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- W2989774092 abstract "Background: Few studies have examined the natural history of asthma exacerbations in an ageing population, most have focused on younger patients or severe patient cohorts. Methods: Subjects with doctors diagnosed asthma in the Rotterdam Study, a population-based cohort from January 1991 to May 2018 were assessed for asthma exacerbations. Participants were aged 45 years or above. Characteristics of exacerbators versus non-exacerbators were depicted. Exacerbation risk factors were appraised using time dependent cox-regression. Results: Mean follow-up time was 13.87 years. Out of 763 participants with asthma did 427(56.0%) experience at least one exacerbation. Mean exacerbation rate in the entire cohort was 0.22. We demonstrate seasonality in the exacerbation distribution pattern, independent of eosinophil status. Median exacerbation free survival time was 9.8 years. Risk factors for exacerbations entailed prior exacerbation, age, use of respiratory medication, spirometry, respiratory complaints and smoking status. Conclusion: Within a population based cohort of middle-aged and older asthmatics with long term follow-up not all suffer exacerbations. Impaired lung function, persistent smoking, history of exacerbations and respiratory complaints are associated with an increase in exacerbation rates." @default.
- W2989774092 created "2019-12-05" @default.
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- W2989774092 date "2019-09-28" @default.
- W2989774092 modified "2023-09-23" @default.
- W2989774092 title "Asthma exacerbation patterns in middle-aged and older adults; the Rotterdam Study" @default.
- W2989774092 doi "https://doi.org/10.1183/13993003.congress-2019.pa5070" @default.
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