FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989710029> ?p ?o ?g. }

• W2989710029 endingPage "4" @default.
• W2989710029 startingPage "1" @default.
• W2989710029 abstract "Background and Aims: The liver is the first organ affected by toxic copper in the classical and severe hepatic forms of Wilson's disease (WD). Because their associated chronic liver damage is mostly asymptomatic, an intervention using a special test including serum alanine aminotransferase (ALT) activity is needed for detecting WD. Methods: Using the modified international criteria for the diagnosis of WD, 45 patients were selected from the collective databases of our institutions, and 7 infants were reviewed from the literature. Two patients had the severe hepatic form, with normoceruloplasminemia and no mutations in ATP7B. The rapid ALT change during hemolytic anemia was adjusted for a baseline. The diagnostic potential of the ALT test was assessed from the age-dependent natural course of the liver damage of WD. Results: The natural course had three stages. ALTs were still low in some infants younger than 4 years-old. They were high in all children between the ages of 4 and 8 years-old; then, they reduced to low levels in some patients over 9 years of age. The high ALT stage represents chronic active hepatitis, and the subsequent low ALT stage is due to silent cirrhosis. The hepatic copper content is a reliable but invasive test, while urinary copper secretion is an alternative, non-invasive test for copper toxicosis of WD. The serum ceruloplasmin and ATP7B analyses are subtype tests of WD. The response to anti-copper regimens is the final test result. Conclusions: ALT could be the first parameter to test to detect WD in children between the ages of 4 and 8 years." @default.
• W2989710029 created "2019-12-05" @default.
• W2989710029 creator A5011575162 @default.
• W2989710029 creator A5012940655 @default.
• W2989710029 creator A5024117802 @default.
• W2989710029 creator A5049642090 @default.
• W2989710029 creator A5050186494 @default.
• W2989710029 creator A5054121299 @default.
• W2989710029 creator A5082228691 @default.
• W2989710029 creator A5084410022 @default.
• W2989710029 date "2019-11-29" @default.
• W2989710029 modified "2023-09-27" @default.
• W2989710029 title "Alanine Aminotransferase as the First Test Parameter for Wilson’s Disease" @default.
• W2989710029 cites W1121934921 @default.
• W2989710029 cites W116600519 @default.
• W2989710029 cites W1454220380 @default.
• W2989710029 cites W1531052070 @default.
• W2989710029 cites W180631047 @default.
• W2989710029 cites W1922806981 @default.
• W2989710029 cites W1996610030 @default.
• W2989710029 cites W2026126173 @default.
• W2989710029 cites W2036188709 @default.
• W2989710029 cites W2055433364 @default.
• W2989710029 cites W2063561285 @default.
• W2989710029 cites W2064635652 @default.
• W2989710029 cites W2084981545 @default.
• W2989710029 cites W2107472512 @default.
• W2989710029 cites W2120805372 @default.
• W2989710029 cites W2152364847 @default.
• W2989710029 cites W2170535029 @default.
• W2989710029 cites W2402709190 @default.
• W2989710029 cites W2411109624 @default.
• W2989710029 cites W253822838 @default.
• W2989710029 cites W2607657572 @default.
• W2989710029 cites W2767798137 @default.
• W2989710029 cites W2807522150 @default.
• W2989710029 cites W67878095 @default.
• W2989710029 cites W8570163 @default.
• W2989710029 doi "https://doi.org/10.14218/jcth.2019.00042" @default.
• W2989710029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6943216" @default.
• W2989710029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31915597" @default.
• W2989710029 hasPublicationYear "2019" @default.
• W2989710029 type Work @default.
• W2989710029 sameAs 2989710029 @default.
• W2989710029 citedByCount "2" @default.
• W2989710029 countsByYear W29897100292022 @default.
• W2989710029 crossrefType "journal-article" @default.
• W2989710029 hasAuthorship W2989710029A5011575162 @default.
• W2989710029 hasAuthorship W2989710029A5012940655 @default.
• W2989710029 hasAuthorship W2989710029A5024117802 @default.
• W2989710029 hasAuthorship W2989710029A5049642090 @default.
• W2989710029 hasAuthorship W2989710029A5050186494 @default.
• W2989710029 hasAuthorship W2989710029A5054121299 @default.
• W2989710029 hasAuthorship W2989710029A5082228691 @default.
• W2989710029 hasAuthorship W2989710029A5084410022 @default.
• W2989710029 hasBestOaLocation W29897100291 @default.
• W2989710029 hasConcept C126322002 @default.
• W2989710029 hasConcept C2776231509 @default.
• W2989710029 hasConcept C2777075537 @default.
• W2989710029 hasConcept C2777214474 @default.
• W2989710029 hasConcept C2777910003 @default.
• W2989710029 hasConcept C2779134260 @default.
• W2989710029 hasConcept C28452662 @default.
• W2989710029 hasConcept C2992872382 @default.
• W2989710029 hasConcept C512861765 @default.
• W2989710029 hasConcept C71924100 @default.
• W2989710029 hasConcept C90924648 @default.
• W2989710029 hasConceptScore W2989710029C126322002 @default.
• W2989710029 hasConceptScore W2989710029C2776231509 @default.
• W2989710029 hasConceptScore W2989710029C2777075537 @default.
• W2989710029 hasConceptScore W2989710029C2777214474 @default.
• W2989710029 hasConceptScore W2989710029C2777910003 @default.
• W2989710029 hasConceptScore W2989710029C2779134260 @default.
• W2989710029 hasConceptScore W2989710029C28452662 @default.
• W2989710029 hasConceptScore W2989710029C2992872382 @default.
• W2989710029 hasConceptScore W2989710029C512861765 @default.
• W2989710029 hasConceptScore W2989710029C71924100 @default.
• W2989710029 hasConceptScore W2989710029C90924648 @default.
• W2989710029 hasIssue "X" @default.
• W2989710029 hasLocation W29897100291 @default.
• W2989710029 hasLocation W29897100292 @default.
• W2989710029 hasLocation W29897100293 @default.
• W2989710029 hasLocation W29897100294 @default.
• W2989710029 hasOpenAccess W2989710029 @default.
• W2989710029 hasPrimaryLocation W29897100291 @default.
• W2989710029 hasRelatedWork W1986152242 @default.
• W2989710029 hasRelatedWork W2062575314 @default.
• W2989710029 hasRelatedWork W2106326535 @default.
• W2989710029 hasRelatedWork W2111039221 @default.
• W2989710029 hasRelatedWork W2120918830 @default.
• W2989710029 hasRelatedWork W2363002749 @default.
• W2989710029 hasRelatedWork W2606504963 @default.
• W2989710029 hasRelatedWork W3136394023 @default.
• W2989710029 hasRelatedWork W3185565822 @default.
• W2989710029 hasRelatedWork W4220993175 @default.
• W2989710029 hasVolume "7" @default.
• W2989710029 isParatext "false" @default.
• W2989710029 isRetracted "false" @default.

• next