Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989714690> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2989714690 endingPage "4514" @default.
- W2989714690 startingPage "4514" @default.
- W2989714690 abstract "Because of the ubiquitous presence and the extensive use of parabensand other phenolic substances (like triclosan, triclocarban or benzophenones) in personal care and consumer products, food and beverage processing, pharmaceuticals and disinfectants humans are constantly exposed to these substances. Some of these substances are suspected to affect the endocrine system of humans. The German Environmental Specimen Bank (ESBHum) – supervised and scientifically coordinated by the German Federal Environment Agency (UBA) – archives human specimens since 1985 and thus allows assessing trends of human exposure. We quantified the body burden to these substances (9 parabens and 6 other phenolic substances) by analyzing 660 urine samples of the ESBHum (24h-urines) from the years 1995, 1997, 1999, 2001, 2003, 2005-2009 and 2012; 60 samples per year, from 30 male and 30 female volunteers (age: 21-29 years). We applied a newly developed highly sensitive on-line HPLC-MS/MS method, for the determination of these substances in urine. Analytical limits of quantification were in the range from 0.5 to 2 µg/L. The total concentration of the analytes (free and conjugated species) was measured. All samples were blinded before analysis. In nearly all samples parabens could be quantified.Median concentrations over the different years were around 40 µg/L for methyl-, 2 µg/L for ethyl- and 5 µg/L for n-propyl paraben. For the parabens this mainly reflects their consumption volume being highest for methyl paraben, followed by ethyl-, propyl- and butyl paraben. Triclosan was detected in around 60% of all samples analyzed. Median benzophenone-3 levels fell from around 2.5 µg/L (1995-2003) to < LOQ (2005-2012). For all other analytes medians are below the LOQ. Over the years we observed rather constant levels of exposures, except for the decrease in benzophenone-3. This retrospective study provides first data on internal exposures to the above substances in Germany from 1995 till 2012." @default.
- W2989714690 created "2019-12-05" @default.
- W2989714690 creator A5013971699 @default.
- W2989714690 creator A5016414214 @default.
- W2989714690 creator A5028375247 @default.
- W2989714690 creator A5059501293 @default.
- W2989714690 creator A5070626446 @default.
- W2989714690 creator A5079258290 @default.
- W2989714690 date "2013-09-19" @default.
- W2989714690 modified "2023-10-18" @default.
- W2989714690 title "Parabens and other phenols in urine samples of the German Environmental Specimen Bank (ESBHum) from 1995 to 2012: a retrospective exposure assessment" @default.
- W2989714690 doi "https://doi.org/10.1289/isee.2013.o-3-35-02" @default.
- W2989714690 hasPublicationYear "2013" @default.
- W2989714690 type Work @default.
- W2989714690 sameAs 2989714690 @default.
- W2989714690 citedByCount "0" @default.
- W2989714690 crossrefType "journal-article" @default.
- W2989714690 hasAuthorship W2989714690A5013971699 @default.
- W2989714690 hasAuthorship W2989714690A5016414214 @default.
- W2989714690 hasAuthorship W2989714690A5028375247 @default.
- W2989714690 hasAuthorship W2989714690A5059501293 @default.
- W2989714690 hasAuthorship W2989714690A5070626446 @default.
- W2989714690 hasAuthorship W2989714690A5079258290 @default.
- W2989714690 hasConcept C107872376 @default.
- W2989714690 hasConcept C142724271 @default.
- W2989714690 hasConcept C178790620 @default.
- W2989714690 hasConcept C185592680 @default.
- W2989714690 hasConcept C2778500651 @default.
- W2989714690 hasConcept C2779370918 @default.
- W2989714690 hasConcept C2779717098 @default.
- W2989714690 hasConcept C2780026642 @default.
- W2989714690 hasConcept C2781289450 @default.
- W2989714690 hasConcept C31903555 @default.
- W2989714690 hasConcept C33070731 @default.
- W2989714690 hasConcept C43617362 @default.
- W2989714690 hasConcept C55493867 @default.
- W2989714690 hasConcept C67031304 @default.
- W2989714690 hasConcept C71924100 @default.
- W2989714690 hasConcept C86803240 @default.
- W2989714690 hasConceptScore W2989714690C107872376 @default.
- W2989714690 hasConceptScore W2989714690C142724271 @default.
- W2989714690 hasConceptScore W2989714690C178790620 @default.
- W2989714690 hasConceptScore W2989714690C185592680 @default.
- W2989714690 hasConceptScore W2989714690C2778500651 @default.
- W2989714690 hasConceptScore W2989714690C2779370918 @default.
- W2989714690 hasConceptScore W2989714690C2779717098 @default.
- W2989714690 hasConceptScore W2989714690C2780026642 @default.
- W2989714690 hasConceptScore W2989714690C2781289450 @default.
- W2989714690 hasConceptScore W2989714690C31903555 @default.
- W2989714690 hasConceptScore W2989714690C33070731 @default.
- W2989714690 hasConceptScore W2989714690C43617362 @default.
- W2989714690 hasConceptScore W2989714690C55493867 @default.
- W2989714690 hasConceptScore W2989714690C67031304 @default.
- W2989714690 hasConceptScore W2989714690C71924100 @default.
- W2989714690 hasConceptScore W2989714690C86803240 @default.
- W2989714690 hasIssue "1" @default.
- W2989714690 hasLocation W29897146901 @default.
- W2989714690 hasOpenAccess W2989714690 @default.
- W2989714690 hasPrimaryLocation W29897146901 @default.
- W2989714690 hasRelatedWork W1911267016 @default.
- W2989714690 hasRelatedWork W1978998197 @default.
- W2989714690 hasRelatedWork W2014457168 @default.
- W2989714690 hasRelatedWork W2022759827 @default.
- W2989714690 hasRelatedWork W2025303652 @default.
- W2989714690 hasRelatedWork W2071696415 @default.
- W2989714690 hasRelatedWork W2735963495 @default.
- W2989714690 hasRelatedWork W2934620548 @default.
- W2989714690 hasRelatedWork W3135823152 @default.
- W2989714690 hasRelatedWork W4206139295 @default.
- W2989714690 hasVolume "2013" @default.
- W2989714690 isParatext "false" @default.
- W2989714690 isRetracted "false" @default.
- W2989714690 magId "2989714690" @default.
- W2989714690 workType "article" @default.