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- W2989873670 abstract "Breakthrough technologies for monitoring and manipulating single-neuron activity provide unprecedented opportunities for whole-brain neuroscience in larval zebrafish 1–9 . Understanding the neural mechanisms of visually guided behavior also requires precise stimulus control, but little prior research has accounted for physical distortions that result from refraction and reflection at an air-water interface that usually separates the projected stimulus from the fish 10–12 . Here we provide a computational tool that transforms between projected and received stimuli in order to detect and control these distortions. The tool considers the most commonly encountered interface geometry, and we show that this and other common configurations produce stereotyped distortions. By correcting these distortions, we reduced discrepancies in the literature concerning stimuli that evoke escape behavior 13,14 , and we expect this tool will help reconcile other confusing aspects of the literature. This tool also aids experimental design, and we illustrate the dangers that uncorrected stimuli pose to receptive field mapping experiments." @default.
- W2989873670 created "2019-12-05" @default.
- W2989873670 creator A5049222747 @default.
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- W2989873670 date "2019-11-25" @default.
- W2989873670 modified "2023-10-18" @default.
- W2989873670 title "Correcting for physical distortions in visual stimuli improves reproducibility in zebrafish neuroscience" @default.
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- W2989873670 doi "https://doi.org/10.1101/852962" @default.
- W2989873670 hasPublicationYear "2019" @default.
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