Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989701276> ?p ?o ?g. }
- W2989701276 endingPage "100816" @default.
- W2989701276 startingPage "100816" @default.
- W2989701276 abstract "Aromatase is the requisite and limiting enzyme in the production of estrogens from androgens. Estrogens synthesized centrally have more recently emerged as potent neuroprotectants in the vertebrate brain. Studies in rodents and songbirds have identified key mechanisms that underlie both; the injury-dependent induction of central aromatization, and the protective effects of centrally synthesized estrogens. Injury-induced aromatase expression in astrocytes occurs following a broad range of traumatic brain damage including excitotoxic, penetrating, and concussive injury. Responses to neural insult such as edema and inflammation involve signaling pathways the components of which are excellent candidates as inducers of this astrocytic response. Finally, estradiol from astrocytes exerts a paracrine neuroprotective influence via the potent inhibition of inflammatory pathways. Taken together, these data suggest a novel role for neural aromatization as a protective mechanism against the threat of inflammation and suggests that central estrogen provision is a wide-ranging neuroprotectant in the vertebrate brain." @default.
- W2989701276 created "2019-12-05" @default.
- W2989701276 creator A5047346561 @default.
- W2989701276 creator A5071815857 @default.
- W2989701276 date "2020-01-01" @default.
- W2989701276 modified "2023-10-18" @default.
- W2989701276 title "Central aromatization: A dramatic and responsive defense against threat and trauma to the vertebrate brain" @default.
- W2989701276 cites W1495111481 @default.
- W2989701276 cites W1503161932 @default.
- W2989701276 cites W1507094742 @default.
- W2989701276 cites W1550159293 @default.
- W2989701276 cites W1551831696 @default.
- W2989701276 cites W1563833920 @default.
- W2989701276 cites W1589710900 @default.
- W2989701276 cites W1600827637 @default.
- W2989701276 cites W1647805770 @default.
- W2989701276 cites W1862183284 @default.
- W2989701276 cites W1967066039 @default.
- W2989701276 cites W1968471467 @default.
- W2989701276 cites W1969291285 @default.
- W2989701276 cites W1970257032 @default.
- W2989701276 cites W1971233854 @default.
- W2989701276 cites W1971548442 @default.
- W2989701276 cites W1972368286 @default.
- W2989701276 cites W1973159494 @default.
- W2989701276 cites W1974268749 @default.
- W2989701276 cites W1976310340 @default.
- W2989701276 cites W1978278056 @default.
- W2989701276 cites W1979520552 @default.
- W2989701276 cites W1979673235 @default.
- W2989701276 cites W1980768491 @default.
- W2989701276 cites W1985622185 @default.
- W2989701276 cites W1988610853 @default.
- W2989701276 cites W1989518830 @default.
- W2989701276 cites W1993103674 @default.
- W2989701276 cites W1997131054 @default.
- W2989701276 cites W1998729879 @default.
- W2989701276 cites W1998878159 @default.
- W2989701276 cites W2007293272 @default.
- W2989701276 cites W2008050502 @default.
- W2989701276 cites W2008514814 @default.
- W2989701276 cites W2008525942 @default.
- W2989701276 cites W2009232518 @default.
- W2989701276 cites W2011398156 @default.
- W2989701276 cites W2011506847 @default.
- W2989701276 cites W2012080584 @default.
- W2989701276 cites W2016818296 @default.
- W2989701276 cites W2019291914 @default.
- W2989701276 cites W2020457210 @default.
- W2989701276 cites W2021036163 @default.
- W2989701276 cites W2021445727 @default.
- W2989701276 cites W2021612112 @default.
- W2989701276 cites W2021729084 @default.
- W2989701276 cites W2022159983 @default.
- W2989701276 cites W2022743236 @default.
- W2989701276 cites W2024631385 @default.
- W2989701276 cites W2025886909 @default.
- W2989701276 cites W2026464698 @default.
- W2989701276 cites W2027090292 @default.
- W2989701276 cites W2029746335 @default.
- W2989701276 cites W2030461772 @default.
- W2989701276 cites W2033711513 @default.
- W2989701276 cites W2034057116 @default.
- W2989701276 cites W2035077777 @default.
- W2989701276 cites W2036032721 @default.
- W2989701276 cites W2037007725 @default.
- W2989701276 cites W2040329969 @default.
- W2989701276 cites W2041873319 @default.
- W2989701276 cites W2042302140 @default.
- W2989701276 cites W2044032827 @default.
- W2989701276 cites W2045234653 @default.
- W2989701276 cites W2051214272 @default.
- W2989701276 cites W2052435478 @default.
- W2989701276 cites W2052499504 @default.
- W2989701276 cites W2056831005 @default.
- W2989701276 cites W2056843357 @default.
- W2989701276 cites W2057764884 @default.
- W2989701276 cites W2057955203 @default.
- W2989701276 cites W2059819603 @default.
- W2989701276 cites W2059983531 @default.
- W2989701276 cites W2061798428 @default.
- W2989701276 cites W2064750807 @default.
- W2989701276 cites W2064822762 @default.
- W2989701276 cites W2065239243 @default.
- W2989701276 cites W2065830665 @default.
- W2989701276 cites W2067448822 @default.
- W2989701276 cites W2067487401 @default.
- W2989701276 cites W2067622702 @default.
- W2989701276 cites W2069958394 @default.
- W2989701276 cites W2071918649 @default.
- W2989701276 cites W2072449323 @default.
- W2989701276 cites W2072735944 @default.
- W2989701276 cites W2073394581 @default.
- W2989701276 cites W2075990267 @default.
- W2989701276 cites W2078577857 @default.
- W2989701276 cites W2079131443 @default.
- W2989701276 cites W2081540673 @default.
- W2989701276 cites W2082406831 @default.