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- W2989773559 abstract "Background: Non-invasive ventilation (NIV) is a standard therapy for patients with chronic respiratory insufficiency and it has been shown that there is a reduction of dyspnoea for patients with severe COPD under the application of inspiratory airway pressure under load. It has been shown that NIV reduces dyspnoea and extends the walking distance. However, the applicability in the clinical routine is limited and could not be established so far. For this reason a portable NIV device could be able to improve endurance capacity of patients with severe COPD. Methods: This trial will investigate the effect of a mobile BiPAP device on dyspnoea, endurance capacity, blood gases and walking distance. During a six-minute-walking trial (6MWT) with and without the VitaBreath device 23 COPD patients were randomised in a cross-over setting. The primary endpoint was the average difference of the Borg dyspnoea scale before and after a 6MWT. Results: Mean dyspnoea scale difference was 4.4(IQR 6-8) without using mobile device to 4.5(IQR 6-7) using mobile device. The analysis showed no statistical significant difference of dyspnoea reduction (p=0.548). The walking distance decreased from 291.5m(CI 246.1-336.9) to 258.4m(CI 213.0-303.8) when walking with VitaBreath. Additionally, the arterial oxygen tension was significantly lower when using the device during 6MWT 56.5mmHg(CI 52.6-60.4) to 60.1mmHg(CI 56.2-64.1) without. Conclusion: The results don’t show a dyspnoea reduction under load by using the device in patients with respiratory insufficiency already using NIV. It remains unclear if less severe COPD patients might benefit." @default.
- W2989773559 created "2019-12-05" @default.
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- W2989773559 date "2019-09-28" @default.
- W2989773559 modified "2023-09-27" @default.
- W2989773559 title "Is the usage of a mobile BiPAP device capable of reducing dyspnoea during exercise in patients with severe COPD and respiratory insufficiency?- a randomized controlled trial -" @default.
- W2989773559 doi "https://doi.org/10.1183/13993003.congress-2019.pa4046" @default.
- W2989773559 hasPublicationYear "2019" @default.
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