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W2989755107 abstract "Infections induce complex host responses linked to antiviral defense, inflammation, and tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may orchestrate systemic metabolic changes during infection. We infected mice with chronic lymphocytic choriomeningitis virus (LCMV), performed RNA sequencing and proteomics of liver tissue, and integrated these data with serum metabolomics at different infection phases. Widespread reprogramming of liver metabolism occurred early after infection, correlating with type I interferon (IFN-I) responses. Viral infection induced metabolic alterations of the liver that depended on the interferon alpha/beta receptor (IFNAR1). Hepatocyte-intrinsic IFNAR1 repressed the transcription of metabolic genes, including Otc and Ass1, which encode urea cycle enzymes. This led to decreased arginine and increased ornithine concentrations in the circulation, resulting in suppressed virus-specific CD8+ T cell responses and ameliorated liver pathology. These findings establish IFN-I-induced modulation of hepatic metabolism and the urea cycle as an endogenous mechanism of immunoregulation.Video AbstracteyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiI1MDczMGJjOTFkMDQ0MzFkY2Y1ZWUyMzRkMjg2ZTQ1NiIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjk1MzQ4NjgzfQ.CYX3oxhv-3rm7FeH-wpF4_XHQdaAg3kgOXSPE11kzvHYLXDf1gb6UWYJ_o6j_1cI2gS3IvhLMGCYUmZct6aL6IwQ5MvqN71RP0UMnEYygd8KtTepLXR9cR_sVv5e7G4LTzu_GG49pQzEFGtfLE2dHwtW9CDUgauXOJWcznWtinnQrqkRvQp9e_Ra7x_IXVrXmbR-u4pdhpJ9mjzGSPvJLy-nSxMQ0girL5INcNiZdnuQ2wZKRLC4QHfHrAx_7PWTu9c_4WygWx0dwB89jatCQm1I2DyUWoM8bJ6BX2rq0IfCo19n2QrP3F-QRcMTT7CIKAUUjn9c9C5dxajY7YRKWQ(mp4, (17.82 MB) Download video" @default.
W2989755107 created "2019-12-05" @default.
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W2989755107 date "2019-12-01" @default.
W2989755107 modified "2023-10-17" @default.
W2989755107 title "Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function" @default.
W2989755107 cites W1226282535 @default.
W2989755107 cites W1822758711 @default.
W2989755107 cites W1828418245 @default.
W2989755107 cites W1848248203 @default.
W2989755107 cites W1910012553 @default.
W2989755107 cites W1957522192 @default.
W2989755107 cites W1966815294 @default.
W2989755107 cites W1970785321 @default.
W2989755107 cites W1975350694 @default.
W2989755107 cites W1976269285 @default.
W2989755107 cites W1977728069 @default.
W2989755107 cites W1992444724 @default.
W2989755107 cites W1993023349 @default.
W2989755107 cites W1996235861 @default.
W2989755107 cites W1997958695 @default.
W2989755107 cites W1999324987 @default.
W2989755107 cites W2004829503 @default.
W2989755107 cites W2009519656 @default.
W2989755107 cites W2012034410 @default.
W2989755107 cites W2016281184 @default.
W2989755107 cites W2029180341 @default.
W2989755107 cites W2031084334 @default.
W2989755107 cites W2033556277 @default.
W2989755107 cites W2037199116 @default.
W2989755107 cites W2037555606 @default.
W2989755107 cites W2047882003 @default.
W2989755107 cites W2051433308 @default.
W2989755107 cites W2053330602 @default.
W2989755107 cites W2055376061 @default.
W2989755107 cites W2057707223 @default.
W2989755107 cites W2060691337 @default.
W2989755107 cites W2066858504 @default.
W2989755107 cites W2071267501 @default.
W2989755107 cites W2076272449 @default.
W2989755107 cites W2078646756 @default.
W2989755107 cites W2080582253 @default.
W2989755107 cites W2081098333 @default.
W2989755107 cites W2087285715 @default.
W2989755107 cites W2091129202 @default.
W2989755107 cites W2099468505 @default.
W2989755107 cites W2100039832 @default.
W2989755107 cites W2102921180 @default.
W2989755107 cites W2108462008 @default.
W2989755107 cites W2110438479 @default.
W2989755107 cites W2120049814 @default.
W2989755107 cites W2123559384 @default.
W2989755107 cites W2126795224 @default.
W2989755107 cites W2129920232 @default.
W2989755107 cites W2134749398 @default.
W2989755107 cites W2137526110 @default.
W2989755107 cites W2138207763 @default.
W2989755107 cites W2158804744 @default.
W2989755107 cites W2169589032 @default.
W2989755107 cites W2171729436 @default.
W2989755107 cites W2179216099 @default.
W2989755107 cites W2191790139 @default.
W2989755107 cites W2205019274 @default.
W2989755107 cites W2206617731 @default.
W2989755107 cites W2212795645 @default.
W2989755107 cites W2259139274 @default.
W2989755107 cites W2412278817 @default.
W2989755107 cites W2468283555 @default.
W2989755107 cites W2472071085 @default.
W2989755107 cites W2511526235 @default.
W2989755107 cites W2530067632 @default.