Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989663699> ?p ?o ?g. }
- W2989663699 endingPage "6698" @default.
- W2989663699 startingPage "6691" @default.
- W2989663699 abstract "Long non-coding RNA MEG3 has been reported to implicate in the progression of several cancers. Nevertheless, few studies have focused on the role of MEG3 in the development of diabetic nephropathy. Here, we demonstrated MEG3 was differently expressed by > 4 fold and was elevated significantly using lncRNA microarray in DN patient serum. Besides, MEG3 knockdown alleviated proliferation, fibrosis and induced apoptosis of mesangial cells under high glucose condition. Furthermore, bioinformatics predictions showed that MEG3 is a direct target of miR-145. In the vivo experiment, we found MEG3 silencing decreased the laboratory indicators and fibrosis-related protein secretion in db/db mice. Altogether, our study suggests MEG3 may play as an important role in progression of diabetic nephropathy, contributing to a novel understanding of pathogenesis and underlying therapeutic strategies for diabetic nephropathy." @default.
- W2989663699 created "2019-12-05" @default.
- W2989663699 creator A5011376002 @default.
- W2989663699 creator A5022611537 @default.
- W2989663699 creator A5066888888 @default.
- W2989663699 creator A5082789515 @default.
- W2989663699 date "2019-01-01" @default.
- W2989663699 modified "2023-10-16" @default.
- W2989663699 title "Long non-coding RNA MEG3 impacts diabetic nephropathy progression through sponging miR-145." @default.
- W2989663699 cites W1595278394 @default.
- W2989663699 cites W1848076673 @default.
- W2989663699 cites W2005032654 @default.
- W2989663699 cites W2007032397 @default.
- W2989663699 cites W2010691380 @default.
- W2989663699 cites W2022888172 @default.
- W2989663699 cites W2036090583 @default.
- W2989663699 cites W2037691883 @default.
- W2989663699 cites W2046387002 @default.
- W2989663699 cites W2050114212 @default.
- W2989663699 cites W2075543245 @default.
- W2989663699 cites W2085574022 @default.
- W2989663699 cites W2094889529 @default.
- W2989663699 cites W2099176640 @default.
- W2989663699 cites W2124502714 @default.
- W2989663699 cites W2127883421 @default.
- W2989663699 cites W2147535627 @default.
- W2989663699 cites W2276848727 @default.
- W2989663699 cites W2321723146 @default.
- W2989663699 cites W2432593729 @default.
- W2989663699 cites W2509738156 @default.
- W2989663699 cites W2535995771 @default.
- W2989663699 cites W2635777747 @default.
- W2989663699 cites W2766004179 @default.
- W2989663699 cites W2803579532 @default.
- W2989663699 cites W2883396233 @default.
- W2989663699 cites W2895782727 @default.
- W2989663699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6834487" @default.
- W2989663699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31737219" @default.
- W2989663699 hasPublicationYear "2019" @default.
- W2989663699 type Work @default.
- W2989663699 sameAs 2989663699 @default.
- W2989663699 citedByCount "9" @default.
- W2989663699 countsByYear W29896636992021 @default.
- W2989663699 countsByYear W29896636992022 @default.
- W2989663699 countsByYear W29896636992023 @default.
- W2989663699 crossrefType "journal-article" @default.
- W2989663699 hasAuthorship W2989663699A5011376002 @default.
- W2989663699 hasAuthorship W2989663699A5022611537 @default.
- W2989663699 hasAuthorship W2989663699A5066888888 @default.
- W2989663699 hasAuthorship W2989663699A5082789515 @default.
- W2989663699 hasConcept C104317684 @default.
- W2989663699 hasConcept C119056186 @default.
- W2989663699 hasConcept C126322002 @default.
- W2989663699 hasConcept C134018914 @default.
- W2989663699 hasConcept C150194340 @default.
- W2989663699 hasConcept C173396325 @default.
- W2989663699 hasConcept C186836561 @default.
- W2989663699 hasConcept C190283241 @default.
- W2989663699 hasConcept C207001950 @default.
- W2989663699 hasConcept C2779922275 @default.
- W2989663699 hasConcept C2780559512 @default.
- W2989663699 hasConcept C2781184683 @default.
- W2989663699 hasConcept C2781369401 @default.
- W2989663699 hasConcept C502942594 @default.
- W2989663699 hasConcept C54355233 @default.
- W2989663699 hasConcept C555293320 @default.
- W2989663699 hasConcept C62203573 @default.
- W2989663699 hasConcept C67705224 @default.
- W2989663699 hasConcept C71924100 @default.
- W2989663699 hasConcept C86803240 @default.
- W2989663699 hasConceptScore W2989663699C104317684 @default.
- W2989663699 hasConceptScore W2989663699C119056186 @default.
- W2989663699 hasConceptScore W2989663699C126322002 @default.
- W2989663699 hasConceptScore W2989663699C134018914 @default.
- W2989663699 hasConceptScore W2989663699C150194340 @default.
- W2989663699 hasConceptScore W2989663699C173396325 @default.
- W2989663699 hasConceptScore W2989663699C186836561 @default.
- W2989663699 hasConceptScore W2989663699C190283241 @default.
- W2989663699 hasConceptScore W2989663699C207001950 @default.
- W2989663699 hasConceptScore W2989663699C2779922275 @default.
- W2989663699 hasConceptScore W2989663699C2780559512 @default.
- W2989663699 hasConceptScore W2989663699C2781184683 @default.
- W2989663699 hasConceptScore W2989663699C2781369401 @default.
- W2989663699 hasConceptScore W2989663699C502942594 @default.
- W2989663699 hasConceptScore W2989663699C54355233 @default.
- W2989663699 hasConceptScore W2989663699C555293320 @default.
- W2989663699 hasConceptScore W2989663699C62203573 @default.
- W2989663699 hasConceptScore W2989663699C67705224 @default.
- W2989663699 hasConceptScore W2989663699C71924100 @default.
- W2989663699 hasConceptScore W2989663699C86803240 @default.
- W2989663699 hasIssue "10" @default.
- W2989663699 hasLocation W29896636991 @default.
- W2989663699 hasOpenAccess W2989663699 @default.
- W2989663699 hasPrimaryLocation W29896636991 @default.
- W2989663699 hasRelatedWork W1563850031 @default.
- W2989663699 hasRelatedWork W2038405492 @default.
- W2989663699 hasRelatedWork W2038657938 @default.
- W2989663699 hasRelatedWork W2753482964 @default.