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- W2989743350 abstract "Introduction: During prenatal development, gonadal hormones can influence sexually dimorphic behaviors, like visual-spatial abilities during childhood. Thus, chemicals that affect gonadal hormones during gestation may affect these behaviors. We investigated the relationship of prenatal phthalate, triclosan, and BPA exposures with visualspatial abilities in 198 children. Methods: Data were from a prospective birth cohort in Cincinnati, OH. We quantified nine phthalate metabolites, BPA, and triclosan in maternal urine collected at 16 and 26 weeks gestation. We assessed children’s visual-spatial abilities at 8 years of age using the Virtual Morris Water Maze (VMWM), a computerized version of a rodent visualspatial test. We estimated the covariate-adjusted change in the time and distance to complete the VMWM with an interquartile range (IQR) increase in chemical concentrations using linear mixed models. Results: Boys completed the VMWM faster (-4.1 seconds; 95% CI:-7.1, -1.2) and in less distance (-1.4 units; 95% CI:-2.8, 0) than girls. Mono-n-butyl (MnBP), mono-benzyl (MBzP), and mono-carboxypropyl phthalate concentrations were associated with reduced distance and time to complete the VMWM. For example, MBzP levels were associated with completing the VMWM 1.4 seconds faster (95% CI:-3.3, 0.5) and in 1.1 less distance units (95% CI:-2.0, -0.2). Child sex modified the association between MnBP and VMWM performance (interaction p-values<0.05) where MnBP levels were associated with longer time (3.5 seconds; 95% CI:-1.6, 8.7) and shorter distance (-3.6 units; 95% CI:-1.1, -6.1) in girls. In boys, MnBP concentrations were associated with shorter time (-6.2 seconds; 95% CI:-12, -0.6), but not distance (-0.3 units; 95% CI:-2.8, 2.2). Other phthalates, triclosan, and BPA were not associated with VMWM performance and sex did not modify these associations. Conclusions: In this cohort, prenatal urinary concentrations of some phthalates were associated with improved VMWM performance." @default.
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- W2989743350 date "2016-08-17" @default.
- W2989743350 modified "2023-09-28" @default.
- W2989743350 title "Are Child Visual-Spatial Abilities Related to Prenatal Phthalate, Triclosan, or Bisphenol A Exposures?" @default.
- W2989743350 doi "https://doi.org/10.1289/isee.2016.3100" @default.
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