Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989752021> ?p ?o ?g. }
- W2989752021 endingPage "6056" @default.
- W2989752021 startingPage "6056" @default.
- W2989752021 abstract "Nanoparticles are becoming an increasingly popular tool for biomedical imaging and drug delivery. While the prevalence of nanoparticle drug-delivery systems reported in the literature increases yearly, relatively little translation from the bench to the bedside has occurred. It is crucial for the scientific community to recognize this shortcoming and re-evaluate standard practices in the field, to increase clinical translatability. Currently, nanoparticle drug-delivery systems are designed to increase circulation, target disease states, enhance retention in diseased tissues, and provide targeted payload release. To manage these demands, the surface of the particle is often modified with a variety of chemical and biological moieties, including PEG, tumor targeting peptides, and environmentally responsive linkers. Regardless of the surface modifications, the nano–bio interface, which is mediated by opsonization and the protein corona, often remains problematic. While fabrication and assessment techniques for nanoparticles have seen continued advances, a thorough evaluation of the particle’s interaction with the immune system has lagged behind, seemingly taking a backseat to particle characterization. This review explores current limitations in the evaluation of surface-modified nanoparticle biocompatibility and in vivo model selection, suggesting a promising standardized pathway to clinical translation." @default.
- W2989752021 created "2019-12-05" @default.
- W2989752021 creator A5034492177 @default.
- W2989752021 creator A5038664061 @default.
- W2989752021 creator A5043071888 @default.
- W2989752021 creator A5044523133 @default.
- W2989752021 creator A5085575818 @default.
- W2989752021 date "2019-11-30" @default.
- W2989752021 modified "2023-10-06" @default.
- W2989752021 title "Overcoming Hurdles in Nanoparticle Clinical Translation: The Influence of Experimental Design and Surface Modification" @default.
- W2989752021 cites W1512179335 @default.
- W2989752021 cites W1564553363 @default.
- W2989752021 cites W1587071366 @default.
- W2989752021 cites W1595072120 @default.
- W2989752021 cites W1635521333 @default.
- W2989752021 cites W1843302206 @default.
- W2989752021 cites W1964023538 @default.
- W2989752021 cites W1965097716 @default.
- W2989752021 cites W1967434989 @default.
- W2989752021 cites W1968492694 @default.
- W2989752021 cites W1974526584 @default.
- W2989752021 cites W1974854923 @default.
- W2989752021 cites W1974941970 @default.
- W2989752021 cites W1975890825 @default.
- W2989752021 cites W1976041621 @default.
- W2989752021 cites W1985659403 @default.
- W2989752021 cites W1986245427 @default.
- W2989752021 cites W1988197319 @default.
- W2989752021 cites W1997264941 @default.
- W2989752021 cites W1999880807 @default.
- W2989752021 cites W2001983171 @default.
- W2989752021 cites W2002015794 @default.
- W2989752021 cites W2003276331 @default.
- W2989752021 cites W2007307087 @default.
- W2989752021 cites W2009805582 @default.
- W2989752021 cites W2021084752 @default.
- W2989752021 cites W2021876818 @default.
- W2989752021 cites W2023863818 @default.
- W2989752021 cites W2024461025 @default.
- W2989752021 cites W2033803049 @default.
- W2989752021 cites W2037048276 @default.
- W2989752021 cites W2037432819 @default.
- W2989752021 cites W2037534124 @default.
- W2989752021 cites W2039201937 @default.
- W2989752021 cites W2041780927 @default.
- W2989752021 cites W2048104401 @default.
- W2989752021 cites W2048348500 @default.
- W2989752021 cites W2050622829 @default.
- W2989752021 cites W2053311966 @default.
- W2989752021 cites W2054847598 @default.
- W2989752021 cites W2054981131 @default.
- W2989752021 cites W2054992180 @default.
- W2989752021 cites W2057910069 @default.
- W2989752021 cites W2061501822 @default.
- W2989752021 cites W2066155460 @default.
- W2989752021 cites W2067488225 @default.
- W2989752021 cites W2071697696 @default.
- W2989752021 cites W2072164275 @default.
- W2989752021 cites W2077607728 @default.
- W2989752021 cites W2078725345 @default.
- W2989752021 cites W2082990150 @default.
- W2989752021 cites W2085178300 @default.
- W2989752021 cites W2086856055 @default.
- W2989752021 cites W2088547883 @default.
- W2989752021 cites W2091247188 @default.
- W2989752021 cites W2091394849 @default.
- W2989752021 cites W2096828550 @default.
- W2989752021 cites W2098565706 @default.
- W2989752021 cites W2099445482 @default.
- W2989752021 cites W2099692303 @default.
- W2989752021 cites W2100090013 @default.
- W2989752021 cites W2108615682 @default.
- W2989752021 cites W2120579564 @default.
- W2989752021 cites W2121052722 @default.
- W2989752021 cites W2123624166 @default.
- W2989752021 cites W2124409897 @default.
- W2989752021 cites W2124720032 @default.
- W2989752021 cites W2127876468 @default.
- W2989752021 cites W2135595096 @default.
- W2989752021 cites W2141778888 @default.
- W2989752021 cites W2143540084 @default.
- W2989752021 cites W2145736500 @default.
- W2989752021 cites W2150146274 @default.
- W2989752021 cites W2155109953 @default.
- W2989752021 cites W2156069838 @default.
- W2989752021 cites W2156750162 @default.
- W2989752021 cites W2157963288 @default.
- W2989752021 cites W2162750459 @default.
- W2989752021 cites W2164520862 @default.
- W2989752021 cites W2165546510 @default.
- W2989752021 cites W2170248971 @default.
- W2989752021 cites W2186540256 @default.
- W2989752021 cites W2191780303 @default.
- W2989752021 cites W2192049920 @default.
- W2989752021 cites W2194502287 @default.
- W2989752021 cites W2221782503 @default.
- W2989752021 cites W2230383031 @default.
- W2989752021 cites W2255868746 @default.