FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W29897128> ?p ?o ?g. }

• W29897128 endingPage "532" @default.
• W29897128 startingPage "525" @default.
• W29897128 abstract "The Three Rs are the main principles used by Animal Ethics Committees in the governance of animal experimentation, but they appear not to cover some ethical issues that arise today. These include: a) claims that certain species should be exempted on principle from harmful research; b) increased emphasis on enhancing quality of life of research animals; c) research involving genetically modified (GM) animals; and d) animals bred as models of disease. In some cases, the Three Rs can be extended to cover these developments. The burgeoning use of GM animals in science calls for new forms of reduction through improved genetic modification technology, plus continued attention to alternative approaches and cost–benefit analyses that include the large numbers of animals involved indirectly. The adoption of more expanded definitions of refinement that go beyond minimising distress will capture concerns for enhancing the quality of life of animals through improved husbandry and handling. Targeting refinement to the unpredictable effects of gene modification may be difficult; in these cases, careful attention to monitoring and endpoints are the obvious options. Refinement can also include sharing data about the welfare impacts of gene modifications, and modelling earlier stages of disease, in order to reduce the potential suffering caused to disease models. Other issues may require a move beyond the Three Rs. Certain levels of harm, or numbers and use of certain species, may be unacceptable, regardless of potential benefits. This can be addressed by supplementing the utilitarian basis of the Three Rs with principles based on deontological and relational ethics. The Three Rs remain very useful, but they require thoughtful interpretation and expansion in order for Animal Ethics Committees to address the full range of issues in animal-based research." @default.
• W29897128 created "2016-06-24" @default.
• W29897128 creator A5038650047 @default.
• W29897128 creator A5043813168 @default.
• W29897128 creator A5061303796 @default.
• W29897128 date "2004-11-01" @default.
• W29897128 modified "2023-10-15" @default.
• W29897128 title "Expanding the Three Rs to Meet New Challenges in Humane Animal Experimentation" @default.
• W29897128 cites W1769796785 @default.
• W29897128 cites W196769061 @default.
• W29897128 cites W1988530667 @default.
• W29897128 cites W2013670696 @default.
• W29897128 cites W2031508158 @default.
• W29897128 cites W2059845269 @default.
• W29897128 cites W2105482499 @default.
• W29897128 cites W2120623141 @default.
• W29897128 cites W2121157101 @default.
• W29897128 cites W2122085902 @default.
• W29897128 cites W2126320339 @default.
• W29897128 cites W2134581723 @default.
• W29897128 cites W2397455915 @default.
• W29897128 cites W2399947190 @default.
• W29897128 cites W4315566830 @default.
• W29897128 doi "https://doi.org/10.1177/026119290403200507" @default.
• W29897128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15656775" @default.
• W29897128 hasPublicationYear "2004" @default.
• W29897128 type Work @default.
• W29897128 sameAs 29897128 @default.
• W29897128 citedByCount "47" @default.
• W29897128 countsByYear W298971282012 @default.
• W29897128 countsByYear W298971282013 @default.
• W29897128 countsByYear W298971282014 @default.
• W29897128 countsByYear W298971282015 @default.
• W29897128 countsByYear W298971282016 @default.
• W29897128 countsByYear W298971282017 @default.
• W29897128 countsByYear W298971282018 @default.
• W29897128 countsByYear W298971282019 @default.
• W29897128 countsByYear W298971282020 @default.
• W29897128 countsByYear W298971282021 @default.
• W29897128 countsByYear W298971282022 @default.
• W29897128 countsByYear W298971282023 @default.
• W29897128 crossrefType "journal-article" @default.
• W29897128 hasAuthorship W29897128A5038650047 @default.
• W29897128 hasAuthorship W29897128A5043813168 @default.
• W29897128 hasAuthorship W29897128A5061303796 @default.
• W29897128 hasBestOaLocation W298971281 @default.
• W29897128 hasConcept C10138342 @default.
• W29897128 hasConcept C111472728 @default.
• W29897128 hasConcept C112930515 @default.
• W29897128 hasConcept C127413603 @default.
• W29897128 hasConcept C138885662 @default.
• W29897128 hasConcept C144133560 @default.
• W29897128 hasConcept C15744967 @default.
• W29897128 hasConcept C17744445 @default.
• W29897128 hasConcept C18903297 @default.
• W29897128 hasConcept C199539241 @default.
• W29897128 hasConcept C2777102381 @default.
• W29897128 hasConcept C2777363581 @default.
• W29897128 hasConcept C2779530757 @default.
• W29897128 hasConcept C39389867 @default.
• W29897128 hasConcept C41008148 @default.
• W29897128 hasConcept C520753416 @default.
• W29897128 hasConcept C523966790 @default.
• W29897128 hasConcept C55587333 @default.
• W29897128 hasConcept C77805123 @default.
• W29897128 hasConcept C86803240 @default.
• W29897128 hasConceptScore W29897128C10138342 @default.
• W29897128 hasConceptScore W29897128C111472728 @default.
• W29897128 hasConceptScore W29897128C112930515 @default.
• W29897128 hasConceptScore W29897128C127413603 @default.
• W29897128 hasConceptScore W29897128C138885662 @default.
• W29897128 hasConceptScore W29897128C144133560 @default.
• W29897128 hasConceptScore W29897128C15744967 @default.
• W29897128 hasConceptScore W29897128C17744445 @default.
• W29897128 hasConceptScore W29897128C18903297 @default.
• W29897128 hasConceptScore W29897128C199539241 @default.
• W29897128 hasConceptScore W29897128C2777102381 @default.
• W29897128 hasConceptScore W29897128C2777363581 @default.
• W29897128 hasConceptScore W29897128C2779530757 @default.
• W29897128 hasConceptScore W29897128C39389867 @default.
• W29897128 hasConceptScore W29897128C41008148 @default.
• W29897128 hasConceptScore W29897128C520753416 @default.
• W29897128 hasConceptScore W29897128C523966790 @default.
• W29897128 hasConceptScore W29897128C55587333 @default.
• W29897128 hasConceptScore W29897128C77805123 @default.
• W29897128 hasConceptScore W29897128C86803240 @default.
• W29897128 hasIssue "5" @default.
• W29897128 hasLocation W298971281 @default.
• W29897128 hasLocation W298971282 @default.
• W29897128 hasOpenAccess W29897128 @default.
• W29897128 hasPrimaryLocation W298971281 @default.
• W29897128 hasRelatedWork W108462188 @default.
• W29897128 hasRelatedWork W1422642887 @default.
• W29897128 hasRelatedWork W2136885759 @default.
• W29897128 hasRelatedWork W2739378288 @default.
• W29897128 hasRelatedWork W2886114293 @default.
• W29897128 hasRelatedWork W2895941609 @default.
• W29897128 hasRelatedWork W4285530493 @default.

• next