FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989784441> ?p ?o ?g. }

• W2989784441 startingPage "852939" @default.
• W2989784441 abstract "Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer that has a dismal prognosis. Patients with SCLC are uniformly treated with chemotherapy plus radiotherapy and recently with immunotherapy; however, emerging molecular evidence suggests this disease represents heterogeneous groups. At the genomic level, in addition to the near universal loss of p53 and Rb1, the loci for all three Myc family members are frequently amplified in a mutually exclusive manner, suggesting their redundant oncogenic function. However, the expression of these factors is associated with specific neuroendocrine markers and distinct histopathology, and yet the contribution of Myc family members to SCLC molecular subtypes have not been clearly delineated. In this study, we explored a novel role of c-Myc and L-Myc as lineage specific factors contributing to SCLC molecular subtypes and histological classification. Integrated analyses of a Bayesian network generated from primary tumor mRNA expression and chromatin state profiling of SCLC cell lines showed that Myc family members impart distinct transcriptional programs associated with lineage state; wherein L-Myc was enriched for neuronal pathways and c-Myc for Notch signaling and epithelial-to-mesenchymal transition. We investigated the functional redundancy of c-Myc and L-Myc, and noted the insufficiency of L-Myc to induce lineage switch in contrast to the potential of c-Myc to induce trans-differentiation from ASCL1-SCLC to a NeuroD1-SCLC characterized by distinct histopathology. Collectively, our findings reveal a previously undescribed role for historically defined general oncogenes, c-Myc and L-Myc, in regulating lineage plasticity across molecular subtypes as well as histological classes." @default.
• W2989784441 created "2019-12-05" @default.
• W2989784441 creator A5013573755 @default.
• W2989784441 creator A5019337443 @default.
• W2989784441 creator A5020295260 @default.
• W2989784441 creator A5024413045 @default.
• W2989784441 creator A5031229041 @default.
• W2989784441 creator A5034782324 @default.
• W2989784441 creator A5040778303 @default.
• W2989784441 creator A5041362782 @default.
• W2989784441 creator A5056766661 @default.
• W2989784441 creator A5058745924 @default.
• W2989784441 creator A5073509037 @default.
• W2989784441 date "2020-01-23" @default.
• W2989784441 modified "2023-09-27" @default.
• W2989784441 title "Integrative genomic and epigenomic analyses identify a distinct role of c-Myc and L-Myc for lineage determination in small cell lung cancer" @default.
• W2989784441 cites W1572301294 @default.
• W2989784441 cites W1601800607 @default.
• W2989784441 cites W1762727355 @default.
• W2989784441 cites W1778117100 @default.
• W2989784441 cites W1903523058 @default.
• W2989784441 cites W1978286483 @default.
• W2989784441 cites W1978812213 @default.
• W2989784441 cites W1979594866 @default.
• W2989784441 cites W1990320777 @default.
• W2989784441 cites W1996949194 @default.
• W2989784441 cites W2000969961 @default.
• W2989784441 cites W2002404925 @default.
• W2989784441 cites W2008395997 @default.
• W2989784441 cites W2011795445 @default.
• W2989784441 cites W2021341670 @default.
• W2989784441 cites W2021536610 @default.
• W2989784441 cites W2031211461 @default.
• W2989784441 cites W2032972450 @default.
• W2989784441 cites W2044124287 @default.
• W2989784441 cites W2072039942 @default.
• W2989784441 cites W2072684537 @default.
• W2989784441 cites W2073268618 @default.
• W2989784441 cites W2080460005 @default.
• W2989784441 cites W2085213714 @default.
• W2989784441 cites W2088665501 @default.
• W2989784441 cites W2090922694 @default.
• W2989784441 cites W2091588762 @default.
• W2989784441 cites W2100572488 @default.
• W2989784441 cites W2104224322 @default.
• W2989784441 cites W2108927999 @default.
• W2989784441 cites W2117757143 @default.
• W2989784441 cites W2120572492 @default.
• W2989784441 cites W2129163745 @default.
• W2989784441 cites W2146236962 @default.
• W2989784441 cites W2147373929 @default.
• W2989784441 cites W2150122219 @default.
• W2989784441 cites W2152227081 @default.
• W2989784441 cites W2158789637 @default.
• W2989784441 cites W2159290008 @default.
• W2989784441 cites W2161577298 @default.
• W2989784441 cites W2165994277 @default.
• W2989784441 cites W2166032215 @default.
• W2989784441 cites W2171216706 @default.
• W2989784441 cites W2179438025 @default.
• W2989784441 cites W2251438188 @default.
• W2989784441 cites W2252568502 @default.
• W2989784441 cites W2275877493 @default.
• W2989784441 cites W2323326409 @default.
• W2989784441 cites W2342358015 @default.
• W2989784441 cites W2398659594 @default.
• W2989784441 cites W2427872948 @default.
• W2989784441 cites W2465282683 @default.
• W2989784441 cites W2466033276 @default.
• W2989784441 cites W2479269395 @default.
• W2989784441 cites W2540338380 @default.
• W2989784441 cites W2576845640 @default.
• W2989784441 cites W2613058366 @default.
• W2989784441 cites W2617007913 @default.
• W2989784441 cites W2618466363 @default.
• W2989784441 cites W2736545039 @default.
• W2989784441 cites W2749335807 @default.
• W2989784441 cites W2765782352 @default.
• W2989784441 cites W2786927525 @default.
• W2989784441 cites W2810630532 @default.
• W2989784441 cites W2893960509 @default.
• W2989784441 cites W2903473265 @default.
• W2989784441 cites W2911188335 @default.
• W2989784441 cites W2913103186 @default.
• W2989784441 cites W2928432651 @default.
• W2989784441 cites W2965991774 @default.
• W2989784441 cites W2975867837 @default.
• W2989784441 cites W2985308469 @default.
• W2989784441 hasPublicationYear "2020" @default.
• W2989784441 type Work @default.
• W2989784441 sameAs 2989784441 @default.
• W2989784441 citedByCount "0" @default.
• W2989784441 crossrefType "posted-content" @default.
• W2989784441 hasAuthorship W2989784441A5013573755 @default.
• W2989784441 hasAuthorship W2989784441A5019337443 @default.
• W2989784441 hasAuthorship W2989784441A5020295260 @default.
• W2989784441 hasAuthorship W2989784441A5024413045 @default.
• W2989784441 hasAuthorship W2989784441A5031229041 @default.
• W2989784441 hasAuthorship W2989784441A5034782324 @default.

• next