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- W2989686983 abstract "Autoimmune diseases are multiple complex disorders, which characterized by the immune responses against self-antigens and affect about 5% of the population worldwide [ 1 Aringer M. Systemic autoimmune diseases-fit for 2020!. Z Rheumatol. 2019; 78: 499 Crossref PubMed Scopus (1) Google Scholar , 2 Garcia-Carrasco M. Mendoza-Pinto C. Functional gastrointestinal disorders in women with systemic lupus erythematosus aA case-control study. 2019e13693 Google Scholar , 3 Gershwin L.J. Current and newly emerging autoimmune diseases. Neurogastroenterol Motility. 2018; 48: 323-338 Google Scholar , 4 Ortona E. Pierdominici M. Maselli A. et al. Sex-based differences in autoimmune diseases. Ann. Ist. Super. Sanita. 2016; 52: 205-212 PubMed Google Scholar ]. Rheumatoid arthritis (RA), a major of autoimmune diseases, affects joints and leads to chronic inflammation in synovium. RA susceptibility depends on a complex interaction between environment and genetic factors. The signal transducer and activator of transcription 4 (STAT4) genetic variant has been reported to be associated with RA in several ethnic populations [ [5] Iuliano A. Galeazzi M. Sebastiani G.D. Antiphospholipid syndrome's genetic and epigenetic aspects. Autoimmun Rev. 2019; 102352 Crossref PubMed Scopus (16) Google Scholar ]. This study aims to assess the distribution of STAT4 rs7574865 polymorphism to RA susceptibility according to the ethnicity, ages of cases. Additionally, it was also conduct to check for the association between STAT4 rs7574865 with RA under a status of a positive or negative anti-CCP and RF." @default.
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- W2989686983 date "2020-01-01" @default.
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- W2989686983 title "Association between rs7574865 polymorphism in STAT4 gene and rheumatoid arthritis: An updated meta-analysis" @default.
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- W2989686983 doi "https://doi.org/10.1016/j.ejim.2019.11.009" @default.
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