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- W2989666530 abstract "Anaphylaxis is commonly encountered in the allergy clinic, especially in practices with a large number of patients receiving immunotherapy. Risk factors that may increase the frequency or severity of anaphylaxis are still being investigated. To our knowledge, a study has not been conducted that evaluated the association between antihypertensive therapy and the severity of anaphylaxis or whether the number of antihypertensives is associated with the severity of anaphylaxis. This study sought to investigate these associations and bridge the gap in the available medical literature on this topic. β-Blockers have already been reported to be associated with anaphylaxis refractory to treatment, and angiotensin-converting enzyme inhibitors (ACEIs) are associated with higher-grade reactions in some studies. 1 Cox L. Nelson H. Lockey R. et al. Allergen immunotherapy: a practice parameter third update. J Allergy Clin Immunol. 2011; 127: S1-S55 Abstract Full Text Full Text PDF PubMed Scopus (819) Google Scholar , 2 Rueff F. Przybilla B. Bilo M.B. et al. Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase. J Allergy Clin Immunol. 2009; 124: 1047-1054 Abstract Full Text Full Text PDF PubMed Scopus (333) Google Scholar , 3 Carlson G. Wong P. White K. Quinn J. Evaluation of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker therapy in immunotherapy associated systemic reactions. J Allergy Clin Immunol Pract. 2017; 5: 1430-1432 Abstract Full Text Full Text PDF PubMed Scopus (4) Google Scholar Several reasons for these higher-grade reactions and refractory anaphylaxis include a dampening of the compensatory mechanisms for anaphylaxis and a decreased effectiveness of the treatment. For example, β-blockers cause decreased heart rate and decreased vascular resistance, which lower blood pressure. β-Blockers also partially inhibit response to treatment with epinephrine, which acts on α- and β-adrenergic receptors. In addition, simply taking these types of medications is a surrogate marker for comorbid illness, which may be putting patients at increased risk." @default.
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- W2989666530 date "2020-02-01" @default.
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- W2989666530 title "Evaluation of antihypertensive therapies in immunotherapy-associated systemic reactions" @default.
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- W2989666530 doi "https://doi.org/10.1016/j.anai.2019.11.017" @default.
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