Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989776766> ?p ?o ?g. }
- W2989776766 endingPage "629" @default.
- W2989776766 startingPage "619" @default.
- W2989776766 abstract "Tumor-associated macrophages (TAMs) constitute a large population of glioblastoma and facilitate tumor growth and invasion of tumor cells, but the underlying mechanism remains undefined. In this study, we demonstrate that chemokine (C-C motif) ligand 8 (CCL8) is highly expressed by TAMs and contributes to pseudopodia formation by GBM cells. The presence of CCL8 in the glioma microenvironment promotes progression of tumor cells. Moreover, CCL8 induces invasion and stem-like traits of GBM cells, and CCR1 and CCR5 are the main receptors that mediate CCL8-induced biological behavior. Finally, CCL8 dramatically activates ERK1/2 phosphorylation in GBM cells, and blocking TAM-secreted CCL8 by neutralized antibody significantly decreases invasion of glioma cells. Taken together, our data reveal that CCL8 is a TAM-associated factor to mediate invasion and stemness of GBM, and targeting CCL8 may provide an insight strategy for GBM treatment." @default.
- W2989776766 created "2019-12-05" @default.
- W2989776766 creator A5013049125 @default.
- W2989776766 creator A5014546886 @default.
- W2989776766 creator A5015235892 @default.
- W2989776766 creator A5015946020 @default.
- W2989776766 creator A5031784842 @default.
- W2989776766 creator A5031804038 @default.
- W2989776766 creator A5036054973 @default.
- W2989776766 creator A5037797754 @default.
- W2989776766 creator A5038627852 @default.
- W2989776766 creator A5054637200 @default.
- W2989776766 creator A5059124207 @default.
- W2989776766 creator A5061261246 @default.
- W2989776766 creator A5065666529 @default.
- W2989776766 creator A5067162679 @default.
- W2989776766 creator A5071074966 @default.
- W2989776766 creator A5087181844 @default.
- W2989776766 creator A5090875147 @default.
- W2989776766 date "2020-04-01" @default.
- W2989776766 modified "2023-10-11" @default.
- W2989776766 title "CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling" @default.
- W2989776766 cites W1499001783 @default.
- W2989776766 cites W1515691577 @default.
- W2989776766 cites W1601336165 @default.
- W2989776766 cites W1867045435 @default.
- W2989776766 cites W1902577542 @default.
- W2989776766 cites W1934903822 @default.
- W2989776766 cites W1967434897 @default.
- W2989776766 cites W1971620413 @default.
- W2989776766 cites W1971728834 @default.
- W2989776766 cites W1979549543 @default.
- W2989776766 cites W1994695419 @default.
- W2989776766 cites W1999879982 @default.
- W2989776766 cites W2001371140 @default.
- W2989776766 cites W2001553859 @default.
- W2989776766 cites W2003604887 @default.
- W2989776766 cites W2006868235 @default.
- W2989776766 cites W2020812892 @default.
- W2989776766 cites W2050573392 @default.
- W2989776766 cites W2060147931 @default.
- W2989776766 cites W2073586533 @default.
- W2989776766 cites W2091218261 @default.
- W2989776766 cites W2098341282 @default.
- W2989776766 cites W2105197802 @default.
- W2989776766 cites W2107110492 @default.
- W2989776766 cites W2114067189 @default.
- W2989776766 cites W2115862526 @default.
- W2989776766 cites W2117692326 @default.
- W2989776766 cites W2126594066 @default.
- W2989776766 cites W2154552023 @default.
- W2989776766 cites W2168694092 @default.
- W2989776766 cites W2175627344 @default.
- W2989776766 cites W2253818064 @default.
- W2989776766 cites W2346941018 @default.
- W2989776766 cites W2377997829 @default.
- W2989776766 cites W2403976714 @default.
- W2989776766 cites W2444414245 @default.
- W2989776766 cites W2519684811 @default.
- W2989776766 cites W2530604244 @default.
- W2989776766 cites W2560005855 @default.
- W2989776766 cites W2560011028 @default.
- W2989776766 cites W2590083437 @default.
- W2989776766 cites W2591531756 @default.
- W2989776766 cites W2595863515 @default.
- W2989776766 cites W2610550910 @default.
- W2989776766 cites W2620943949 @default.
- W2989776766 cites W2620975370 @default.
- W2989776766 cites W2736042082 @default.
- W2989776766 cites W2761714852 @default.
- W2989776766 cites W2770790411 @default.
- W2989776766 cites W2779674702 @default.
- W2989776766 cites W2781656261 @default.
- W2989776766 cites W2782920283 @default.
- W2989776766 cites W2791477629 @default.
- W2989776766 cites W2793835323 @default.
- W2989776766 cites W2795679584 @default.
- W2989776766 cites W2799525027 @default.
- W2989776766 cites W2803030655 @default.
- W2989776766 cites W2885875354 @default.
- W2989776766 cites W2957546294 @default.
- W2989776766 cites W2963349242 @default.
- W2989776766 cites W3011720895 @default.
- W2989776766 cites W894880941 @default.
- W2989776766 doi "https://doi.org/10.1038/s41374-019-0345-3" @default.
- W2989776766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31748682" @default.
- W2989776766 hasPublicationYear "2020" @default.
- W2989776766 type Work @default.
- W2989776766 sameAs 2989776766 @default.
- W2989776766 citedByCount "77" @default.
- W2989776766 countsByYear W29897767662020 @default.
- W2989776766 countsByYear W29897767662021 @default.
- W2989776766 countsByYear W29897767662022 @default.
- W2989776766 countsByYear W29897767662023 @default.
- W2989776766 crossrefType "journal-article" @default.
- W2989776766 hasAuthorship W2989776766A5013049125 @default.
- W2989776766 hasAuthorship W2989776766A5014546886 @default.
- W2989776766 hasAuthorship W2989776766A5015235892 @default.