FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989772907> ?p ?o ?g. }

• W2989772907 abstract "Abstract Background As a new generation antihistamine, fexofenadine has been widely used in allergic diseases. However, there is still a lack of collective evidence regarding the antihistamine effects and safety profiles of fexofenadine relative to other antihistamine drugs and placebo. Therefore, we aimed to systematically evaluate the antihistamine effects and safety of fexofenadine. Methods An electronic literature search of randomized controlled trials (RCTs) was performed using Embase, Cochrane and PubMed from establishment to January 1st, 2018. RCTs comparing the antihistamine effects or safety (adverse events, sedative effects, and cognitive/psychomotor function) of fexofenadine with either other antihistamines or placebo for healthy subjects and patients with allergy were selected. Results Fifty-one studies of 14,551 participants met the inclusion criteria. When compared with the first-generation antihistamines, fexofenadine produced significantly lower adverse events frequency (OR = 0.446; 95% CI: 0.214 to 0.929, P = 0.031), significantly lower sedative effects frequency (OR = 0.265; 95% CI: 0.072 to 0.976, P = 0.046) and significantly less change of all cognitive/psychomotor function. When compared with the second-generation antihistamines, fexofenadine produced significantly marginal sedative effects (OR = 0.59; 95% CI, 0.38 to 0.93; P = 0.02) and significantly less change of most of the cognitive/psychomotor function. When compared with placebo, fexofenadine produced more significant antihistamine effects. Conclusions Fexofenadine has a positive antihistamine effect, which is probably no worse than the second-generation antihistamines. Fexofenadine probably has a favorable safety profile, which is more likely better than that of the first-generation antihistamines. There is lack of data to support that fexofenadine has a better overall safety profile compared to the second-generation antihistamines, however, some presently available evidence on sedative effects and certain aspects of cognitive/psychomotor function favors fexofenadine. Therefore, fexofenadine may be worthy of recommendation for safety related workers." @default.
• W2989772907 created "2019-12-05" @default.
• W2989772907 creator A5009162241 @default.
• W2989772907 creator A5027700820 @default.
• W2989772907 creator A5032764121 @default.
• W2989772907 creator A5066475814 @default.
• W2989772907 creator A5081853924 @default.
• W2989772907 date "2019-11-29" @default.
• W2989772907 modified "2023-10-12" @default.
• W2989772907 title "Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials" @default.
• W2989772907 cites W1543495754 @default.
• W2989772907 cites W1756057165 @default.
• W2989772907 cites W1965069012 @default.
• W2989772907 cites W1966084126 @default.
• W2989772907 cites W1973319846 @default.
• W2989772907 cites W1979041028 @default.
• W2989772907 cites W1982934756 @default.
• W2989772907 cites W1986003773 @default.
• W2989772907 cites W1989926090 @default.
• W2989772907 cites W1991717275 @default.
• W2989772907 cites W1991790975 @default.
• W2989772907 cites W1994282327 @default.
• W2989772907 cites W1999304975 @default.
• W2989772907 cites W2000540088 @default.
• W2989772907 cites W2002385669 @default.
• W2989772907 cites W2012726898 @default.
• W2989772907 cites W2016121352 @default.
• W2989772907 cites W2017009033 @default.
• W2989772907 cites W2019704109 @default.
• W2989772907 cites W2019773157 @default.
• W2989772907 cites W2020530037 @default.
• W2989772907 cites W2023098682 @default.
• W2989772907 cites W2026571068 @default.
• W2989772907 cites W2027284238 @default.
• W2989772907 cites W2027406088 @default.
• W2989772907 cites W2033211028 @default.
• W2989772907 cites W2038121739 @default.
• W2989772907 cites W2046142879 @default.
• W2989772907 cites W2052990038 @default.
• W2989772907 cites W2055269921 @default.
• W2989772907 cites W2056758560 @default.
• W2989772907 cites W2059012840 @default.
• W2989772907 cites W2061606272 @default.
• W2989772907 cites W2061914765 @default.
• W2989772907 cites W2066568226 @default.
• W2989772907 cites W2067382075 @default.
• W2989772907 cites W2068712706 @default.
• W2989772907 cites W2068944194 @default.
• W2989772907 cites W2072632092 @default.
• W2989772907 cites W2072883273 @default.
• W2989772907 cites W2073344491 @default.
• W2989772907 cites W2073532278 @default.
• W2989772907 cites W2074283024 @default.
• W2989772907 cites W2076285395 @default.
• W2989772907 cites W2077730619 @default.
• W2989772907 cites W2078245179 @default.
• W2989772907 cites W2080400600 @default.
• W2989772907 cites W2082654836 @default.
• W2989772907 cites W2084543758 @default.
• W2989772907 cites W2085368717 @default.
• W2989772907 cites W2085628760 @default.
• W2989772907 cites W2086234584 @default.
• W2989772907 cites W2088674100 @default.
• W2989772907 cites W2089002145 @default.
• W2989772907 cites W2090954462 @default.
• W2989772907 cites W2093524798 @default.
• W2989772907 cites W2112385269 @default.
• W2989772907 cites W2130655756 @default.
• W2989772907 cites W2150391039 @default.
• W2989772907 cites W2158730279 @default.
• W2989772907 cites W2202685985 @default.
• W2989772907 cites W2326687065 @default.
• W2989772907 cites W2404083493 @default.
• W2989772907 cites W2464096655 @default.
• W2989772907 cites W2500404775 @default.
• W2989772907 cites W2569502064 @default.
• W2989772907 cites W2587837503 @default.
• W2989772907 cites W2792284976 @default.
• W2989772907 cites W3027688385 @default.
• W2989772907 cites W603342527 @default.
• W2989772907 cites W2394677085 @default.
• W2989772907 doi "https://doi.org/10.1186/s40360-019-0363-1" @default.
• W2989772907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6884918" @default.
• W2989772907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31783781" @default.
• W2989772907 hasPublicationYear "2019" @default.
• W2989772907 type Work @default.
• W2989772907 sameAs 2989772907 @default.
• W2989772907 citedByCount "16" @default.
• W2989772907 countsByYear W29897729072020 @default.
• W2989772907 countsByYear W29897729072021 @default.
• W2989772907 countsByYear W29897729072022 @default.
• W2989772907 countsByYear W29897729072023 @default.
• W2989772907 crossrefType "journal-article" @default.
• W2989772907 hasAuthorship W2989772907A5009162241 @default.
• W2989772907 hasAuthorship W2989772907A5027700820 @default.
• W2989772907 hasAuthorship W2989772907A5032764121 @default.
• W2989772907 hasAuthorship W2989772907A5066475814 @default.
• W2989772907 hasAuthorship W2989772907A5081853924 @default.
• W2989772907 hasBestOaLocation W29897729071 @default.
• W2989772907 hasConcept C126322002 @default.

• next