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- W2989771072 abstract "In The Lancet Oncology, Robert Coleman and colleagues 1 Coleman R Finkelstein DM Barrios C et al. Adjuvant denosumab in early breast cancer (D-CARE): an international, multicentre, randomised, controlled, phase 3 trial. Lancet Oncol. 2019; (published online Dec 2)https://doi.org/10.1016/S1470-2045(19)30687-4 Summary Full Text Full Text PDF Scopus (104) Google Scholar report that the addition to adjuvant therapy of an intensive treatment with denosumab (120 mg subcutaneously every 3–4 weeks and then every 12 weeks for 5 years) in the D-CARE trial does not improve clinically significant outcomes of patients with early breast cancer. Moreover, 122 (5%) of the 2241 patients receiving denosumab had osteonecrosis of the jaw, which had not resolved by data cutoff in more than half of the cases. Adjuvant denosumab in early breast cancer (D-CARE): an international, multicentre, randomised, controlled, phase 3 trialDespite preclinical evidence suggesting RANKL inhibition might delay bone metastasis or disease recurrence in patients with early-stage breast cancer, in this study, denosumab did not improve disease-related outcomes for women with high-risk early breast cancer. Full-Text PDF" @default.
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- W2989771072 date "2020-01-01" @default.
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- W2989771072 title "Denosumab in early breast cancer: negative data and a call to action" @default.
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- W2989771072 doi "https://doi.org/10.1016/s1470-2045(19)30717-x" @default.
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