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- W2989710681 abstract "Objective:To study the therapeutic effect of betaine on alcoholic liver disease in rats and investigate its potential mechanism. Methods:The rat alcoholic liver disease model was made by feeding alcohol for 4 weeks.Then betaine was administered tothese rats in a dose of 200,400 and 800 mg/kg for 4 weeks in which the content of serum total homocysteine(tHcy),serum aminotransferase activity(ALT,AST),the level of MDA,GSH in hepatic tissues were measured,the hepatic histological change were observed. Results:The level of serum tHcy,ALT,AST and hepatic tissue contents of MDA in betaine treated groups were significantly decreased(P<0.05),while the level of GSH was significantly increased as compared with that in the model group(P <0.05). Moreover:The histological evaluation of liver demonstrated that betaine dramatically decreased lipid accumulation and inflammatory cells infiltration. Conclusion:Betaine is effective in treating rats alcoholic liver disease,and its main mechanisms might be related to reduction of correcting methionine circulation anomalies and sulfonium function abnormal." @default.
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- W2989710681 date "2014-01-01" @default.
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- W2989710681 title "Therapeutic effect of betaine on alcoholic liver disease in rats" @default.
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