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• W2989618284 abstract "Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of esophageal cancer. miRNA (miR)-542-3p is a tumor suppressor in multiple types of cancer. However, whether and how miR-542-3p contributes to the progression of esophageal cancer remains unknown, and this is the aim of the present study. In the current study, decreased expression of miR-542-3p was detected in tumor tissues compared with normal tissues from patients with esophageal cancer, and miR-542-3p expression was negatively correlated with mRNA expression levels of ovarian tumor domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) in tumor tissues from patients with esophageal cancer. In KYSE150 human esophageal squamous cell carcinoma cells, overexpression of miR-542-3p significantly decreased OTUB1 at mRNA and protein levels, whereas downregulation of miR-542-3p significantly increased OTUB1 expression. Using a dual-luciferase assay, OTUB1 was validated to be a target gene of miR-542-3p in KYSE150 cells. Functionally, miR-542-3p significantly inhibited the migration and invasion of KYSE150 cells by repression of OTUB1 expression. These results demonstrated that miR-542-3p may promote the metastasis of esophageal cancer cells, and indicated that miR-542-3p may be a treatment target for esophageal cancer." @default.
• W2989618284 created "2019-12-05" @default.
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• W2989618284 date "2019-11-20" @default.
• W2989618284 modified "2023-09-29" @default.
• W2989618284 title "MicroRNA‑542‑3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells" @default.
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• W2989618284 doi "https://doi.org/10.3892/mmr.2019.10836" @default.
• W2989618284 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6896300" @default.
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