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• W2989644808 endingPage "105351" @default.
• W2989644808 startingPage "105351" @default.
• W2989644808 abstract "Frequent heavy-metal pollution accidents severely deteriorated the source water quality of drinking water treatment plants (DWTP). Limited data have explicitly addressed the impact of these incidents on bacterial antibiotic resistance (BAR). In present study, we investigated the shift of antibiotic resistome caused by heavy metal pollution incidents via simulating an arsenic shock loading [As (III)], along with the associated risks imposed on drinking water systems. The results indicated that a quick co-selection of antibiotic resistant bacteria (ARB) was achieved after exposure to 0.2–1 mg/L As (III) for only 6 h, meanwhile, there was an increase of relative abundance of antibiotic resistance genes (ARGs) and mobile genetic elements. Most of the co-selected BAR could be maintained for at least 4 days in the absence of As (III) and antibiotics, implying that the pollution in source water possibly contributed to the preservation and proliferation of antibiotic resistance determinants in the subsequent DWTP. Bacterial community structure analysis showed a strong correlation between bacterial community shift and BAR promotion, and enrichment of opportunistic bacteria (e.g. Escherichia-Shigella, Empedobacter sp. and Elizabethkingia sp.). The results indicated a potential epidemiological threat to the public due to accident-level arsenic contamination in the source water. This study gave insight into understanding the source water pollution accidents from the perspective of bio-hazard and biological risks, and highlighted a neglected important source of BAR in drinking water systems." @default.
• W2989644808 created "2019-12-05" @default.
• W2989644808 creator A5008094293 @default.
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• W2989644808 creator A5085009139 @default.
• W2989644808 date "2020-02-01" @default.
• W2989644808 modified "2023-10-18" @default.
• W2989644808 title "Co-selection and stability of bacterial antibiotic resistance by arsenic pollution accidents in source water" @default.
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• W2989644808 doi "https://doi.org/10.1016/j.envint.2019.105351" @default.
• W2989644808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31794937" @default.
• W2989644808 hasPublicationYear "2020" @default.
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