Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989763013> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2989763013 endingPage "1395" @default.
- W2989763013 startingPage "1389" @default.
- W2989763013 abstract "To detect the molecular cytogenetic abnormalities of multiple myeloma (MM) by using microrray-based comparative genomic hybridization (array-CGH) technology and to investigate its value of application in MM.The whole-genoine copy number variants (CNV) of bone marrow samples acquired from 20 cases of newly diagnosed MM patients were detected by genome-wide hybridization and scanning by CytoScan 750K Array (Affymetrix). At the same time, the chromosome abnormalities of bone marrow cells were detected by karyotype analysis and FISH using 9 specific probes: D13S319, RB1, p53, 1q21, IgH, IgH/CCND1, IgH/FGFR3, IgH/MAF, IgH/MAFB.Among the 20 MM patients, the incidence of chromosome abnormalities detected by karyotype analysis, FISH and array-CGH were 15%, 65% and 90%, respectively. The types of CNV detected by array-CGH included the gain (106), loss (156) or UPD (23). There were many different CNVs in every chromosomes except chromosome 5, 9, 18, 21 and Y. Comparison of chromosome abnormalities detected by FISH and array-CGH showed that, the positive ratio of del (13q) was 35% and 40% respectively; the positive ratio of amp (1q) was 40% and 50% respectively; the positive ratio of del (17p) was both 15%. FISH detection showed 8 cases with IgH rearrangement, meansahile the array-CGH detection showed that 4 cases had amp (11q13) (CCND1 gene), 3 cases had amp (16q23) (MAF gene), 1 case had amp (4p16) (FGFR3 gene) and 2 cases had amp (20q12) (MAFB gene). Besides, many other new chromosome abnormalities were found.More than half of MM patients have cytogenetic changes, and most of them are complex chromosomal abnormalities. By using array-CGH, more chromosome abnormalities can be detected and more cytogenetic information can be provided for clinician." @default.
- W2989763013 created "2019-12-05" @default.
- W2989763013 creator A5002990257 @default.
- W2989763013 creator A5022565445 @default.
- W2989763013 creator A5027220663 @default.
- W2989763013 creator A5033822228 @default.
- W2989763013 creator A5037677450 @default.
- W2989763013 creator A5053725057 @default.
- W2989763013 creator A5056530877 @default.
- W2989763013 date "2018-10-01" @default.
- W2989763013 modified "2023-10-17" @default.
- W2989763013 title "[Detection of the Cytogenetic Aberrations in Multiple Myeloma by Using Microrray Comparative Genomic Hybridization]." @default.
- W2989763013 doi "https://doi.org/10.7534/j.issn.1009-2137.2018.05.022" @default.
- W2989763013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30295256" @default.
- W2989763013 hasPublicationYear "2018" @default.
- W2989763013 type Work @default.
- W2989763013 sameAs 2989763013 @default.
- W2989763013 citedByCount "0" @default.
- W2989763013 crossrefType "journal-article" @default.
- W2989763013 hasAuthorship W2989763013A5002990257 @default.
- W2989763013 hasAuthorship W2989763013A5022565445 @default.
- W2989763013 hasAuthorship W2989763013A5027220663 @default.
- W2989763013 hasAuthorship W2989763013A5033822228 @default.
- W2989763013 hasAuthorship W2989763013A5037677450 @default.
- W2989763013 hasAuthorship W2989763013A5053725057 @default.
- W2989763013 hasAuthorship W2989763013A5056530877 @default.
- W2989763013 hasConcept C104317684 @default.
- W2989763013 hasConcept C120821319 @default.
- W2989763013 hasConcept C124942203 @default.
- W2989763013 hasConcept C141231307 @default.
- W2989763013 hasConcept C153911025 @default.
- W2989763013 hasConcept C167752854 @default.
- W2989763013 hasConcept C2777542201 @default.
- W2989763013 hasConcept C2780907584 @default.
- W2989763013 hasConcept C30481170 @default.
- W2989763013 hasConcept C53226629 @default.
- W2989763013 hasConcept C54355233 @default.
- W2989763013 hasConcept C7602840 @default.
- W2989763013 hasConcept C86803240 @default.
- W2989763013 hasConceptScore W2989763013C104317684 @default.
- W2989763013 hasConceptScore W2989763013C120821319 @default.
- W2989763013 hasConceptScore W2989763013C124942203 @default.
- W2989763013 hasConceptScore W2989763013C141231307 @default.
- W2989763013 hasConceptScore W2989763013C153911025 @default.
- W2989763013 hasConceptScore W2989763013C167752854 @default.
- W2989763013 hasConceptScore W2989763013C2777542201 @default.
- W2989763013 hasConceptScore W2989763013C2780907584 @default.
- W2989763013 hasConceptScore W2989763013C30481170 @default.
- W2989763013 hasConceptScore W2989763013C53226629 @default.
- W2989763013 hasConceptScore W2989763013C54355233 @default.
- W2989763013 hasConceptScore W2989763013C7602840 @default.
- W2989763013 hasConceptScore W2989763013C86803240 @default.
- W2989763013 hasIssue "5" @default.
- W2989763013 hasLocation W29897630131 @default.
- W2989763013 hasOpenAccess W2989763013 @default.
- W2989763013 hasPrimaryLocation W29897630131 @default.
- W2989763013 hasRelatedWork W1984312550 @default.
- W2989763013 hasRelatedWork W2078653071 @default.
- W2989763013 hasRelatedWork W2095333479 @default.
- W2989763013 hasRelatedWork W2136211437 @default.
- W2989763013 hasRelatedWork W2172269228 @default.
- W2989763013 hasRelatedWork W2510650860 @default.
- W2989763013 hasRelatedWork W2757414886 @default.
- W2989763013 hasRelatedWork W2989763013 @default.
- W2989763013 hasRelatedWork W3163172335 @default.
- W2989763013 hasRelatedWork W3217003529 @default.
- W2989763013 hasVolume "26" @default.
- W2989763013 isParatext "false" @default.
- W2989763013 isRetracted "false" @default.
- W2989763013 magId "2989763013" @default.
- W2989763013 workType "article" @default.