FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989679597> ?p ?o ?g. }

• W2989679597 abstract "Obesity, mild hypertension and endothelial function are all predictors of cardiovascular disease in women, and we propose that these factors are interrelated. We hypothesized that obesity and high blood pressure are associated with endothelial dysfunction in young women. Further, we hypothesized that short-term low-dose ethinyl estradiol treatment would mitigate this dysfunction. We examined hyperemic responses before and during 30 μg/day oral ethinyl estradiol (EE) treatment for 7 days in 16 healthy women (mean 26 ± 5, 19–35 yrs) with normal (NBP; n=7, MAP range: 78–91 mmHg) or mildly elevated blood pressure (HBP; n=9, MAP range: 95–113 mmHg). We evaluated brachial vasodilatory responses following two stimuli designed to elicit different levels of shear stress: 5-min occlusion (RH-FMD), and 3-min occlusion with ischemic handgrip exercise (IE-FMD). Body composition did not impact RH-FMD or IE-FMD responses. In contrast, Pre-EE, HBP had lower IE-FMD responses relative to NBP (8.0 ± 3.5% vs. 12.3 ± 3.2%, respectively; P=0.05). During EE, IE-FMD increased in HBP (12.8 ± 6.1%; P=0.02) and decreased in NBP (5.6 ± 2.4%, P<0.01). The increase in shear stress (8659 ± 4964 vs. 14753 ± 8189 AUC, s−1; P=0.04) contributed to the increase in IE-FMD in HBP subjects during EE, while shear stress did not change with EE in NBP (9740 ± 3222 vs. 10564 ± 2984 AUC, s−1; P=0.76). MAP did not predict RH-FMD responses or associated shear stress, pre-or during-EE. Thus, 1) in young healthy women, moderately elevated blood pressure was a predictor of endothelial function whereas obesity was not; 2) EE mitigated endothelial dysfunction associated with elevated blood pressure; 3) the enhanced shear stress stimulus was able to subtle differences in endothelial function where the standard FMD stimulus did not. Because HBP women had only mildly high blood pressure, these data are of particular significance given the new American Heart Association guidelines for hypertension. Support or Funding Information Supported by the APS Undergraduate Research Excellence Fellowship; the Paul Titus Fellowship Fund, Dept. Obstetrics Gynecology and Reproductive Sciences, Yale School of Medicine; and the AHA Postdoctoral Fellowship. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal." @default.
• W2989679597 created "2019-12-05" @default.
• W2989679597 creator A5010871611 @default.
• W2989679597 creator A5025562404 @default.
• W2989679597 creator A5084549224 @default.
• W2989679597 creator A5084882104 @default.
• W2989679597 date "2018-04-01" @default.
• W2989679597 modified "2023-09-27" @default.
• W2989679597 title "Blood Pressure Predicts Endothelial Function and Effect of Ethinyl Estradiol in Young Obese and Lean Women" @default.
• W2989679597 doi "https://doi.org/10.1096/fasebj.2018.32.1_supplement.713.3" @default.
• W2989679597 hasPublicationYear "2018" @default.
• W2989679597 type Work @default.
• W2989679597 sameAs 2989679597 @default.
• W2989679597 citedByCount "0" @default.
• W2989679597 crossrefType "journal-article" @default.
• W2989679597 hasAuthorship W2989679597A5010871611 @default.
• W2989679597 hasAuthorship W2989679597A5025562404 @default.
• W2989679597 hasAuthorship W2989679597A5084549224 @default.
• W2989679597 hasAuthorship W2989679597A5084882104 @default.
• W2989679597 hasConcept C120770815 @default.
• W2989679597 hasConcept C126322002 @default.
• W2989679597 hasConcept C134018914 @default.
• W2989679597 hasConcept C164705383 @default.
• W2989679597 hasConcept C2776992346 @default.
• W2989679597 hasConcept C2777604165 @default.
• W2989679597 hasConcept C2780972559 @default.
• W2989679597 hasConcept C511355011 @default.
• W2989679597 hasConcept C71924100 @default.
• W2989679597 hasConcept C84393581 @default.
• W2989679597 hasConceptScore W2989679597C120770815 @default.
• W2989679597 hasConceptScore W2989679597C126322002 @default.
• W2989679597 hasConceptScore W2989679597C134018914 @default.
• W2989679597 hasConceptScore W2989679597C164705383 @default.
• W2989679597 hasConceptScore W2989679597C2776992346 @default.
• W2989679597 hasConceptScore W2989679597C2777604165 @default.
• W2989679597 hasConceptScore W2989679597C2780972559 @default.
• W2989679597 hasConceptScore W2989679597C511355011 @default.
• W2989679597 hasConceptScore W2989679597C71924100 @default.
• W2989679597 hasConceptScore W2989679597C84393581 @default.
• W2989679597 hasFunder F4320332501 @default.
• W2989679597 hasIssue "S1" @default.
• W2989679597 hasLocation W29896795971 @default.
• W2989679597 hasOpenAccess W2989679597 @default.
• W2989679597 hasPrimaryLocation W29896795971 @default.
• W2989679597 hasRelatedWork W1546522262 @default.
• W2989679597 hasRelatedWork W1857487118 @default.
• W2989679597 hasRelatedWork W1983790951 @default.
• W2989679597 hasRelatedWork W2023025903 @default.
• W2989679597 hasRelatedWork W2124111134 @default.
• W2989679597 hasRelatedWork W2141608973 @default.
• W2989679597 hasRelatedWork W2354270518 @default.
• W2989679597 hasRelatedWork W2358133512 @default.
• W2989679597 hasRelatedWork W2769567662 @default.
• W2989679597 hasRelatedWork W1508352909 @default.
• W2989679597 hasVolume "32" @default.
• W2989679597 isParatext "false" @default.
• W2989679597 isRetracted "false" @default.
• W2989679597 magId "2989679597" @default.
• W2989679597 workType "article" @default.