Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989796511> ?p ?o ?g. }
- W2989796511 endingPage "104610" @default.
- W2989796511 startingPage "104610" @default.
- W2989796511 abstract "Our previous data indicated that tanshinone IIA (tan IIA) improves learning and memory in a mouse model of Alzheimer's disease (AD) induced by streptozotocin via restoring cholinergic function, attenuating oxidative stress and blocking p38 MAPK signal pathway activation. This study aims to estimate whether tan IIA inhibits endoplasmic reticulum (ER) stress-induced apoptosis to prevent cognitive decline in APP/PS1 transgenic mice. Tan IIA (10 mg/kg and 30 mg/kg) was intraperitoneally administered to the six-month-old APP/PS1 mice for 30 consecutive days. β-amyloid (Aβ) plaques were measured by immunohistochemisty and Thioflavin S staining, apoptotic cells were observed by TUNEL, ER stress markers and apoptosis signaling proteins were investigated by western blotting and RT-PCR. Our results showed that tan IIA significantly ameliorates cognitive deficits and improves spatial learning ability of APP/PS1 mice in the nest-building test, novel object recognition test and Morris water maze test. Furthermore, tan IIA significantly reduced the deposition of Aβ plaques and neuronal apoptosis, and markedly prevented abnormal expression of glucose regulated protein 78 (GRP78), initiation factor 2α (eIF2α), inositol-requiring enzyme 1α (IRE1α), activating transcription factor 6 (ATF6), as well as suppressed the activation of C/EBP homologous protein (CHOP) and c-Jun N-terminal kinase (JNK) pathways in the parietal cortex and hippocampus. Moreover, tan IIA induced an up-regulation of the Bcl-2/Bax ratio and down-regulation of caspase-3 protein activity. Taken together, the above findings indicated that tan IIA improves learning and memory through attenuating Aβ plaques deposition and inhibiting ER stress-induced apoptosis. These results suggested that tan IIA might become a promising therapeutic candidate drug against AD." @default.
- W2989796511 created "2019-12-05" @default.
- W2989796511 creator A5009487867 @default.
- W2989796511 creator A5023868586 @default.
- W2989796511 creator A5032712965 @default.
- W2989796511 creator A5035351509 @default.
- W2989796511 creator A5035621752 @default.
- W2989796511 creator A5037498188 @default.
- W2989796511 creator A5038253545 @default.
- W2989796511 creator A5043187917 @default.
- W2989796511 creator A5057230461 @default.
- W2989796511 creator A5064384299 @default.
- W2989796511 creator A5067939855 @default.
- W2989796511 creator A5069051352 @default.
- W2989796511 creator A5069793270 @default.
- W2989796511 creator A5073373311 @default.
- W2989796511 creator A5083177291 @default.
- W2989796511 creator A5089972275 @default.
- W2989796511 date "2020-02-01" @default.
- W2989796511 modified "2023-10-17" @default.
- W2989796511 title "Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice" @default.
- W2989796511 cites W1014881830 @default.
- W2989796511 cites W1516732342 @default.
- W2989796511 cites W1546139069 @default.
- W2989796511 cites W1602771322 @default.
- W2989796511 cites W1607777232 @default.
- W2989796511 cites W1920854830 @default.
- W2989796511 cites W1963775403 @default.
- W2989796511 cites W1977258127 @default.
- W2989796511 cites W1983820911 @default.
- W2989796511 cites W1993777187 @default.
- W2989796511 cites W1998309754 @default.
- W2989796511 cites W2006231600 @default.
- W2989796511 cites W2008046168 @default.
- W2989796511 cites W2014787832 @default.
- W2989796511 cites W2016385757 @default.
- W2989796511 cites W2018496654 @default.
- W2989796511 cites W2019184335 @default.
- W2989796511 cites W2019263782 @default.
- W2989796511 cites W2019987942 @default.
- W2989796511 cites W2020230600 @default.
- W2989796511 cites W2022577384 @default.
- W2989796511 cites W2023403026 @default.
- W2989796511 cites W2023973572 @default.
- W2989796511 cites W2027604252 @default.
- W2989796511 cites W2027895574 @default.
- W2989796511 cites W2030934338 @default.
- W2989796511 cites W2033030397 @default.
- W2989796511 cites W2043718270 @default.
- W2989796511 cites W2047363194 @default.
- W2989796511 cites W2054473727 @default.
- W2989796511 cites W2055296293 @default.
- W2989796511 cites W2055355505 @default.
- W2989796511 cites W2060609158 @default.
- W2989796511 cites W2063943153 @default.
- W2989796511 cites W2076485183 @default.
- W2989796511 cites W2077464099 @default.
- W2989796511 cites W2080901528 @default.
- W2989796511 cites W2094850025 @default.
- W2989796511 cites W2098075121 @default.
- W2989796511 cites W2106749088 @default.
- W2989796511 cites W2127589318 @default.
- W2989796511 cites W2129078779 @default.
- W2989796511 cites W2129085204 @default.
- W2989796511 cites W2140607486 @default.
- W2989796511 cites W2145509877 @default.
- W2989796511 cites W2159586070 @default.
- W2989796511 cites W2162531352 @default.
- W2989796511 cites W2167500696 @default.
- W2989796511 cites W2168116860 @default.
- W2989796511 cites W2172053085 @default.
- W2989796511 cites W2182357122 @default.
- W2989796511 cites W219506686 @default.
- W2989796511 cites W2236885736 @default.
- W2989796511 cites W2323628228 @default.
- W2989796511 cites W2324923772 @default.
- W2989796511 cites W2466188809 @default.
- W2989796511 cites W2507677440 @default.
- W2989796511 cites W2542776108 @default.
- W2989796511 cites W2546671354 @default.
- W2989796511 cites W2546781160 @default.
- W2989796511 cites W2555889096 @default.
- W2989796511 cites W2570314532 @default.
- W2989796511 cites W2588240249 @default.
- W2989796511 cites W2588627065 @default.
- W2989796511 cites W2603515519 @default.
- W2989796511 cites W2606084899 @default.
- W2989796511 cites W2618165770 @default.
- W2989796511 cites W2742971656 @default.
- W2989796511 cites W2743889267 @default.
- W2989796511 cites W2750871125 @default.
- W2989796511 cites W2751463354 @default.
- W2989796511 cites W2761459420 @default.
- W2989796511 cites W2766900039 @default.
- W2989796511 cites W2768408309 @default.
- W2989796511 cites W2772202429 @default.
- W2989796511 cites W2781904813 @default.
- W2989796511 cites W2782493947 @default.