FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989777767> ?p ?o ?g. }

• W2989777767 abstract "Leukaemia is a family of haematological malignancies and is responsible forapproximately 4500 deaths in the UK annually. Despite extensive research anddevelopment within this disease area over the last decade, there has been littlechange in the overall survival, risk of relapse and side effects, highlighting the needfor improved chemotherapeutics.Lignans are polyphenolic compounds found naturally in plants and have beensuggested to have antioxidant properties and inhibitory effects on the Wnt/s-cateninand the PI3K/Akt cell signalling pathways which are aberrantly activated in leukaemia.A series of eighteen novel compounds have been synthesised based on a naturallignan extract, each with structural modifications to the side chains of each molecule.The effects of the eighteen lignan derivatives on the leukaemia cell line Jurkat wereinvestigated. Biochemical activity as an indirect measure of viability was assessedusing the MTS assay, while apoptosis and necrosis were investigated using theAnnexin V/Propidium Iodide assay. Cell cycle analysis by DNA quantification was alsoperformed to determine any arrest in cycle induced by the compounds. Additionally,Western Blotting analysis was performed on lignan treated cell lysates to identifychanges in protein expression that would suggest effects on the Wnt/s-catenin andthe PI3K/Akt signalling pathways. HSPB1 and HSPA1A expression was analysed todetermine the cellular stress response.Data indicate that the lignan compounds SD007, SD013 and SD018 significantlyaffect cellular metabolism and induce apoptosis following treatment. Cell cycleanalysis demonstrates there is a significant reduction in Jurkat cells entering G2-phase, which further indicates the pro-apoptotic effect of the lignan compounds.Western Blotting analysis suggests there is a cellular stress response induced bylignan compound treatment, due to the increased expression of the stress proteinHSPB1. However, no change in phosphorylated levels of s-catenin or Akt wereobserved, suggesting that these particular lignan compounds have no effect on theWnt/s-catenin or the PI3K/Akt pathways.Further study is necessary to establish the cell signalling cascades affected by lignancompound treatment, however the data obtained highlight lignan compounds SD007,SD013 and SD018 for further development and refinement as anti-leukaemia agents." @default.
• W2989777767 created "2019-12-05" @default.
• W2989777767 creator A5036174936 @default.
• W2989777767 date "2018-02-01" @default.
• W2989777767 modified "2023-09-23" @default.
• W2989777767 title "Examining the role of novel lignan compounds as anti-leukaemia agents" @default.
• W2989777767 cites W1581731557 @default.
• W2989777767 cites W1633424654 @default.
• W2989777767 cites W1757820249 @default.
• W2989777767 cites W1871390418 @default.
• W2989777767 cites W1964333754 @default.
• W2989777767 cites W1969555739 @default.
• W2989777767 cites W1974136307 @default.
• W2989777767 cites W1979129905 @default.
• W2989777767 cites W1982861164 @default.
• W2989777767 cites W1992907775 @default.
• W2989777767 cites W1994682335 @default.
• W2989777767 cites W1994928797 @default.
• W2989777767 cites W2001943317 @default.
• W2989777767 cites W2008616968 @default.
• W2989777767 cites W2008757142 @default.
• W2989777767 cites W2012565727 @default.
• W2989777767 cites W2021033166 @default.
• W2989777767 cites W2039010667 @default.
• W2989777767 cites W2055948179 @default.
• W2989777767 cites W2056641170 @default.
• W2989777767 cites W2057052591 @default.
• W2989777767 cites W2058645214 @default.
• W2989777767 cites W2067038367 @default.
• W2989777767 cites W2089400513 @default.
• W2989777767 cites W2094079572 @default.
• W2989777767 cites W2103756160 @default.
• W2989777767 cites W2107789276 @default.
• W2989777767 cites W2113999888 @default.
• W2989777767 cites W2116446937 @default.
• W2989777767 cites W2125007784 @default.
• W2989777767 cites W2130407823 @default.
• W2989777767 cites W2130616317 @default.
• W2989777767 cites W2132614478 @default.
• W2989777767 cites W2133669258 @default.
• W2989777767 cites W2136850496 @default.
• W2989777767 cites W2170357217 @default.
• W2989777767 cites W2170839629 @default.
• W2989777767 cites W2315298535 @default.
• W2989777767 cites W2334914145 @default.
• W2989777767 cites W2339658711 @default.
• W2989777767 cites W2414542988 @default.
• W2989777767 cites W2414600312 @default.
• W2989777767 cites W2418808650 @default.
• W2989777767 cites W2471919723 @default.
• W2989777767 cites W2474601761 @default.
• W2989777767 cites W2593609957 @default.
• W2989777767 hasPublicationYear "2018" @default.
• W2989777767 type Work @default.
• W2989777767 sameAs 2989777767 @default.
• W2989777767 citedByCount "0" @default.
• W2989777767 crossrefType "dissertation" @default.
• W2989777767 hasAuthorship W2989777767A5036174936 @default.
• W2989777767 hasConcept C105696609 @default.
• W2989777767 hasConcept C137620995 @default.
• W2989777767 hasConcept C179464577 @default.
• W2989777767 hasConcept C185592680 @default.
• W2989777767 hasConcept C190283241 @default.
• W2989777767 hasConcept C203014093 @default.
• W2989777767 hasConcept C2775934118 @default.
• W2989777767 hasConcept C2776090121 @default.
• W2989777767 hasConcept C2781264555 @default.
• W2989777767 hasConcept C29537977 @default.
• W2989777767 hasConcept C31573885 @default.
• W2989777767 hasConcept C502942594 @default.
• W2989777767 hasConcept C53227056 @default.
• W2989777767 hasConcept C55493867 @default.
• W2989777767 hasConcept C62112901 @default.
• W2989777767 hasConcept C62478195 @default.
• W2989777767 hasConcept C71240020 @default.
• W2989777767 hasConcept C75217442 @default.
• W2989777767 hasConcept C86554907 @default.
• W2989777767 hasConcept C86803240 @default.
• W2989777767 hasConcept C8891405 @default.
• W2989777767 hasConcept C98274493 @default.
• W2989777767 hasConceptScore W2989777767C105696609 @default.
• W2989777767 hasConceptScore W2989777767C137620995 @default.
• W2989777767 hasConceptScore W2989777767C179464577 @default.
• W2989777767 hasConceptScore W2989777767C185592680 @default.
• W2989777767 hasConceptScore W2989777767C190283241 @default.
• W2989777767 hasConceptScore W2989777767C203014093 @default.
• W2989777767 hasConceptScore W2989777767C2775934118 @default.
• W2989777767 hasConceptScore W2989777767C2776090121 @default.
• W2989777767 hasConceptScore W2989777767C2781264555 @default.
• W2989777767 hasConceptScore W2989777767C29537977 @default.
• W2989777767 hasConceptScore W2989777767C31573885 @default.
• W2989777767 hasConceptScore W2989777767C502942594 @default.
• W2989777767 hasConceptScore W2989777767C53227056 @default.
• W2989777767 hasConceptScore W2989777767C55493867 @default.
• W2989777767 hasConceptScore W2989777767C62112901 @default.
• W2989777767 hasConceptScore W2989777767C62478195 @default.
• W2989777767 hasConceptScore W2989777767C71240020 @default.
• W2989777767 hasConceptScore W2989777767C75217442 @default.
• W2989777767 hasConceptScore W2989777767C86554907 @default.
• W2989777767 hasConceptScore W2989777767C86803240 @default.

• next