FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989827657> ?p ?o ?g. }

• W2989827657 endingPage "723" @default.
• W2989827657 startingPage "711" @default.
• W2989827657 abstract "Abstract Background CCL22 played critical roles in Tregs recruitment. The upstream regulators modulating CCL22 in hepatocellular carcinoma (HCC) were not clearly understood. Methods MiR‐23a, p‐p65, p65, CCL22, and Foxp3 levels were monitored by RT‐qPCR and western blotting. Immunofluorescence assay was used to perform the costaining of Foxp3 and CD4 on liver tissues. Transwell assay was applied to evaluate the migration ability of Tregs. Dual‐luciferase assay was performed to determine relationship of miR‐23a/CCL22 and p65/miR‐23a. Chromatin immunoprecipitation (ChIP) was applied to detect the direct binding of p65 to miR‐23a promoter. Xenograft tumor models were developed to investigate the functions of p65 and miR‐23a in vivo. Results HBV infection was associated with reduced survival and increased Tregs recruitment in HCC patients. MiR‐23a was decreased, whereas p65, CCL22, and Foxp3 were increased in HBV + tumors. MiR‐23a was inversely correlated with CCL22 and Foxp3 expression in HCC. MiR‐23a directly targeted CCL22 3’UTR, leading to CCL22 reduction and attenuated Tregs recruitment. Meanwhile, p65 functioned as a transcription repressor of miR‐23a by directly binding to its promoter. Inhibition of p65 induced miR‐23 expression, leading to less CCL22 expression and Tregs recruitment in vitro. CCL22 was the indispensable effector underlying p65/miR‐23a axis and Tregs recruitment. MiR‐23a inhibitor promoted xenografted tumor growth accompanying with upregulation of CCL22, whereas p65 inhibition exerted opposite effects. Conclusion Blockage of p65 disinhibited miR‐23a expression, leading to CCL22 reduction and repress Tregs recruitment. Targeting p65/miR‐23a/CCL22 axis was a novel approach for HBV + HCC treatment." @default.
• W2989827657 created "2019-12-05" @default.
• W2989827657 creator A5005461646 @default.
• W2989827657 creator A5017521861 @default.
• W2989827657 creator A5065901082 @default.
• W2989827657 creator A5066043547 @default.
• W2989827657 creator A5070313686 @default.
• W2989827657 creator A5083588367 @default.
• W2989827657 creator A5084704902 @default.
• W2989827657 date "2019-11-25" @default.
• W2989827657 modified "2023-10-16" @default.
• W2989827657 title "p65/miR‐23a/CCL22 axis regulated regulatory T cells recruitment in hepatitis B virus positive hepatocellular carcinoma" @default.
• W2989827657 cites W1770263627 @default.
• W2989827657 cites W1966832659 @default.
• W2989827657 cites W1976777085 @default.
• W2989827657 cites W1984484036 @default.
• W2989827657 cites W1999493028 @default.
• W2989827657 cites W2007868505 @default.
• W2989827657 cites W2044091978 @default.
• W2989827657 cites W2049964698 @default.
• W2989827657 cites W2062030781 @default.
• W2989827657 cites W2068275410 @default.
• W2989827657 cites W2073310925 @default.
• W2989827657 cites W2099805214 @default.
• W2989827657 cites W2107336310 @default.
• W2989827657 cites W2116576993 @default.
• W2989827657 cites W2129741568 @default.
• W2989827657 cites W2167428016 @default.
• W2989827657 cites W2272984102 @default.
• W2989827657 cites W2338611861 @default.
• W2989827657 cites W2345568581 @default.
• W2989827657 cites W2419439766 @default.
• W2989827657 cites W2519455024 @default.
• W2989827657 cites W2527534199 @default.
• W2989827657 cites W2623003466 @default.
• W2989827657 cites W2782949806 @default.
• W2989827657 cites W2899385209 @default.
• W2989827657 doi "https://doi.org/10.1002/cam4.2611" @default.
• W2989827657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6970059" @default.
• W2989827657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31769216" @default.
• W2989827657 hasPublicationYear "2019" @default.
• W2989827657 type Work @default.
• W2989827657 sameAs 2989827657 @default.
• W2989827657 citedByCount "8" @default.
• W2989827657 countsByYear W29898276572021 @default.
• W2989827657 countsByYear W29898276572022 @default.
• W2989827657 countsByYear W29898276572023 @default.
• W2989827657 crossrefType "journal-article" @default.
• W2989827657 hasAuthorship W2989827657A5005461646 @default.
• W2989827657 hasAuthorship W2989827657A5017521861 @default.
• W2989827657 hasAuthorship W2989827657A5065901082 @default.
• W2989827657 hasAuthorship W2989827657A5066043547 @default.
• W2989827657 hasAuthorship W2989827657A5070313686 @default.
• W2989827657 hasAuthorship W2989827657A5083588367 @default.
• W2989827657 hasAuthorship W2989827657A5084704902 @default.
• W2989827657 hasBestOaLocation W29898276571 @default.
• W2989827657 hasConcept C101762097 @default.
• W2989827657 hasConcept C104317684 @default.
• W2989827657 hasConcept C127561419 @default.
• W2989827657 hasConcept C13373296 @default.
• W2989827657 hasConcept C134320426 @default.
• W2989827657 hasConcept C134678942 @default.
• W2989827657 hasConcept C150194340 @default.
• W2989827657 hasConcept C153911025 @default.
• W2989827657 hasConcept C173396325 @default.
• W2989827657 hasConcept C185592680 @default.
• W2989827657 hasConcept C190283241 @default.
• W2989827657 hasConcept C203014093 @default.
• W2989827657 hasConcept C2776415932 @default.
• W2989827657 hasConcept C2776914184 @default.
• W2989827657 hasConcept C2778019345 @default.
• W2989827657 hasConcept C2779727006 @default.
• W2989827657 hasConcept C502942594 @default.
• W2989827657 hasConcept C55493867 @default.
• W2989827657 hasConcept C5858377 @default.
• W2989827657 hasConcept C86803240 @default.
• W2989827657 hasConcept C8891405 @default.
• W2989827657 hasConceptScore W2989827657C101762097 @default.
• W2989827657 hasConceptScore W2989827657C104317684 @default.
• W2989827657 hasConceptScore W2989827657C127561419 @default.
• W2989827657 hasConceptScore W2989827657C13373296 @default.
• W2989827657 hasConceptScore W2989827657C134320426 @default.
• W2989827657 hasConceptScore W2989827657C134678942 @default.
• W2989827657 hasConceptScore W2989827657C150194340 @default.
• W2989827657 hasConceptScore W2989827657C153911025 @default.
• W2989827657 hasConceptScore W2989827657C173396325 @default.
• W2989827657 hasConceptScore W2989827657C185592680 @default.
• W2989827657 hasConceptScore W2989827657C190283241 @default.
• W2989827657 hasConceptScore W2989827657C203014093 @default.
• W2989827657 hasConceptScore W2989827657C2776415932 @default.
• W2989827657 hasConceptScore W2989827657C2776914184 @default.
• W2989827657 hasConceptScore W2989827657C2778019345 @default.
• W2989827657 hasConceptScore W2989827657C2779727006 @default.
• W2989827657 hasConceptScore W2989827657C502942594 @default.
• W2989827657 hasConceptScore W2989827657C55493867 @default.
• W2989827657 hasConceptScore W2989827657C5858377 @default.
• W2989827657 hasConceptScore W2989827657C86803240 @default.
• W2989827657 hasConceptScore W2989827657C8891405 @default.

• next