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- W2989748872 abstract "Introduction: Traffic-related air pollution exposure is associated with increased cardiovascular morbidity and mortality. The underlying mechanism is unclear, but changes in DNA methylation may mediate the health effects of air pollution. The objective of the present study was to evaluate the association between personal exposure to traffic related air pollution and changes in blood DNA methylation. Methods: Global DNA methylation in whole blood was studied in a population of 55 nurses using HPLC. Personal exposure to black carbon (BC) was measured using portable µ-aethalometers during a participant’s working week. These data were used, in combination with ambient levels measured at a reference site, to derive subchronic BC exposure. Urinary trans,trans-muconic acid (t,t-MA), a metabolite of benzene, was analysed as an additional biomarker for traffic exposure. Results: DNA methylation levels were associated with short and long-term BC exposure. An IQR-increase in BC exposure on lag 24 hours (488 ng/m³), lag 48 hours (494 ng/m³), lag 1 week (313 ng/m³) and subchronic exposure (675 ng/m³) was associated with a decrease in DNA methylation levels of respectively 0.0019% (-0.0038 to -0.0001, p=0.047), 0.0027% (-0.0052 to -0.0003, p=0.036) and 0.0022% (-0.0040 to -0.0005, p=0.017). Consistent with the recent exposure windows, an IQR-increase in subchronic BC exposure (675 ng/m³) was associated with 0.0257% (-0.0491 to -0.0023, p=0.038) lower DNA methylation level. In addition, an IQR-increase in t,t-MA (0,135 mg/l) was associated with a 0.0021% (-0.0033 to -0.0008, p=0.0019) decrease in global DNA methylation levels. Conclusion: We found negative associations between markers of traffic related air pollution exposure and total DNA-methylation in a panel of healthy adults. This adds further evidence to the association between air pollution exposure and DNA-methylation." @default.
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- W2989748872 date "2016-08-17" @default.
- W2989748872 modified "2023-09-23" @default.
- W2989748872 title "Associations between personal traffic exposure indicators and DNA hypomethylation in healthy nurses" @default.
- W2989748872 doi "https://doi.org/10.1289/isee.2016.3539" @default.
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