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- W2989948039 endingPage "4372" @default.
- W2989948039 startingPage "4372" @default.
- W2989948039 abstract "Chemical inhibitors are invaluable tools for investigating protein function in reverse genetic approaches. Their application bears many advantages over mutant generation and characterization. Inhibitors can overcome functional redundancy, their application is not limited to species for which tools of molecular genetics are available and they can be applied to specific tissues or developmental stages, making them highly convenient for addressing biological questions. The use of inhibitors has helped to elucidate hormone biosynthesis and signaling pathways and here we review compounds that were developed for the plant hormones brassinosteroids (BRs). BRs are steroids that have strong growth-promoting capacities, are crucial for all stages of plant development and participate in adaptive growth processes and stress response reactions. In the last two decades, impressive progress has been made in BR inhibitor development and application, which has been instrumental for studying BR modes of activity and identifying and characterizing key players. Both, inhibitors that target biosynthesis, such as brassinazole, and inhibitors that target signaling, such as bikinin, exist and in a comprehensive overview we summarize knowledge and methodology that enabled their design and key findings of their use. In addition, the potential of BR inhibitors for commercial application in plant production is discussed." @default.
- W2989948039 created "2019-12-05" @default.
- W2989948039 creator A5026296153 @default.
- W2989948039 creator A5036660533 @default.
- W2989948039 creator A5054810365 @default.
- W2989948039 creator A5077096917 @default.
- W2989948039 date "2019-11-29" @default.
- W2989948039 modified "2023-10-18" @default.
- W2989948039 title "Inhibitors of Brassinosteroid Biosynthesis and Signal Transduction" @default.
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