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- W2989893563 endingPage "e1008008" @default.
- W2989893563 startingPage "e1008008" @default.
- W2989893563 abstract "The shape and number of mitochondria respond to the metabolic needs during the cell cycle of the eukaryotic cell. In the best-studied model systems of animals and fungi, the cells contain many mitochondria, each carrying its own nucleoid. The organelles, however, mostly exist as a dynamic network, which undergoes constant cycles of division and fusion. These mitochondrial dynamics are driven by intricate protein machineries centered around dynamin-related proteins (DRPs). Here, we review recent advances on the dynamics of mitochondria and mitochondrion-related organelles (MROs) of parasitic protists. In contrast to animals and fungi, many parasitic protists from groups of Apicomplexa or Kinetoplastida carry only a single mitochondrion with a single nucleoid. In these groups, mitochondrial division is strictly coupled to the cell cycle, and the morphology of the organelle responds to the cell differentiation during the parasite life cycle. On the other hand, anaerobic parasitic protists such as Giardia, Entamoeba, and Trichomonas contain multiple MROs that have lost their organellar genomes. We discuss the function of DRPs, the occurrence of mitochondrial fusion, and mitophagy in the parasitic protists from the perspective of eukaryote evolution." @default.
- W2989893563 created "2019-12-05" @default.
- W2989893563 creator A5066189564 @default.
- W2989893563 creator A5087959237 @default.
- W2989893563 date "2019-11-21" @default.
- W2989893563 modified "2023-10-17" @default.
- W2989893563 title "Mitochondrial dynamics in parasitic protists" @default.
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