Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989644414> ?p ?o ?g. }
- W2989644414 endingPage "788" @default.
- W2989644414 startingPage "776" @default.
- W2989644414 abstract "Induction of nuclear factor of activated T cell cytoplasmic 1 (NFATc1) by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) is essential for macrophage differentiation into osteoclasts (OCs), but the underlying mechanisms remain unclear. The ability of poly(ADP-ribose) polymerase 1 (PARP1) to poly-ADP-ribosylate NFATc1 in T cells prompted us to investigate the PARP1 and NFATc1 interaction during osteoclastogenesis. However, extensive studies failed to directly link PARP1 to NFATc1. A combination of transcriptomics and proteomics studies was then used to identify PARP1 targets under these conditions. These unbiased approaches in conjunction with site-directed mutagenesis studies revealed that PARP1 inhibited NFATc1 expression and OC formation by ADP-ribosylating histone H2B at serine 7 and decreasing the occupancy of this histone variant at the NFATc1 promoter. The anti-osteoclastogenic function of PARP1 was confirmed in vivo in several mouse models of PARP1 loss-of-function or gain-of-function, including a novel model in which PARP1 was conditionally ablated in myeloid cells. Thus, PARP1 ADP-ribosylates H2B to negatively regulate NFATc1 expression and OC differentiation. © 2019 American Society for Bone and Mineral Research." @default.
- W2989644414 created "2019-12-05" @default.
- W2989644414 creator A5030968272 @default.
- W2989644414 creator A5035162172 @default.
- W2989644414 creator A5039176168 @default.
- W2989644414 creator A5040295712 @default.
- W2989644414 creator A5058902204 @default.
- W2989644414 creator A5065820017 @default.
- W2989644414 creator A5066068730 @default.
- W2989644414 creator A5069280887 @default.
- W2989644414 creator A5077454404 @default.
- W2989644414 creator A5082059234 @default.
- W2989644414 creator A5086210412 @default.
- W2989644414 date "2020-01-07" @default.
- W2989644414 modified "2023-10-15" @default.
- W2989644414 title "PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation" @default.
- W2989644414 cites W1511356620 @default.
- W2989644414 cites W1595293335 @default.
- W2989644414 cites W1728740210 @default.
- W2989644414 cites W1974916823 @default.
- W2989644414 cites W1975568696 @default.
- W2989644414 cites W1977387411 @default.
- W2989644414 cites W1978727518 @default.
- W2989644414 cites W1989944094 @default.
- W2989644414 cites W1992633066 @default.
- W2989644414 cites W2001055161 @default.
- W2989644414 cites W2006072231 @default.
- W2989644414 cites W2012790791 @default.
- W2989644414 cites W2018969644 @default.
- W2989644414 cites W2025162592 @default.
- W2989644414 cites W2031603575 @default.
- W2989644414 cites W2032276295 @default.
- W2989644414 cites W2035638429 @default.
- W2989644414 cites W2040971700 @default.
- W2989644414 cites W2043171666 @default.
- W2989644414 cites W2045450732 @default.
- W2989644414 cites W2045891124 @default.
- W2989644414 cites W2050547572 @default.
- W2989644414 cites W2054540776 @default.
- W2989644414 cites W2058058143 @default.
- W2989644414 cites W2062256108 @default.
- W2989644414 cites W2064501897 @default.
- W2989644414 cites W2066490621 @default.
- W2989644414 cites W2066749771 @default.
- W2989644414 cites W2071006764 @default.
- W2989644414 cites W2072384106 @default.
- W2989644414 cites W2072820883 @default.
- W2989644414 cites W2077897662 @default.
- W2989644414 cites W2083984635 @default.
- W2989644414 cites W2089709834 @default.
- W2989644414 cites W2090850273 @default.
- W2989644414 cites W2091273641 @default.
- W2989644414 cites W2092610623 @default.
- W2989644414 cites W2096425957 @default.
- W2989644414 cites W2097065948 @default.
- W2989644414 cites W2102435095 @default.
- W2989644414 cites W2109690762 @default.
- W2989644414 cites W2115736737 @default.
- W2989644414 cites W2118542406 @default.
- W2989644414 cites W2118888526 @default.
- W2989644414 cites W2123115454 @default.
- W2989644414 cites W2124985265 @default.
- W2989644414 cites W2126202075 @default.
- W2989644414 cites W2126238352 @default.
- W2989644414 cites W2135364719 @default.
- W2989644414 cites W2138576901 @default.
- W2989644414 cites W2140729960 @default.
- W2989644414 cites W2149250793 @default.
- W2989644414 cites W2154132663 @default.
- W2989644414 cites W2155255930 @default.
- W2989644414 cites W2160073632 @default.
- W2989644414 cites W2164708087 @default.
- W2989644414 cites W2166820820 @default.
- W2989644414 cites W2170551349 @default.
- W2989644414 cites W2176134716 @default.
- W2989644414 cites W2267978512 @default.
- W2989644414 cites W2287358372 @default.
- W2989644414 cites W2310308499 @default.
- W2989644414 cites W2413398355 @default.
- W2989644414 cites W2506892818 @default.
- W2989644414 cites W2509023402 @default.
- W2989644414 cites W2525134285 @default.
- W2989644414 cites W2567339323 @default.
- W2989644414 cites W2577827693 @default.
- W2989644414 cites W2587003776 @default.
- W2989644414 cites W2607296939 @default.
- W2989644414 cites W2729540055 @default.
- W2989644414 cites W2736034593 @default.
- W2989644414 cites W2748964630 @default.
- W2989644414 cites W2772487490 @default.
- W2989644414 cites W2886277684 @default.
- W2989644414 cites W2888547849 @default.
- W2989644414 cites W2893419667 @default.
- W2989644414 cites W2895790999 @default.
- W2989644414 cites W2900109797 @default.
- W2989644414 cites W2914567327 @default.
- W2989644414 cites W2923685508 @default.
- W2989644414 cites W2936121316 @default.