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- W2989792802 abstract "Introduction: Five percent of the released cesium-137 (Cs-137) from the Chernobyl nuclear power plant accident in 1986 was deposited in Sweden. We studied the total cancer incidence using parish versus individual levels of exposure. Results from the two methods will be compared. Methods: A digital map on the deposition of Cs-137 in kiloBecquerel/m2 (kBq/m2) from the Geological Survey of Sweden was used to create a surface-weighted average at parish level (n=612) for 9 counties in 1986. An individual 5-year cumulative exposure value was calculated from the deposition at the annual dwelling coordinate, in the three most contaminated counties, taking into account the physical decay of Cs-137 and changing of the residence 1986-1990 (n=734,537). From the National Board of Welfare 222,467 cancer cases 1986-2009 and 82,495 cancer cases 1991-2010 was retrieved, respectively. The total cancer incidence rate ratio (IRR) was calculated with Poisson regression and Hazard Ratio (HR) with Cox regression, respectively. The risk estimates were adjusted for several potential confounding factors. Results: In the ecological study design no obvious exposure-response using IRR was revealed for five exposure categories. Using individual exposure data, the adjusted HRs (95% CI) were 1.03 (1.01 to 1.05) for intermediate exposure (45.41 to 118.8 kBq/m2) and 1.05 (1.03 to 1.07) for highest exposure (118.81 to 564.71 kBq/m2) comparing to the reference exposure (0.0 to 45.4 kBq/m2). Conclusions: Using individual exposure assessment revealed a weak exposure response trend, not seen in the ecological study design. Strength and limitations with the two methods will be discussed in terms of ecological bias and statistical power." @default.
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- W2989792802 date "2016-08-17" @default.
- W2989792802 modified "2023-09-26" @default.
- W2989792802 title "Total cancer incidence in Sweden after the Chernobyl accident – can better precision be achieved using individual exposure assessments over time?" @default.
- W2989792802 doi "https://doi.org/10.1289/isee.2016.3429" @default.
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