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• W2989803410 endingPage "104622" @default.
• W2989803410 startingPage "104622" @default.
• W2989803410 abstract "This study was aimed at examining the role of Tenascin-C in T cell trafficking in Oral Lichen Planus (OLP). For the in vivo immunohistochemical analyses, 115 OLP samples were collected from patients and immunostaining was performed. The intensity and distribution of TN-C expression were quantified and correlated with histological analyses of basement membrane integrity and presence of inflammatory infiltrate. For the in vitro study, TN-C and collagen were coated on culture plates and migration of T lymphocytes was assessed. TN-C immunoexpression was increased in terms of both distribution and intensity along the basement membrane zone. These changes were significantly associated with basement membrane duplication (distribution p < 0.002 and intensity p < 0.001) and bands of inflammation (distribution p < 0.002 and intensity p < 0.001) assessed by Chi-square test. T lymphocytes demonstrated significant migration towards TN-C as compared to collagen (n = 3, p < 0.05). These findings indicate TN-C may have a key role in promoting T cell migration at the epithelial-mesenchymal junction in OLP. These observations suggest TN-C could be a good target for therapeutic intervention, either in itself or synergistically with anti-inflammatory directed strategies in this chronic disease management." @default.
• W2989803410 created "2019-12-05" @default.
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• W2989803410 date "2020-02-01" @default.
• W2989803410 modified "2023-10-16" @default.
• W2989803410 title "Roles of the matricellular protein Tenascin-C in T-lymphocyte trafficking and etiopathogenesis of Oral Lichen Planus" @default.
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• W2989803410 doi "https://doi.org/10.1016/j.archoralbio.2019.104622" @default.
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