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- W2989726717 abstract "Varied intracellular pH levels are critical for various physiological processes such as enzymatic activity, cell proliferation and apoptosis, ion transport, and muscle contraction. Cellular compartments, like lysosomes, must retain an acidic environment (pH ~ 4.5) to activate hydrolytic enzymes necessary for the breakdown of large biomolecules. Another cellular organelle, the mitochondria, provides the cell with energy and must retain an alkalis environment (pH ~ 8.0) for proper function. Substantial lysosomal and mitochondrial pH deviation is associated with cellular dysfunction and disease. Therefore, the precise detection of lysosomal and mitochondrial pH is essential to provide a better understanding of cellular physiological and pathological processes. Due to their superior features, such as cheap and simple operation, high spatial and temporal resolution, and noninvasive fluorescence imaging, fluorescent probes are the ideal methodology to visualize and monitor lysosomal and mitochondrial pH variation." @default.
- W2989726717 created "2019-12-05" @default.
- W2989726717 creator A5022263832 @default.
- W2989726717 date "2020-12-10" @default.
- W2989726717 modified "2023-10-03" @default.
- W2989726717 title "NEAR-INFRARED FLUORESCENT PROBES FOR SENSITIVE DETERMINATION OF LYSOSOMAL & MITOCHONDRIAL pH IN LIVE CELLS" @default.
- W2989726717 doi "https://doi.org/10.37099/mtu.dc.etdr/899" @default.
- W2989726717 hasPublicationYear "2020" @default.
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