FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2989878150> ?p ?o ?g. }

• W2989878150 abstract "The current approach to systemic therapy for metastatic cancer is aimed predominantly at inducing apoptosis of cancer cells by blocking tumor-promoting signaling pathways or by eradicating cell compartments within the tumor. In contrast, a systems view of therapy primarily considers the communication protocols that exist at multiple levels within the tumor complex, and the role of key regulators of such systems. Such regulators may have far-reaching influence on tumor response to therapy and therefore patient survival. This implies that neoplasia may be considered as a cell non-autonomous disease. The multi-scale activity ranges from intra-tumor cell compartments, to the tumor, to the tumor-harboring organ to the organism. In contrast to molecularly targeted therapies, a systems approach that identifies the complex communications networks driving tumor growth offers the prospect of disrupting or ‘normalizing’ such aberrant communicative behaviors and therefore attenuating tumor growth. Communicative reprogramming, a treatment strategy referred to as anakoinosis, requires novel therapeutic instruments, so-called master modulators to deliver concerted tumor growth-attenuating action. The diversity of biological outcomes following pro-anakoinotic tumor therapy, such as differentiation, trans-differentiation, control of tumor-associated inflammation, etc. demonstrates that long-term tumor control may occur in multiple forms, inducing even continuous complete remission. Accordingly, pro-anakoinotic therapies dramatically extend the repertoire for achieving tumor control and may activate apoptosis pathways for controlling resistant metastatic tumor disease and hematologic neoplasia." @default.
• W2989878150 created "2019-12-05" @default.
• W2989878150 creator A5001678596 @default.
• W2989878150 creator A5010961409 @default.
• W2989878150 creator A5023978460 @default.
• W2989878150 creator A5035889786 @default.
• W2989878150 creator A5037052642 @default.
• W2989878150 creator A5040663053 @default.
• W2989878150 creator A5041945240 @default.
• W2989878150 creator A5043156173 @default.
• W2989878150 creator A5061498879 @default.
• W2989878150 creator A5082924805 @default.
• W2989878150 date "2019-12-20" @default.
• W2989878150 modified "2023-09-30" @default.
• W2989878150 title "Anakoinosis: Correcting Aberrant Homeostasis of Cancer Tissue—Going Beyond Apoptosis Induction" @default.
• W2989878150 cites W1157613785 @default.
• W2989878150 cites W1201845303 @default.
• W2989878150 cites W1718522256 @default.
• W2989878150 cites W1871744313 @default.
• W2989878150 cites W1899346463 @default.
• W2989878150 cites W1956871134 @default.
• W2989878150 cites W1964083798 @default.
• W2989878150 cites W1966169774 @default.
• W2989878150 cites W1969466735 @default.
• W2989878150 cites W1975634611 @default.
• W2989878150 cites W1976956469 @default.
• W2989878150 cites W1978486653 @default.
• W2989878150 cites W1979771716 @default.
• W2989878150 cites W1982013294 @default.
• W2989878150 cites W1985585626 @default.
• W2989878150 cites W1995247938 @default.
• W2989878150 cites W1996784808 @default.
• W2989878150 cites W1998997365 @default.
• W2989878150 cites W2006953602 @default.
• W2989878150 cites W2010069724 @default.
• W2989878150 cites W2012411473 @default.
• W2989878150 cites W2016279534 @default.
• W2989878150 cites W2016540525 @default.
• W2989878150 cites W2018192635 @default.
• W2989878150 cites W2019818831 @default.
• W2989878150 cites W2021757510 @default.
• W2989878150 cites W2023255625 @default.
• W2989878150 cites W2023800044 @default.
• W2989878150 cites W2025039763 @default.
• W2989878150 cites W2031204755 @default.
• W2989878150 cites W2034131665 @default.
• W2989878150 cites W2034683528 @default.
• W2989878150 cites W2037796411 @default.
• W2989878150 cites W2038802455 @default.
• W2989878150 cites W2039109621 @default.
• W2989878150 cites W2044433401 @default.
• W2989878150 cites W2050586333 @default.
• W2989878150 cites W2051476191 @default.
• W2989878150 cites W2061943708 @default.
• W2989878150 cites W2063281635 @default.
• W2989878150 cites W2065033398 @default.
• W2989878150 cites W2066511043 @default.
• W2989878150 cites W2070434448 @default.
• W2989878150 cites W2073531001 @default.
• W2989878150 cites W2075452470 @default.
• W2989878150 cites W2077813812 @default.
• W2989878150 cites W2077922697 @default.
• W2989878150 cites W2078424139 @default.
• W2989878150 cites W2081101433 @default.
• W2989878150 cites W2081410358 @default.
• W2989878150 cites W2084623259 @default.
• W2989878150 cites W2097689792 @default.
• W2989878150 cites W2098627399 @default.
• W2989878150 cites W2099628605 @default.
• W2989878150 cites W2101487191 @default.
• W2989878150 cites W2104277739 @default.
• W2989878150 cites W2104400024 @default.
• W2989878150 cites W2106543129 @default.
• W2989878150 cites W2108625211 @default.
• W2989878150 cites W2120858407 @default.
• W2989878150 cites W2121371748 @default.
• W2989878150 cites W2121463199 @default.
• W2989878150 cites W2122113546 @default.
• W2989878150 cites W2124097936 @default.
• W2989878150 cites W2124231680 @default.
• W2989878150 cites W2125974203 @default.
• W2989878150 cites W2127924361 @default.
• W2989878150 cites W2137417501 @default.
• W2989878150 cites W2138652650 @default.
• W2989878150 cites W2139877745 @default.
• W2989878150 cites W2140620553 @default.
• W2989878150 cites W2148848757 @default.
• W2989878150 cites W2152454229 @default.
• W2989878150 cites W2152854378 @default.
• W2989878150 cites W2156482394 @default.
• W2989878150 cites W2157912474 @default.
• W2989878150 cites W2157952326 @default.
• W2989878150 cites W2158095489 @default.
• W2989878150 cites W2159473577 @default.
• W2989878150 cites W2160631087 @default.
• W2989878150 cites W2163544987 @default.
• W2989878150 cites W2163692077 @default.
• W2989878150 cites W2166706309 @default.
• W2989878150 cites W2169101531 @default.
• W2989878150 cites W2170828959 @default.

• next