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- W2989888510 abstract "Protein phosphorylation is an important type of post-translational modification that regulates various activities of cell life inside human body. The accurate identification of phosphorylation sites can provide new insights for revealing the specific function of protein. However, it is time-consuming and inefficient to apply the experiment-based techniques in investigating the phosphorylation sites in proteins. Additionally, computational approaches are regarded as an ideal choice in such a big data era. Therefore, in this work, we designed a new computational method to identify phosphorylation sites. At first, phosphorylation data was collected from human proteins to construct an objective and strict benchmark dataset. By a series of feature analysis, we found that the distributions of conservation scores and nine physicochemical properties surrounding the phosphorylation sites in positive samples are significantly different from those surrounding non-phosphorylation sites in negative samples. Based on these features, a novel sequence-based method for predicting the phosphorylation sites in human proteomics was proposed, which incorporated the conservation scores with position-associated attributes that reflect the correlation of physicochemical characteristics among amino acid residues. Furthermore, the analysis of variance (ANOVA) was utilized to obtain the optimal feature subset which could produce the highest accuracy. Comparison with the published predictor demonstrated the superiority of our predictor. Finally, a user-friendly online tool called iPhoPred was established and can be freely available at http://lin-group.cn/server/iPhoPred/ . We hope the tool will provide important guide for the study of protein phosphorylation." @default.
- W2989888510 created "2019-12-05" @default.
- W2989888510 creator A5016326689 @default.
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- W2989888510 creator A5043530440 @default.
- W2989888510 creator A5062628676 @default.
- W2989888510 creator A5081278212 @default.
- W2989888510 date "2019-01-01" @default.
- W2989888510 modified "2023-10-17" @default.
- W2989888510 title "iPhoPred: A Predictor for Identifying Phosphorylation Sites in Human Protein" @default.
- W2989888510 cites W1253096047 @default.
- W2989888510 cites W1970447461 @default.
- W2989888510 cites W1975667302 @default.
- W2989888510 cites W1976978745 @default.
- W2989888510 cites W1993996526 @default.
- W2989888510 cites W1995989434 @default.
- W2989888510 cites W2007321142 @default.
- W2989888510 cites W2026029065 @default.
- W2989888510 cites W2038873127 @default.
- W2989888510 cites W2057000344 @default.
- W2989888510 cites W2071952037 @default.
- W2989888510 cites W2076573118 @default.
- W2989888510 cites W2079056345 @default.
- W2989888510 cites W2084868992 @default.
- W2989888510 cites W2088117005 @default.
- W2989888510 cites W2091374952 @default.
- W2989888510 cites W2093567555 @default.
- W2989888510 cites W2100984467 @default.
- W2989888510 cites W2104244040 @default.
- W2989888510 cites W2109383935 @default.
- W2989888510 cites W2110498021 @default.
- W2989888510 cites W2115329207 @default.
- W2989888510 cites W2121103946 @default.
- W2989888510 cites W2128482297 @default.
- W2989888510 cites W2130479394 @default.
- W2989888510 cites W2134129243 @default.
- W2989888510 cites W2138045300 @default.
- W2989888510 cites W2143210482 @default.
- W2989888510 cites W2145541286 @default.
- W2989888510 cites W2154053567 @default.
- W2989888510 cites W2170678561 @default.
- W2989888510 cites W2170747616 @default.
- W2989888510 cites W2208578958 @default.
- W2989888510 cites W2254740876 @default.
- W2989888510 cites W2259531529 @default.
- W2989888510 cites W2400814742 @default.
- W2989888510 cites W2404252289 @default.
- W2989888510 cites W2508405377 @default.
- W2989888510 cites W2513786151 @default.
- W2989888510 cites W2519691041 @default.
- W2989888510 cites W2528970029 @default.
- W2989888510 cites W2553132141 @default.
- W2989888510 cites W2587688848 @default.
- W2989888510 cites W2606314633 @default.
- W2989888510 cites W2624963583 @default.
- W2989888510 cites W2717783773 @default.
- W2989888510 cites W2726111596 @default.
- W2989888510 cites W2733568508 @default.
- W2989888510 cites W2737403359 @default.
- W2989888510 cites W2737592062 @default.
- W2989888510 cites W2742750032 @default.
- W2989888510 cites W2747811776 @default.
- W2989888510 cites W2750245257 @default.
- W2989888510 cites W2766300642 @default.
- W2989888510 cites W2777941847 @default.
- W2989888510 cites W2778179010 @default.
- W2989888510 cites W2780936345 @default.
- W2989888510 cites W2782148675 @default.
- W2989888510 cites W2782565892 @default.
- W2989888510 cites W2791600746 @default.
- W2989888510 cites W2792533056 @default.
- W2989888510 cites W2800333284 @default.
- W2989888510 cites W2805110914 @default.
- W2989888510 cites W2805523525 @default.
- W2989888510 cites W2805791355 @default.
- W2989888510 cites W2807896518 @default.
- W2989888510 cites W2891893703 @default.
- W2989888510 cites W2893880892 @default.
- W2989888510 cites W2895146543 @default.
- W2989888510 cites W2896636431 @default.
- W2989888510 cites W2899288360 @default.
- W2989888510 cites W2900694973 @default.
- W2989888510 cites W2900779023 @default.
- W2989888510 cites W2905691307 @default.
- W2989888510 cites W2909409778 @default.
- W2989888510 cites W2914174212 @default.
- W2989888510 cites W2947612926 @default.
- W2989888510 cites W2948271017 @default.
- W2989888510 cites W2948476060 @default.
- W2989888510 cites W2949453554 @default.
- W2989888510 cites W2950473530 @default.
- W2989888510 cites W2951639995 @default.
- W2989888510 cites W2953169496 @default.
- W2989888510 cites W2963579612 @default.
- W2989888510 cites W2963614249 @default.
- W2989888510 cites W2966917770 @default.