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- W2989776685 endingPage "1102" @default.
- W2989776685 startingPage "1091" @default.
- W2989776685 abstract "Spin-orbit charge-transfer intersystem crossing (SOCT-ISC) is useful for the preparation of heavy atom-free triplet photosensitisers (PSs). Herein, a series of perylene-Bodipy compact electron donor/acceptor dyads showing efficient SOCT-ISC is prepared. The photophysical properties of the dyads were studied with steady-state and time-resolved spectroscopies. Efficient triplet state formation (quantum yield ΦT =60 %) was observed, with a triplet state lifetime (τT =436 μs) much longer than that accessed with the conventional heavy atom effect (τT =62 μs). The SOCT-ISC mechanism was unambiguously confirmed by direct excitation of the charge transfer (CT) absorption band by using nanosecond transient absorption spectroscopy and time-resolved electron paramagnetic resonance (TREPR) spectroscopy. The factors affecting the SOCT-ISC efficiency include the geometry, the potential energy surface of the torsion, the spin density for the atoms of the linker, solvent polarity, and the energy matching of the 1 CT/3 LE states. Remarkably, these heavy atom-free triplet PSs were demonstrated as a new type of efficient photodynamic therapy (PDT) reagents (phototoxicity, EC50 =75 nm), with a negligible dark toxicity (EC50 =78.1 μm) compared with the conventional heavy atom PSs (dark toxicity, EC50 =6.0 μm, light toxicity, EC50 =4.0 nm). This study provides in-depth understanding of the SOCT-ISC, unveils the design principles of triplet PSs based on SOCT-ISC, and underlines their application as a new generation of potent PDT reagents." @default.
- W2989776685 created "2019-12-05" @default.
- W2989776685 creator A5001769511 @default.
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- W2989776685 creator A5052480136 @default.
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- W2989776685 creator A5066874352 @default.
- W2989776685 date "2020-01-22" @default.
- W2989776685 modified "2023-10-12" @default.
- W2989776685 title "Spin-Orbit Charge-Transfer Intersystem Crossing (ISC) in Compact Electron Donor-Acceptor Dyads: ISC Mechanism and Application as Novel and Potent Photodynamic Therapy Reagents." @default.
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