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- W2989619493 endingPage "170225" @default.
- W2989619493 startingPage "170225" @default.
- W2989619493 abstract "• Unimolecular peptide agonists activating multiple endogenous hormone receptors are advancing as treatments for obesity and type 2 diabetes. • Of particular interest are the receptors of GLP-1, GIP, and glucagon. • This approach provides complimentary but distinct mechanisms to enhance body weight lowering and glycemic control in animals. • Many questions remain about the long-term efficacy and safety of such multimode agonists, and clinical data have only begun to report. The continued global growth in the prevalence of obesity coupled with the limited number of efficacious and safe treatment options elevates the importance of innovative pharmaceutical approaches. Combinatorial strategies that harness the metabolic benefits of multiple hormonal mechanisms have emerged at the preclinical and more recently clinical stages of drug development. A priority has been anti-obesity unimolecular peptides that function as balanced, high potency poly-agonists at two or all the cellular receptors for the endocrine hormones glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon. This report reviews recent progress in this area, with emphasis on what the initial clinical results demonstrate and what remains to be addressed." @default.
- W2989619493 created "2019-12-05" @default.
- W2989619493 creator A5000358288 @default.
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- W2989619493 creator A5040729053 @default.
- W2989619493 creator A5050283762 @default.
- W2989619493 creator A5071517746 @default.
- W2989619493 date "2020-03-01" @default.
- W2989619493 modified "2023-10-13" @default.
- W2989619493 title "Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates" @default.
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