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- W2989622648 abstract "Introduction Poor sleep1 as well as white matter hyperintensities (WMH), which are macroscale markers of cerebrovascular health indicating white matter lesion,2 have been shown to increase the risk of dementia. However, the relationship between these two putative risk factors of dementia is unclear. Method Here we use data from the UK Biobank (N=5505, aged from 45 to 73) to elucidate the effect of poor sleep (insomnia, snoring, daytime sleepiness and short sleep duration) on WMH load. The sleep variables were obtained using a digital questionnaire, whereas the WMH load was derived from automated segmentation of T2 FLAIR magnetic resonance images using the BIANCA tool in FSL. Results We show that age, snoring and daytime sleepiness significantly predict a higher WMH load (linear model, adjusted R²=0.13, p Finally, a sleep burden score summing poor sleep markers significantly predicted the WMH load, when controlling for cardiovascular factors (table 1). Removing the sleep burden score leads to a significant decrease in the power of the model (ANOVA, p=0.027). Discussion This exploratory analysis confirms the impact of measures of poor sleep on cerebrovascular health, proposing a complex relationship between sleep and WMH loads involving cardiovascular features 3 4 in a large ageing population. Further work will examine the wider implications of measures of poor sleep on cognition and brain function. References Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ 2010;341:c3666. Ju YS, Lucey BP, Holtzman DM. Sleepand Alzheimer disease pathology—a bidirectional relationship. Nature reviews Neurology 2014;10(2):115. Kocevska D, Cremers LG, Lysen TS, Luik AI, Ikram MA, Vernooij MW, et al. Sleep complaints and cerebral white matter: A prospective bidirectional study. J Psychiatr Res 2019;112:77–82. Lu S, Song L, Wang D, Zhang X, Lv X, Yin H, et al. White matter hyperintensity and cognitive impairments in chronic insomniacs. Neuroreport 2019;30(9):612–618." @default.
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- W2989622648 date "2019-11-01" @default.
- W2989622648 modified "2023-09-24" @default.
- W2989622648 title "P038 Investigating the impact of poor sleep on cardiovascular health and cerebrovascular burden in healthy ageing using the UK biobank data" @default.
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- W2989622648 doi "https://doi.org/10.1136/bmjresp-2019-bssconf.38" @default.
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