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- W2989809912 abstract "Recently, the use of chimeric antigen receptor-modified T (CAR-T)-cells in the treatment of hematological tumors has been successful and has become a clinical hotspot in tumor immunotherapy. However, their wide application is limited by inherent risks such as graft-versus-host disease (GvHD) and the amount of time it takes to produce CAR-T cells. Natural killer (NK) cells can be xenografted and have the potential to become off-the-shelf products, making CAR-NK cell therapies universal products. These products may be safer than CAR-T cell therapy. Considering that the fundamental researche is still in its infancy, this review focuses on clinical achievements and new strategies for improving the safety and efficacy of CAR-NK cell therapy, as well as the corresponding challenges." @default.
- W2989809912 created "2019-12-05" @default.
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- W2989809912 date "2020-03-01" @default.
- W2989809912 modified "2023-10-02" @default.
- W2989809912 title "CAR-NK for tumor immunotherapy: Clinical transformation and future prospects" @default.
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- W2989809912 doi "https://doi.org/10.1016/j.canlet.2019.11.033" @default.
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