FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989835412> ?p ?o ?g. }

• W2989835412 endingPage "48351" @default.
• W2989835412 startingPage "48341" @default.
• W2989835412 abstract "Extracorporeal blood purification has been applied to artificially support kidney or liver function. However, convection and diffusion based blood purification systems have limited removal rates for high molecular weight and hydrophobic molecules. This limitation is due to the finite volume of infusion and limited membrane permeability, respectively. Adsorption provides an attractive alternative for the removal of higher molecular weight compounds. The use of adsorption resins containing ion exchanging groups to capture specific molecules has become well-established. Instead of stationary adsorption resins, however, ion exchanging polymers may be immobilized on magnetic particles and serve as freely diffusing, mobile, high capacity solid phase of ion exchange chromatography. While small beads with high surface area are attractive in terms of mass transfer and binding, unifying high capturing capacity with rapid and quantitative bead recovery remains an issue. Therefore, most of the current magnetic ion exchangers are based on micron-sized beads or require long times to separate. In addition to unfavorable magnetic recovery rates, the usually poor cytocompatibility limits their applicability in biomedicine. Here, we report on the synthesis and performance of polycationic polymer coated magnetic nanoflowers (MNF) for highly efficacious anion capturing. We demonstrate accurate control over the polymer content and composition on the beads and show its direct influence on colloidal stability, capturing capacity and magnetic separability. We present the removal of clinically relevant targets by capturing bilirubin with capacities 2-fold higher than previous work as well as quantitative heparin removal. Additionally, we illustrate how copolymerization of poly(2-dimethylaminoethyl methacrylate) (PDMAEMA) with poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) leads to improved cytocompatibility of the polymer-coated MNF capturing agents while retaining high capturing capacities. Taken together, we present a nanoparticle/polymer material, which upon future in vivo validation, unifies high binding capacities and magnetic separability for rapid toxin capturing and hence fulfills key requirements of clinical utility." @default.
• W2989835412 created "2019-12-05" @default.
• W2989835412 creator A5016491169 @default.
• W2989835412 creator A5025498674 @default.
• W2989835412 creator A5057997425 @default.
• W2989835412 creator A5065743386 @default.
• W2989835412 creator A5065773854 @default.
• W2989835412 creator A5089699712 @default.
• W2989835412 creator A5090791177 @default.
• W2989835412 date "2019-11-20" @default.
• W2989835412 modified "2023-10-10" @default.
• W2989835412 title "Tailoring the Colloidal Stability, Magnetic Separability, and Cytocompatibility of High-Capacity Magnetic Anion Exchangers" @default.
• W2989835412 cites W1502491580 @default.
• W2989835412 cites W1513769470 @default.
• W2989835412 cites W1973167045 @default.
• W2989835412 cites W1981286557 @default.
• W2989835412 cites W1983310615 @default.
• W2989835412 cites W1995980785 @default.
• W2989835412 cites W2007328831 @default.
• W2989835412 cites W2013440195 @default.
• W2989835412 cites W2017361213 @default.
• W2989835412 cites W2018281666 @default.
• W2989835412 cites W2022216415 @default.
• W2989835412 cites W2028708311 @default.
• W2989835412 cites W2040330716 @default.
• W2989835412 cites W2053122447 @default.
• W2989835412 cites W2056179603 @default.
• W2989835412 cites W2059394241 @default.
• W2989835412 cites W2065261900 @default.
• W2989835412 cites W2085129412 @default.
• W2989835412 cites W2089761251 @default.
• W2989835412 cites W2094420176 @default.
• W2989835412 cites W2097773191 @default.
• W2989835412 cites W2110167268 @default.
• W2989835412 cites W2115750472 @default.
• W2989835412 cites W2123593234 @default.
• W2989835412 cites W2134999083 @default.
• W2989835412 cites W2147288955 @default.
• W2989835412 cites W2153418628 @default.
• W2989835412 cites W2222581669 @default.
• W2989835412 cites W2278743203 @default.
• W2989835412 cites W2284929535 @default.
• W2989835412 cites W2311164244 @default.
• W2989835412 cites W2402758384 @default.
• W2989835412 cites W2479122830 @default.
• W2989835412 cites W2499849206 @default.
• W2989835412 cites W2500645278 @default.
• W2989835412 cites W2530830834 @default.
• W2989835412 cites W2571904867 @default.
• W2989835412 cites W2614325343 @default.
• W2989835412 cites W2749004094 @default.
• W2989835412 cites W2785812992 @default.
• W2989835412 cites W2792545890 @default.
• W2989835412 cites W2884931955 @default.
• W2989835412 cites W2933206117 @default.
• W2989835412 cites W4211193493 @default.
• W2989835412 cites W4242966060 @default.
• W2989835412 doi "https://doi.org/10.1021/acsami.9b16619" @default.
• W2989835412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31747521" @default.
• W2989835412 hasPublicationYear "2019" @default.
• W2989835412 type Work @default.
• W2989835412 sameAs 2989835412 @default.
• W2989835412 citedByCount "8" @default.
• W2989835412 countsByYear W29898354122020 @default.
• W2989835412 countsByYear W29898354122021 @default.
• W2989835412 countsByYear W29898354122022 @default.
• W2989835412 countsByYear W29898354122023 @default.
• W2989835412 crossrefType "journal-article" @default.
• W2989835412 hasAuthorship W2989835412A5016491169 @default.
• W2989835412 hasAuthorship W2989835412A5025498674 @default.
• W2989835412 hasAuthorship W2989835412A5057997425 @default.
• W2989835412 hasAuthorship W2989835412A5065743386 @default.
• W2989835412 hasAuthorship W2989835412A5065773854 @default.
• W2989835412 hasAuthorship W2989835412A5089699712 @default.
• W2989835412 hasAuthorship W2989835412A5090791177 @default.
• W2989835412 hasBestOaLocation W29898354122 @default.
• W2989835412 hasConcept C127413603 @default.
• W2989835412 hasConcept C132050475 @default.
• W2989835412 hasConcept C150394285 @default.
• W2989835412 hasConcept C15920480 @default.
• W2989835412 hasConcept C159985019 @default.
• W2989835412 hasConcept C178790620 @default.
• W2989835412 hasConcept C185592680 @default.
• W2989835412 hasConcept C192562407 @default.
• W2989835412 hasConcept C41625074 @default.
• W2989835412 hasConcept C42360764 @default.
• W2989835412 hasConcept C43617362 @default.
• W2989835412 hasConcept C521977710 @default.
• W2989835412 hasConcept C55493867 @default.
• W2989835412 hasConcept C59789625 @default.
• W2989835412 hasConceptScore W2989835412C127413603 @default.
• W2989835412 hasConceptScore W2989835412C132050475 @default.
• W2989835412 hasConceptScore W2989835412C150394285 @default.
• W2989835412 hasConceptScore W2989835412C15920480 @default.
• W2989835412 hasConceptScore W2989835412C159985019 @default.
• W2989835412 hasConceptScore W2989835412C178790620 @default.
• W2989835412 hasConceptScore W2989835412C185592680 @default.
• W2989835412 hasConceptScore W2989835412C192562407 @default.

• next