Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989748078> ?p ?o ?g. }
- W2989748078 abstract "Primordial germ cells (PGCs) are the precursors to the adult germline stem cells that are set aside early during embryogenesis and specified through the inheritance of the germ plasm, which contains the mRNAs and proteins that function as the germline fate determinants. In Drosophila melanogaster, formation of the PGCs requires the microtubule and actin cytoskeletal networks to actively segregate the germ plasm from the soma and physically construct the pole buds (PBs) that protrude from the posterior cortex. Of emerging importance is the central role of centrosomes in the coordination of microtubule dynamics and actin organization to promote PGC development. We previously identified a requirement for the centrosome protein Centrosomin (Cnn) in PGC formation. Cnn interacts directly with Pericentrin-like protein (PLP) to form a centrosome scaffold structure required for pericentriolar material recruitment and organization. In this study, we identify a role for PLP at several discrete steps during PGC development. We find PLP functions in segregating the germ plasm from the soma by regulating microtubule organization and centrosome separation. These activities further contribute to promoting PB protrusion and facilitating the distribution of germ plasm in proliferating PGCs." @default.
- W2989748078 created "2019-12-05" @default.
- W2989748078 creator A5029002197 @default.
- W2989748078 creator A5065143503 @default.
- W2989748078 date "2020-03-01" @default.
- W2989748078 modified "2023-09-24" @default.
- W2989748078 title "<i>Drosophila</i>pericentrin‐like protein promotes the formation of primordial germ cells" @default.
- W2989748078 cites W1551482363 @default.
- W2989748078 cites W1781095925 @default.
- W2989748078 cites W1938204331 @default.
- W2989748078 cites W1947138928 @default.
- W2989748078 cites W1969816148 @default.
- W2989748078 cites W1981762151 @default.
- W2989748078 cites W1991245537 @default.
- W2989748078 cites W1991615598 @default.
- W2989748078 cites W2002256260 @default.
- W2989748078 cites W2002666615 @default.
- W2989748078 cites W2004914865 @default.
- W2989748078 cites W2009017737 @default.
- W2989748078 cites W2012999862 @default.
- W2989748078 cites W2014725103 @default.
- W2989748078 cites W2014753175 @default.
- W2989748078 cites W2039513425 @default.
- W2989748078 cites W2039780506 @default.
- W2989748078 cites W2043561363 @default.
- W2989748078 cites W2049264008 @default.
- W2989748078 cites W2054887583 @default.
- W2989748078 cites W2059843465 @default.
- W2989748078 cites W2061237546 @default.
- W2989748078 cites W2062921517 @default.
- W2989748078 cites W2067951423 @default.
- W2989748078 cites W2070020221 @default.
- W2989748078 cites W2073032288 @default.
- W2989748078 cites W2077580699 @default.
- W2989748078 cites W2100713765 @default.
- W2989748078 cites W2100850453 @default.
- W2989748078 cites W2102747560 @default.
- W2989748078 cites W2114458953 @default.
- W2989748078 cites W2120998038 @default.
- W2989748078 cites W2123587496 @default.
- W2989748078 cites W2143720287 @default.
- W2989748078 cites W2145652787 @default.
- W2989748078 cites W2151683388 @default.
- W2989748078 cites W2151854231 @default.
- W2989748078 cites W2153036107 @default.
- W2989748078 cites W2156438992 @default.
- W2989748078 cites W2157448853 @default.
- W2989748078 cites W2158766876 @default.
- W2989748078 cites W2159243681 @default.
- W2989748078 cites W2161287639 @default.
- W2989748078 cites W2167604818 @default.
- W2989748078 cites W2170163976 @default.
- W2989748078 cites W2172088581 @default.
- W2989748078 cites W2187872339 @default.
- W2989748078 cites W2294571251 @default.
- W2989748078 cites W2338064389 @default.
- W2989748078 cites W2582095309 @default.
- W2989748078 cites W2768830475 @default.
- W2989748078 cites W2787376055 @default.
- W2989748078 cites W2790294196 @default.
- W2989748078 cites W28672836 @default.
- W2989748078 cites W59010234 @default.
- W2989748078 doi "https://doi.org/10.1002/dvg.23347" @default.
- W2989748078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8091889" @default.
- W2989748078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31774613" @default.
- W2989748078 hasPublicationYear "2020" @default.
- W2989748078 type Work @default.
- W2989748078 sameAs 2989748078 @default.
- W2989748078 citedByCount "3" @default.
- W2989748078 countsByYear W29897480782022 @default.
- W2989748078 crossrefType "journal-article" @default.
- W2989748078 hasAuthorship W2989748078A5029002197 @default.
- W2989748078 hasAuthorship W2989748078A5065143503 @default.
- W2989748078 hasBestOaLocation W29897480782 @default.
- W2989748078 hasConcept C104317684 @default.
- W2989748078 hasConcept C190446060 @default.
- W2989748078 hasConcept C2776041557 @default.
- W2989748078 hasConcept C2779122487 @default.
- W2989748078 hasConcept C2780258238 @default.
- W2989748078 hasConcept C48221581 @default.
- W2989748078 hasConcept C54355233 @default.
- W2989748078 hasConcept C78458016 @default.
- W2989748078 hasConcept C86803240 @default.
- W2989748078 hasConcept C95444343 @default.
- W2989748078 hasConceptScore W2989748078C104317684 @default.
- W2989748078 hasConceptScore W2989748078C190446060 @default.
- W2989748078 hasConceptScore W2989748078C2776041557 @default.
- W2989748078 hasConceptScore W2989748078C2779122487 @default.
- W2989748078 hasConceptScore W2989748078C2780258238 @default.
- W2989748078 hasConceptScore W2989748078C48221581 @default.
- W2989748078 hasConceptScore W2989748078C54355233 @default.
- W2989748078 hasConceptScore W2989748078C78458016 @default.
- W2989748078 hasConceptScore W2989748078C86803240 @default.
- W2989748078 hasConceptScore W2989748078C95444343 @default.
- W2989748078 hasFunder F4320332161 @default.
- W2989748078 hasIssue "3-4" @default.
- W2989748078 hasLocation W29897480781 @default.
- W2989748078 hasLocation W29897480782 @default.
- W2989748078 hasOpenAccess W2989748078 @default.
- W2989748078 hasPrimaryLocation W29897480781 @default.