W2097732812 @default.
• W2989614779 cites W2167151063 @default.
• W2989614779 cites W2218606859 @default.
• W2989614779 cites W2337397486 @default.
• W2989614779 cites W2340802999 @default.
• W2989614779 cites W2412668871 @default.
• W2989614779 cites W2594720372 @default.
• W2989614779 cites W2628967201 @default.
• W2989614779 cites W2790000387 @default.
• W2989614779 cites W2797560926 @default.
• W2989614779 cites W2802746217 @default.
• W2989614779 cites W2883704382 @default.
• W2989614779 cites W2890835610 @default.
• W2989614779 cites W2916260541 @default.
• W2989614779 cites W2917690878 @default.
• W2989614779 cites W2921855856 @default.
• W2989614779 cites W2922938977 @default.
• W2989614779 cites W2924157749 @default.
• W2989614779 cites W2926030672 @default.
• W2989614779 cites W2940346153 @default.
• W2989614779 cites W985842495 @default.
• W2989614779 doi "https://doi.org/10.1016/j.bbrc.2019.11.093" @default.
• W2989614779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31780259" @default.
• W2989614779 hasPublicationYear "2020" @default.
• W2989614779 type Work @default.
• W2989614779 sameAs 2989614779 @default.
• W2989614779 citedByCount "9" @default.
• W2989614779 countsByYear W29896147792020 @default.
• W2989614779 countsByYear W29896147792021 @default.
• W2989614779 countsByYear W29896147792022 @default.
• W2989614779 countsByYear W29896147792023 @default.
• W2989614779 crossrefType "journal-article" @default.
• W2989614779 hasAuthorship W2989614779A5003799076 @default.
• W2989614779 hasAuthorship W2989614779A5009933631 @default.
• W2989614779 hasAuthorship W2989614779A5015105154 @default.
• W2989614779 hasAuthorship W2989614779A5056337785 @default.
• W2989614779 hasAuthorship W2989614779A5066319171 @default.
• W2989614779 hasAuthorship W2989614779A5066429211 @default.
• W2989614779 hasConcept C126322002 @default.
• W2989614779 hasConcept C134018914 @default.
• W2989614779 hasConcept C170493617 @default.
• W2989614779 hasConcept C182704531 @default.
• W2989614779 hasConcept C183786373 @default.
• W2989614779 hasConcept C185592680 @default.
• W2989614779 hasConcept C2775838275 @default.
• W2989614779 hasConcept C2776151105 @default.
• W2989614779 hasConcept C2776637226 @default.
• W2989614779 hasConcept C2779719074 @default.
• W2989614779 hasConcept C2779765511 @default.
• W2989614779 hasConcept C48349386 @default.
• W2989614779 hasConcept C55493867 @default.
• W2989614779 hasConcept C57074206 @default.
• W2989614779 hasConcept C62478195 @default.
• W2989614779 hasConcept C71924100 @default.
• W2989614779 hasConcept C86803240 @default.
• W2989614779 hasConcept C95444343 @default.
• W2989614779 hasConceptScore W2989614779C126322002 @default.
• W2989614779 hasConceptScore W2989614779C134018914 @default.
• W2989614779 hasConceptScore W2989614779C170493617 @default.
• W2989614779 hasConceptScore W2989614779C182704531 @default.
• W2989614779 hasConceptScore W2989614779C183786373 @default.
• W2989614779 hasConceptScore W2989614779C185592680 @default.
• W2989614779 hasConceptScore W2989614779C2775838275 @default.
• W2989614779 hasConceptScore W2989614779C2776151105 @default.
• W2989614779 hasConceptScore W2989614779C2776637226 @default.
• W2989614779 hasConceptScore W2989614779C2779719074 @default.
• W2989614779 hasConceptScore W2989614779C2779765511 @default.
• W2989614779 hasConceptScore W2989614779C48349386 @default.
• W2989614779 hasConceptScore W2989614779C55493867 @default.
• W2989614779 hasConceptScore W2989614779C57074206 @default.
• W2989614779 hasConceptScore W2989614779C62478195 @default.
• W2989614779 hasConceptScore W2989614779C71924100 @default.
• W2989614779 hasConceptScore W2989614779C86803240 @default.
• W2989614779 hasConceptScore W2989614779C95444343 @default.
• W2989614779 hasFunder F4320321001 @default.
• W2989614779 hasIssue "2" @default.
• W2989614779 hasLocation W29896147791 @default.
• W2989614779 hasLocation W29896147792 @default.
• W2989614779 hasOpenAccess W2989614779 @default.

• next