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- W2989726504 abstract "Danio rerio (zebrafish) is an elective model organism for the study of vertebrate development because of its high degree of homology with human genes and organs, including bone. Zebrafish embryos, because of the optical clarity, small size, and fast development, can be easily used in large-scale mutagenesis experiments to isolate mutants with developmental skeletal defects and in high-throughput screenings to find new chemical compounds for the ability to revert the pathological phenotype. On the other hand, the adult zebrafish represents another powerful resource for pathogenic and therapeutic studies about adult human bone diseases. In fish, some characteristics such as bone turnover, reparation, and remodeling of the adult bone tissue cannot be found at the embryonic stage. Several pathological models have been established in adult zebrafish such as bone injury models, osteoporosis, and genetic diseases such as osteogenesis imperfecta. Given the growing interest for metabolic diseases and their complications, adult zebrafish models of type 2 diabetes and obesity have been recently generated and analyzed for bone complications using scales as model system. Interestingly, an osteoporosis-like phenotype has been found to be associated with metabolic alterations suggesting that bone complications share the same mechanisms in humans and fish. Embryo and adult represent powerful resources in rapid development to study bone physiology and pathology from different points of view." @default.
- W2989726504 created "2019-12-05" @default.
- W2989726504 creator A5019823078 @default.
- W2989726504 creator A5044668109 @default.
- W2989726504 creator A5059620963 @default.
- W2989726504 date "2019-11-20" @default.
- W2989726504 modified "2023-10-11" @default.
- W2989726504 title "Zebrafish Models of Human Skeletal Disorders: Embryo and Adult Swimming Together" @default.
- W2989726504 cites W1485932716 @default.
- W2989726504 cites W1539324883 @default.
- W2989726504 cites W1603250162 @default.
- W2989726504 cites W1615535881 @default.
- W2989726504 cites W1836388554 @default.
- W2989726504 cites W1875883743 @default.
- W2989726504 cites W1930957416 @default.
- W2989726504 cites W1965172675 @default.
- W2989726504 cites W1965301846 @default.
- W2989726504 cites W1968446517 @default.
- W2989726504 cites W1975940953 @default.
- W2989726504 cites W1979637071 @default.
- W2989726504 cites W1982700114 @default.
- W2989726504 cites W1987457965 @default.
- W2989726504 cites W1993002923 @default.
- W2989726504 cites W1994982119 @default.
- W2989726504 cites W1994985807 @default.
- W2989726504 cites W1996517063 @default.
- W2989726504 cites W2003831633 @default.
- W2989726504 cites W2015261096 @default.
- W2989726504 cites W2017178662 @default.
- W2989726504 cites W2019088820 @default.
- W2989726504 cites W2019816362 @default.
- W2989726504 cites W2022281569 @default.
- W2989726504 cites W2025327047 @default.
- W2989726504 cites W2028298873 @default.
- W2989726504 cites W2029344996 @default.
- W2989726504 cites W2031138050 @default.
- W2989726504 cites W2034017564 @default.
- W2989726504 cites W2035401612 @default.
- W2989726504 cites W2040328099 @default.
- W2989726504 cites W2059470587 @default.
- W2989726504 cites W2061013008 @default.
- W2989726504 cites W2065424117 @default.
- W2989726504 cites W2069073705 @default.
- W2989726504 cites W2070338056 @default.
- W2989726504 cites W2074412639 @default.
- W2989726504 cites W2077742100 @default.
- W2989726504 cites W2078180186 @default.
- W2989726504 cites W2084341282 @default.
- W2989726504 cites W2090195805 @default.
- W2989726504 cites W2090576305 @default.
- W2989726504 cites W2092707782 @default.
- W2989726504 cites W2095115438 @default.
- W2989726504 cites W2098216187 @default.
- W2989726504 cites W2099899109 @default.
- W2989726504 cites W2100361265 @default.
- W2989726504 cites W2101996435 @default.
- W2989726504 cites W2104542540 @default.
- W2989726504 cites W2104632163 @default.
- W2989726504 cites W2108833058 @default.
- W2989726504 cites W2111609646 @default.
- W2989726504 cites W2118381565 @default.
- W2989726504 cites W2121554092 @default.
- W2989726504 cites W2127493628 @default.
- W2989726504 cites W2128448507 @default.
- W2989726504 cites W2129160809 @default.
- W2989726504 cites W2131133382 @default.
- W2989726504 cites W2131892618 @default.
- W2989726504 cites W2135843934 @default.
- W2989726504 cites W213851330 @default.
- W2989726504 cites W2138591901 @default.
- W2989726504 cites W2139915950 @default.
- W2989726504 cites W2144954949 @default.
- W2989726504 cites W2147477158 @default.
- W2989726504 cites W2155990454 @default.
- W2989726504 cites W2160134323 @default.
- W2989726504 cites W2164939521 @default.
- W2989726504 cites W2165400076 @default.
- W2989726504 cites W2167565365 @default.
- W2989726504 cites W2169127853 @default.
- W2989726504 cites W2169474931 @default.
- W2989726504 cites W2181676466 @default.
- W2989726504 cites W2187201038 @default.
- W2989726504 cites W2229719906 @default.
- W2989726504 cites W2268086000 @default.
- W2989726504 cites W2368437445 @default.
- W2989726504 cites W2397764234 @default.
- W2989726504 cites W2464200499 @default.
- W2989726504 cites W2470439141 @default.
- W2989726504 cites W2524235889 @default.
- W2989726504 cites W2553294090 @default.
- W2989726504 cites W2555414731 @default.
- W2989726504 cites W2560154047 @default.
- W2989726504 cites W2566558413 @default.
- W2989726504 cites W2568656550 @default.
- W2989726504 cites W2578489247 @default.
- W2989726504 cites W2591890510 @default.
- W2989726504 cites W2611771012 @default.
- W2989726504 cites W2611783013 @default.