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• W2989696708 abstract "The spatial mapping of localized events in brain activity critically depends on the correct identification of the pattern signatures associated with those events. For instance, in the context of epilepsy research, a number of different electrophysiological patterns have been associated with epileptogenic activity. Motivated by the need to define automated seizure focus detectors, we propose a novel data-driven algorithm for the spatial identification of localized events that is based on the following rationale: the distribution of emerging oscillations during confined events across all recording sites is highly non-uniform and can be mapped using a spatial entropy function. By applying this principle to EEG recording obtained from 67 distinct seizure epochs, our method successfully identified the seizure focus on a group of ten drug-resistant temporal lobe epilepsy patients (average sensitivity: 0.94, average specificity: 0.90) together with its characteristic electrophysiological pattern signature. Cross-validation of the method outputs with postresective information revealed the consistency of our findings in long follow-up seizure-free patients. Overall, our methodology provides a reliable computational procedure that might be used as in both experimental and clinical domains to identify the neural populations undergoing an emerging functional or pathological transition." @default.
• W2989696708 created "2019-12-05" @default.
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• W2989696708 date "2020-03-01" @default.
• W2989696708 modified "2023-10-10" @default.
• W2989696708 title "Low entropy map of brain oscillatory activity identifies spatially localized events: A new method for automated epilepsy focus prediction" @default.
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• W2989696708 doi "https://doi.org/10.1016/j.neuroimage.2019.116410" @default.
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