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• W2989614835 abstract "Background: Veno-arterial extracorporeal life support (VA-ECLS) is widely used to treat refractory cardiogenic shock. However, increased left ventricular (LV) afterload in VA-ECLS can worsen pulmonary congestion and compromise myocardial recovery. Our objectives were to explore the efficacy, safety, and optimal timing of adjunctive LV venting strategies. Methods: A systematic search was performed on Medline, EMBASE, PubMed, CDSR, CCRCT, CINAHL, ClinicalTrials.Gov, and WHO ICTRP from inception until January 2019 for all relevant studies, including LV venting. Data were analyzed for mortality and weaning from VA-ECLS on the basis of timing of LV venting, along with adverse complications. Results: A total of 7995 patients were included from 62 observational studies, wherein 3458 patients had LV venting during VA-ECLS. LV venting significantly improved weaning from VA-ECLS (odds ratio, 0.62 [95% CI, 0.47–0.83]; P =0.001) and reduced short-term (30 day; risk ratio [RR], 0.86 [95% CI, 0.77–0.96]; P =0.008) but not in-hospital (RR, 0.92 [95% CI, 0.83–1.01] P =0.09) or long-term (6 months; RR, 0.96 [95% CI, 0.90–1.03]; P =0.27) mortality. Early (<12 hours; RR, 0.86 [95% CI, 0.75–0.99]; P =0.03) but not late (≥12 hours; RR, 0.99 [95% CI, 0.71–1.38]; P =0.93) LV venting significantly reduced short-term mortality. Patients with LV venting spent more time on VA-ECLS (3.6 versus 2.8 days, P <0.001), and mechanical ventilation (7.1 versus 4.6 days, P =0.013). With the exception of hemolysis (RR, 2.18 [95% CI, 1.58–3.01]; P <0.00001), overall adverse events did not differ. Conclusions: LV venting, especially if done early (<12 hours), appears to be associated with an increased success of weaning and reduced short-term mortality. Future studies are required to delineate the importance of any or early LV venting adjuncts on mortality and morbidity outcomes." @default.
• W2989614835 created "2019-12-05" @default.
• W2989614835 creator A5018500177 @default.
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• W2989614835 creator A5058530665 @default.
• W2989614835 creator A5077525366 @default.
• W2989614835 date "2019-11-01" @default.
• W2989614835 modified "2023-10-13" @default.
• W2989614835 title "Optimal Strategy and Timing of Left Ventricular Venting During Veno-Arterial Extracorporeal Life Support for Adults in Cardiogenic Shock" @default.
• W2989614835 cites W1488474786 @default.
• W2989614835 cites W1620735743 @default.
• W2989614835 cites W1943598972 @default.
• W2989614835 cites W1961921354 @default.
• W2989614835 cites W1964469401 @default.
• W2989614835 cites W1978087115 @default.
• W2989614835 cites W1990468576 @default.
• W2989614835 cites W1993395739 @default.
• W2989614835 cites W1993823264 @default.
• W2989614835 cites W1995122464 @default.
• W2989614835 cites W1998442273 @default.
• W2989614835 cites W2001862663 @default.
• W2989614835 cites W2016399675 @default.
• W2989614835 cites W2021747634 @default.
• W2989614835 cites W2022091748 @default.
• W2989614835 cites W2038455357 @default.
• W2989614835 cites W2053197230 @default.
• W2989614835 cites W2057772670 @default.
• W2989614835 cites W2058171514 @default.
• W2989614835 cites W2069922575 @default.
• W2989614835 cites W2070587237 @default.
• W2989614835 cites W2072332037 @default.
• W2989614835 cites W2075242454 @default.
• W2989614835 cites W2084525533 @default.
• W2989614835 cites W2085326310 @default.
• W2989614835 cites W2085452873 @default.
• W2989614835 cites W2091917447 @default.
• W2989614835 cites W2094451022 @default.
• W2989614835 cites W2095284560 @default.
• W2989614835 cites W2100061718 @default.
• W2989614835 cites W2103144114 @default.
• W2989614835 cites W2106703370 @default.
• W2989614835 cites W2107328434 @default.
• W2989614835 cites W2110253130 @default.
• W2989614835 cites W2126930838 @default.
• W2989614835 cites W2131652439 @default.
• W2989614835 cites W2136353975 @default.
• W2989614835 cites W2144243848 @default.
• W2989614835 cites W2147088947 @default.
• W2989614835 cites W2149463609 @default.
• W2989614835 cites W2152180648 @default.
• W2989614835 cites W2156098321 @default.
• W2989614835 cites W2159789887 @default.
• W2989614835 cites W2162396475 @default.
• W2989614835 cites W2170179774 @default.
• W2989614835 cites W2170721979 @default.
• W2989614835 cites W2190459986 @default.
• W2989614835 cites W2216526141 @default.
• W2989614835 cites W2223601492 @default.
• W2989614835 cites W2315782269 @default.
• W2989614835 cites W2316831621 @default.
• W2989614835 cites W2437410810 @default.
• W2989614835 cites W2484134905 @default.
• W2989614835 cites W2495298941 @default.
• W2989614835 cites W2531249220 @default.
• W2989614835 cites W2531269403 @default.
• W2989614835 cites W2531281781 @default.
• W2989614835 cites W2560018873 @default.
• W2989614835 cites W2563391002 @default.
• W2989614835 cites W2601373345 @default.
• W2989614835 cites W2601918078 @default.
• W2989614835 cites W2606397823 @default.
• W2989614835 cites W2611509057 @default.
• W2989614835 cites W2612524408 @default.
• W2989614835 cites W2613766232 @default.
• W2989614835 cites W2621054826 @default.
• W2989614835 cites W2622466800 @default.
• W2989614835 cites W2728706893 @default.
• W2989614835 cites W2758952081 @default.
• W2989614835 cites W2759668837 @default.
• W2989614835 cites W2761300305 @default.
• W2989614835 cites W2775222057 @default.
• W2989614835 cites W2782120765 @default.
• W2989614835 cites W2789904780 @default.
• W2989614835 cites W2792963059 @default.
• W2989614835 cites W2795587864 @default.
• W2989614835 cites W2795961096 @default.
• W2989614835 cites W2796431106 @default.
• W2989614835 cites W2800968815 @default.
• W2989614835 cites W2801839997 @default.
• W2989614835 cites W2804995292 @default.
• W2989614835 cites W2884578009 @default.
• W2989614835 cites W2884633691 @default.
• W2989614835 cites W2887179887 @default.
• W2989614835 cites W2890985276 @default.
• W2989614835 cites W2892767518 @default.
• W2989614835 cites W2897556235 @default.

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