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- W2989741456 endingPage "1536" @default.
- W2989741456 startingPage "1536" @default.
- W2989741456 abstract "Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all the cardiac lineages. These cells offer a significant shift in paradigm over the use of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes owing to the latter’s inability to recapitulate mature features of a native myocardium, limiting their translational applications. The iPSCs and direct reprogramming of somatic cells have been attempted to produce CPCs and, in this process, a variety of chemical and/or genetic factors have been evaluated for their ability to generate, expand, and maintain CPCs in vitro. However, the precise stoichiometry and spatiotemporal activity of these factors and the genetic interplay during embryonic CPC development remain challenging to reproduce in culture, in terms of efficiency, numbers, and translational potential. Recent advances in biomaterials to mimic the native cardiac microenvironment have shown promise to influence CPC regenerative functions, while being capable of integrating with host tissue. This review highlights recent developments and limitations in the generation and use of CPCs from stem cells, and the trends that influence the direction of research to promote better application of CPCs." @default.
- W2989741456 created "2019-12-05" @default.
- W2989741456 creator A5010945376 @default.
- W2989741456 creator A5012139112 @default.
- W2989741456 creator A5016976971 @default.
- W2989741456 creator A5049108649 @default.
- W2989741456 creator A5060387032 @default.
- W2989741456 date "2019-11-28" @default.
- W2989741456 modified "2023-10-05" @default.
- W2989741456 title "Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials" @default.
- W2989741456 cites W1109775121 @default.
- W2989741456 cites W1161105111 @default.
- W2989741456 cites W1174010745 @default.
- W2989741456 cites W1480171680 @default.
- W2989741456 cites W1483167997 @default.
- W2989741456 cites W1519332939 @default.
- W2989741456 cites W1669479280 @default.
- W2989741456 cites W1807741646 @default.
- W2989741456 cites W1866852956 @default.
- W2989741456 cites W1899971349 @default.
- W2989741456 cites W1901119904 @default.
- W2989741456 cites W1945633248 @default.
- W2989741456 cites W1963756072 @default.
- W2989741456 cites W1964614677 @default.
- W2989741456 cites W1966563415 @default.
- W2989741456 cites W1968099944 @default.
- W2989741456 cites W1968123453 @default.
- W2989741456 cites W1968360368 @default.
- W2989741456 cites W1969193847 @default.
- W2989741456 cites W1973807810 @default.
- W2989741456 cites W1974388426 @default.
- W2989741456 cites W1976039481 @default.
- W2989741456 cites W1977015206 @default.
- W2989741456 cites W1977025496 @default.
- W2989741456 cites W1978017776 @default.
- W2989741456 cites W1981591120 @default.
- W2989741456 cites W1982531169 @default.
- W2989741456 cites W1982736212 @default.
- W2989741456 cites W1982815250 @default.
- W2989741456 cites W1984296192 @default.
- W2989741456 cites W1984693113 @default.
- W2989741456 cites W1984778391 @default.
- W2989741456 cites W1985311481 @default.
- W2989741456 cites W1986821244 @default.
- W2989741456 cites W1987153030 @default.
- W2989741456 cites W1987304070 @default.
- W2989741456 cites W1987774343 @default.
- W2989741456 cites W1987970488 @default.
- W2989741456 cites W1988451304 @default.
- W2989741456 cites W1989420473 @default.
- W2989741456 cites W1990484902 @default.
- W2989741456 cites W1991533533 @default.
- W2989741456 cites W1991838646 @default.
- W2989741456 cites W1991978261 @default.
- W2989741456 cites W1993554607 @default.
- W2989741456 cites W1993813857 @default.
- W2989741456 cites W1993932646 @default.
- W2989741456 cites W1994083955 @default.
- W2989741456 cites W1994387772 @default.
- W2989741456 cites W1996834269 @default.
- W2989741456 cites W1997987443 @default.
- W2989741456 cites W1999881610 @default.
- W2989741456 cites W2000564041 @default.
- W2989741456 cites W2001142378 @default.
- W2989741456 cites W2001356111 @default.
- W2989741456 cites W2001356598 @default.
- W2989741456 cites W2002115156 @default.
- W2989741456 cites W2002697835 @default.
- W2989741456 cites W2003756136 @default.
- W2989741456 cites W2003956633 @default.
- W2989741456 cites W2005242898 @default.
- W2989741456 cites W2006028524 @default.
- W2989741456 cites W2008016893 @default.
- W2989741456 cites W2010368308 @default.
- W2989741456 cites W2010417854 @default.
- W2989741456 cites W2011844821 @default.
- W2989741456 cites W2012154384 @default.
- W2989741456 cites W2013459705 @default.
- W2989741456 cites W2018560113 @default.
- W2989741456 cites W2020637018 @default.
- W2989741456 cites W2020702297 @default.
- W2989741456 cites W2022688874 @default.
- W2989741456 cites W2023212613 @default.
- W2989741456 cites W2024174149 @default.
- W2989741456 cites W2024323808 @default.
- W2989741456 cites W2024911623 @default.
- W2989741456 cites W2025899080 @default.
- W2989741456 cites W2026268864 @default.
- W2989741456 cites W2027134089 @default.
- W2989741456 cites W2028036560 @default.
- W2989741456 cites W2028989717 @default.
- W2989741456 cites W2030395462 @default.
- W2989741456 cites W2032241627 @default.
- W2989741456 cites W2033884907 @default.
- W2989741456 cites W2034686467 @default.
- W2989741456 cites W2035006418 @default.
- W2989741456 cites W2035312069 @default.
- W2989741456 cites W2035708591 @default.