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• W2989744945 abstract "Cross-sectional studies have suggested that cortical atrophy on MRI occur years before symptom onset in asymptomatic MAPT mutation carriers. The trajectory of changes in brain structure on longitudinal MRI is not established asymptomatic MAPT mutation carriers. The objective of this study was to investigate the rates of lobar cortical atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutations carriers. MAPT mutation carriers (n=12; 8 asymptomatic, 4 converters from asymptomatic to symptomatic) and non-carriers (n=8) underwent structural MRI and were followed annually clinical examination at the time of MR examination, including a medical history review, mental status examination, a neurological and a neuropsychological examination. Participants were followed for a median of 8.7 years (range 3.8 to 10.7 years) and had at least 2 MRI scans, with a total of 126 MRI examinations. For the region-level analysis, we applied tensor-based morphometry with symmetric normalization (TBM-SyN) to compute the baseline lobar cortical volumes and changes over time in each participant. We modeled the log of lobar cortical volumes to estimate rate of volume loss expressed as percentage per year using linear mixed-effect models with random subject-specific intercepts and slopes. There were no differences between the 3 groups at baseline based on sex, education, age at initial MRI scan and cognitive scores. The rate of temporal lobe atrophy in asymptomatic MAPT mutation carriers was faster than non-carriers (p <0.001). Although the greatest rate of atrophy was observed in the temporal lobes in converters (p <0.001), they also had increased atrophy rates in the frontal (p <0.05) and parietal (p <0.05) lobes compared to non-carriers (Figure 1)." @default.
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• W2989744945 date "2019-07-01" @default.
• W2989744945 modified "2023-09-23" @default.
• W2989744945 title "P3-364: RATES OF LOBAR ATROPHY IN ASYMPTOMATIC MAPT MUTATION CARRIERS" @default.
• W2989744945 doi "https://doi.org/10.1016/j.jalz.2019.06.3397" @default.
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