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- W2989938215 abstract "Abstract Human herpesvirus 6B (HHV-6B) belongs to the β-herpesvirus subfamily of the Herpesviridae . To understand capsid assembly and capsid-tegument interactions, here we report atomic structures of HHV-6B capsid and capsid-associated tegument complex (CATC) obtained by cryoEM and sub-particle reconstruction. Compared to other β-herpesviruses, HHV-6B exhibits high similarity in capsid structure but organizational differences in its CATC (pU11 tetramer). 180 “VΛ”-shaped CATCs are observed in HHV-6B, distinguishing from the 255 “Λ”-shaped dimeric CATCs observed in murine cytomegalovirus and the 310 “Δ”-shaped CATCs in human cytomegalovirus. This trend in CATC quantity correlates with the increasing genomes sizes of these β-herpesviruses. Incompatible distances revealed by the atomic structures rationalize the lack of CATC’s binding to triplexes Ta, Tc, and Tf in HHV-6B. Our results offer insights into HHV-6B capsid assembly and the roles of its tegument proteins, including not only the β-herpesvirus-specific pU11 and pU14, but also those conserved across all subfamilies of Herpesviridae ." @default.
- W2989938215 created "2019-12-05" @default.
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- W2989938215 date "2019-11-25" @default.
- W2989938215 modified "2023-09-25" @default.
- W2989938215 title "Atomic structure of the human herpesvirus 6B capsid and capsid-associated tegument complexes" @default.
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- W2989938215 doi "https://doi.org/10.1038/s41467-019-13064-x" @default.
- W2989938215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6877594" @default.
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