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• W2989772754 abstract "Abstract Psychostimulants such as methylphenidate (MPD) have long been the treatment of choice in behavioral disorders such as attention deficit/hyperactivity disorder (ADHD) and narcolepsy in both children and adults. However, its abuse by healthy children and adults for academic enhancement or recreation is on the rise. This raises concern for brain chemistry alteration leading to dependence during a period of neuroplasticity and brain development. Psychostimulants such as MPD are indirect dopamine antagonists and are known to act on the dopaminergic system of the brain to produce their effects. The ventral tegmental area (VTA) is one of the primary sources of dopamine in the CNS and is a part of the reward circuits affected by MPD. In order to elucidate the role of the VTA in MPD exposure, five groups of rats were used: VTA intact control, sham VTA surgery, nonspecific electrolytic VTA lesion, glutamatergic specific VTA chemical lesion, and dopaminergic specific VTA chemical lesion. Baseline locomotor activity was established, then the surgeries were performed followed by several days of recovery and establishment of post-surgical baseline. Following the recovery period, the rats were challenged with 6 days of MPD exposure, followed by 3 washout days, then a re-challenge of MPD to assess chronic MPD exposure on animals behavior. Locomotive activity was recorded for 120 min after each injection by a computerized animal activity monitor system. The results indicate that glutamatergic synapses in the ventral tegmental area are critical for acute and chronic MPD response, while dopaminergic synapses contribute to tonic inhibition of the ventral tegmental area on rat locomotor excitation." @default.
• W2989772754 created "2019-12-05" @default.
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• W2989772754 date "2020-02-01" @default.
• W2989772754 modified "2023-10-14" @default.
• W2989772754 title "Glutamate and dopamine in the VTA participate differently in the acute and chronic effect of methylphenidate" @default.
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• W2989772754 cites W1901626591 @default.
• W2989772754 cites W1902584234 @default.
• W2989772754 cites W1927865998 @default.
• W2989772754 cites W1967443835 @default.
• W2989772754 cites W1969761142 @default.
• W2989772754 cites W1977925866 @default.
• W2989772754 cites W1981961774 @default.
• W2989772754 cites W1988746979 @default.
• W2989772754 cites W1989058665 @default.
• W2989772754 cites W1993121339 @default.
• W2989772754 cites W1997128521 @default.
• W2989772754 cites W1998893768 @default.
• W2989772754 cites W2003367821 @default.
• W2989772754 cites W2004425853 @default.
• W2989772754 cites W2005307259 @default.
• W2989772754 cites W2007756992 @default.
• W2989772754 cites W2008388130 @default.
• W2989772754 cites W2009243814 @default.
• W2989772754 cites W2010196974 @default.
• W2989772754 cites W2016258499 @default.
• W2989772754 cites W2016929635 @default.
• W2989772754 cites W2017814888 @default.
• W2989772754 cites W2018489032 @default.
• W2989772754 cites W2020209931 @default.
• W2989772754 cites W2022406556 @default.
• W2989772754 cites W2026106216 @default.
• W2989772754 cites W2028424000 @default.
• W2989772754 cites W2029879219 @default.
• W2989772754 cites W2030288942 @default.
• W2989772754 cites W2030483725 @default.
• W2989772754 cites W2031361314 @default.
• W2989772754 cites W2032829414 @default.
• W2989772754 cites W2033908258 @default.
• W2989772754 cites W2036572502 @default.
• W2989772754 cites W2037430625 @default.
• W2989772754 cites W2043509245 @default.
• W2989772754 cites W2043630892 @default.
• W2989772754 cites W2044400361 @default.
• W2989772754 cites W2044584560 @default.
• W2989772754 cites W2045873213 @default.
• W2989772754 cites W2053209336 @default.
• W2989772754 cites W2061161259 @default.
• W2989772754 cites W2065048782 @default.
• W2989772754 cites W2068319999 @default.
• W2989772754 cites W2068634948 @default.
• W2989772754 cites W2068949066 @default.
• W2989772754 cites W2072355718 @default.
• W2989772754 cites W2077153133 @default.
• W2989772754 cites W2080040700 @default.
• W2989772754 cites W2087073843 @default.
• W2989772754 cites W2092792131 @default.
• W2989772754 cites W2098677721 @default.
• W2989772754 cites W2100300432 @default.
• W2989772754 cites W2104492171 @default.
• W2989772754 cites W2126502833 @default.
• W2989772754 cites W2137480418 @default.
• W2989772754 cites W2140513029 @default.
• W2989772754 cites W2140986639 @default.
• W2989772754 cites W2151158926 @default.
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• W2989772754 cites W2165398609 @default.
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• W2989772754 cites W2509099448 @default.
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• W2989772754 doi "https://doi.org/10.1016/j.bbr.2019.112390" @default.
• W2989772754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31783089" @default.
• W2989772754 hasPublicationYear "2020" @default.
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