FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989749654> ?p ?o ?g. }

• W2989749654 endingPage "204201881988882" @default.
• W2989749654 startingPage "204201881988882" @default.
• W2989749654 abstract "Background: Although the health benefits of regular physical activity and exercise are well established and have been incorporated into national public health recommendations, there is a relative lack of understanding pertaining to the harmful effects of physical inactivity. Experimental paradigms including complete immobilization and bed rest are not physiologically representative of sedentary living. A useful ‘real-world’ approach to contextualize the physiology of societal downward shifts in physical activity patterns is that of short-term daily step reduction. Results: Step-reduction studies have largely focused on musculoskeletal and metabolic health parameters, providing relevant disease models for metabolic syndrome, type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD), sarcopenia and osteopenia/osteoporosis. In untrained individuals, even a short-term reduction in physical activity has a significant impact on skeletal muscle protein and carbohydrate metabolism, causing anabolic resistance and peripheral insulin resistance, respectively. From a metabolic perspective, short-term inactivity-induced peripheral insulin resistance in skeletal muscle and adipose tissue, with consequent liver triglyceride accumulation, leads to hepatic insulin resistance and a characteristic dyslipidaemia. Concomitantly, various inactivity-related factors contribute to a decline in function; a reduction in cardiorespiratory fitness, muscle mass and muscle strength. Conclusions: Physical inactivity maybe particularly deleterious in certain patient populations, such as those at high risk of T2D or in the elderly, considering concomitant sarcopenia or osteoporosis. The effects of short-term physical inactivity (with step reduction) are reversible on resumption of habitual physical activity in younger people, but less so in older adults. Nutritional interventions and resistance training offer potential strategies to prevent these deleterious metabolic and musculoskeletal effects. Impact: Individuals at high risk of/with cardiometabolic disease and older adults may be more prone to these acute periods of inactivity due to acute illness or hospitalization. Understanding the risks is paramount to implementing countermeasures." @default.
• W2989749654 created "2019-12-05" @default.
• W2989749654 creator A5021599391 @default.
• W2989749654 creator A5029356357 @default.
• W2989749654 creator A5030063448 @default.
• W2989749654 creator A5039022114 @default.
• W2989749654 creator A5068272755 @default.
• W2989749654 creator A5075760256 @default.
• W2989749654 creator A5078113496 @default.
• W2989749654 creator A5082908640 @default.
• W2989749654 date "2019-01-01" @default.
• W2989749654 modified "2023-10-14" @default.
• W2989749654 title "Reduced physical activity in young and older adults: metabolic and musculoskeletal implications" @default.
• W2989749654 cites W1547422201 @default.
• W2989749654 cites W1548759563 @default.
• W2989749654 cites W1781750677 @default.
• W2989749654 cites W1942492953 @default.
• W2989749654 cites W1945984274 @default.
• W2989749654 cites W1964107990 @default.
• W2989749654 cites W1966218079 @default.
• W2989749654 cites W1970653898 @default.
• W2989749654 cites W1972643702 @default.
• W2989749654 cites W1982111510 @default.
• W2989749654 cites W1984535102 @default.
• W2989749654 cites W1986050121 @default.
• W2989749654 cites W1997279776 @default.
• W2989749654 cites W1997591046 @default.
• W2989749654 cites W2001441616 @default.
• W2989749654 cites W2003301619 @default.
• W2989749654 cites W2010275895 @default.
• W2989749654 cites W2016420804 @default.
• W2989749654 cites W2016921793 @default.
• W2989749654 cites W2019627189 @default.
• W2989749654 cites W2033504603 @default.
• W2989749654 cites W2037048755 @default.
• W2989749654 cites W2039735127 @default.
• W2989749654 cites W2051446390 @default.
• W2989749654 cites W2052619923 @default.
• W2989749654 cites W2072752134 @default.
• W2989749654 cites W2094762031 @default.
• W2989749654 cites W2096528587 @default.
• W2989749654 cites W2097019206 @default.
• W2989749654 cites W2102902846 @default.
• W2989749654 cites W2104357394 @default.
• W2989749654 cites W2104770587 @default.
• W2989749654 cites W2107358551 @default.
• W2989749654 cites W2108674713 @default.
• W2989749654 cites W2109691994 @default.
• W2989749654 cites W2110943180 @default.
• W2989749654 cites W2111862777 @default.
• W2989749654 cites W2112186681 @default.
• W2989749654 cites W2119448420 @default.
• W2989749654 cites W2122806520 @default.
• W2989749654 cites W2128621051 @default.
• W2989749654 cites W2130819432 @default.
• W2989749654 cites W2136285007 @default.
• W2989749654 cites W2143745192 @default.
• W2989749654 cites W2145763683 @default.
• W2989749654 cites W2146281387 @default.
• W2989749654 cites W2150766174 @default.
• W2989749654 cites W2157064067 @default.
• W2989749654 cites W2159234192 @default.
• W2989749654 cites W2159262419 @default.
• W2989749654 cites W2162441719 @default.
• W2989749654 cites W2164613013 @default.
• W2989749654 cites W2167756436 @default.
• W2989749654 cites W2170627826 @default.
• W2989749654 cites W2170869159 @default.
• W2989749654 cites W2180695096 @default.
• W2989749654 cites W2233453157 @default.
• W2989749654 cites W2478127453 @default.
• W2989749654 cites W2493586185 @default.
• W2989749654 cites W2496365719 @default.
• W2989749654 cites W2507609521 @default.
• W2989749654 cites W2551962319 @default.
• W2989749654 cites W2588601551 @default.
• W2989749654 cites W2591962037 @default.
• W2989749654 cites W2612886500 @default.
• W2989749654 cites W2618096841 @default.
• W2989749654 cites W2726248338 @default.
• W2989749654 cites W2733535447 @default.
• W2989749654 cites W2734380231 @default.
• W2989749654 cites W2746103056 @default.
• W2989749654 cites W2765584992 @default.
• W2989749654 cites W2770065569 @default.
• W2989749654 cites W2791274003 @default.
• W2989749654 cites W2802469991 @default.
• W2989749654 cites W2804799855 @default.
• W2989749654 cites W2885711716 @default.
• W2989749654 cites W2890433318 @default.
• W2989749654 cites W4243230640 @default.
• W2989749654 cites W4247067097 @default.
• W2989749654 cites W4320300836 @default.
• W2989749654 doi "https://doi.org/10.1177/2042018819888824" @default.
• W2989749654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6878603" @default.
• W2989749654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31803464" @default.
• W2989749654 hasPublicationYear "2019" @default.
• W2989749654 type Work @default.

• next